iiinova — where your digital self keeps evolving

Ian Mellis @ianmellis.bsky.social · 12/05/2026

Excited to share that our lab (mellislab.org) is recruiting postdocs to join us at Columbia University! We welcome graduating PhDs from a variety of disciplines who are interested in antiviral immunity, virus evolution, gene and cell therapies, or quantitative biology in general. Link below!

100

Reposted by Ian Mellis

NSF-Simons NITMB @nitmb.bsky.social · 17/04/2026

Travel applications for our upcoming workshop, ‘Cell State Transitions and Fate (in)decisions,’ are due in one week! Don’t miss your opportunity to join a community formalizing a unified framework for understanding plasticity and cell state-fate relationships www.nitmb.org/cell-state-t...

022

Reposted by Ian Mellis

Ben Kuznets-Speck @biophysben.bsky.social · 02/12/2025

Today we’re excited to share Keeping SCORE, a framework that turns any diffusion model into a thermodynamic inference machine. Using only a model’s score function, we compute exact class likelihoods and uncertainty—and even decompose which features drove the decision. www.biorxiv.org/content/10.1...

2142

Reposted by Ian Mellis

Harris Wang @harriswang.bsky.social · 15/11/2025

📢 Our Dept. of Systems Biology at Columbia University has an open tenure-track Assistant Professor position in the broad area of quantitative biology. Come join our awesome department in NYC! Please circulate. apply.interfolio.com/177622 Suggested deadline: 12/15/2025. @columbiasysbio.bsky.social

03136

Ian Mellis @ianmellis.bsky.social · 16/10/2025

Excited to share a job opportunity to work with me and colleagues at Columbia! If you or someone you know would like to be a Research Technician/Assistant working at the interface of molecular systems biology, virology, immunology, and gene and cell therapies, please reach out! (Links below)

110

Ian Mellis @ianmellis.bsky.social · 19/09/2025

Highly productive and innovative group doing elegant quantitative bio spanning theory, experimental and computational methods, and actual applications. If you're interested in a postdoctoral position studying cancer, development, or single cell biology, reach out to Yogesh!

042

Reposted by Ian Mellis

Adam Ameur @adameur.bsky.social · 10/09/2025

New preprint! With PureTarget we achieved >1000× coverage of targets with ~5kb PacBio reads at QV39. This enabled high-resolution analysis of CRISPR-Cas9 outcomes Key finding: Some CRISPR-mutations may only emerge in the second generation, due to germ cell mosaicism www.biorxiv.org/content/10.1...

biorxiv.org

Accurate characterization of CRISPR-Cas9 genome editing outcomes and mosaicism with near-perfect long reads

Background: Genetic mosaicism is a consequence of CRISPR-Cas9 genome editing that is difficult to study, especially when it involves structural variants occurring at low frequency. A comprehensive ana...

053

Reposted by Ian Mellis

Yogesh Goyal @goyallab.bsky.social · 06/07/2025

Excited to share our latest by my postdoc Ben KS: we use statistical physics & Bayesian inference to model genome-wide perturbation outcomes. Remarkably, perturbation responses are encoded in gene "chatter" even before the perturbation–a fundamental insight with broad implications shorturl.at/2LHbw

47125

Reposted by Ian Mellis

William DeWitt @wsdewitt.github.io · 08/06/2025

I'm stoked to have this long-term and highly collaborative effort out in the wild. We present an experimental evolution system to quantitatively study the rapid evolutionary dynamics of B-cell affinity maturation. These evolutionary mechanisms underpin antibody responses and immune memory formation.

13914

Reposted by Ian Mellis

Bloom lab @jbloomlab.bsky.social · 21/01/2025

In new study, we find dramatic differences in specificities of serum neutralizing antibodies in infants w single infection by a recent SARS-CoV-2 strain versus adults/children imprinted by an early viral strain. www.biorxiv.org/content/10.1...

biorxiv.org

SARS-CoV-2 neutralizing antibody specificities differ dramatically between recently infected infants and immune-imprinted individuals

The immune response to viral infection is shaped by past exposures to related virus strains, a phenomenon known as imprinting. For SARS-CoV-2, much of the population has been imprinted by a viral spik...

1216360

Reposted by Ian Mellis

Tuuli Lappalainen @tuuliel.bsky.social · 06/01/2025

It's an honor to be part of this lecture series to honor Casey's legacy.

093

Ian Mellis @ianmellis.bsky.social · 12/12/2024

Amazing work from @yogogurt.bsky.social lab and Arispe lab on vascular development. Tour de force of quantitative dev bio with thoughtful applications of high-throughput techniques, imaging, stochastic modeling, and more. Congrats to @daniellepi.bsky.social, Jonas, and the team!

020