iiinova — where your digital self keeps evolving

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Genetics Society of America @genetics-gsa.bsky.social · 20h

Applications are open for the Drosophila Trainee Award! Graduate students and postdocs can request up to $1,000 in travel support to attend #Dros27. GSA membership required. Apply by October 29: buff.ly/Ceok9ob

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Shefali @iamshef.bsky.social · 06/10/2026

Ya I get filter coffee every time I stop there - it's so good! I think the Bangalore airport also has something similar.

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Shefali @iamshef.bsky.social · 06/10/2026

Talde Noodle Bar at LaGuardia And I think the Indian airports have such good food pretty much all across - esp the Delhi airport has such good kebabs and filter coffee 👌🏽

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Harmit Singh Malik @harmitmalik.bsky.social · 06/10/2026

Airports, where you're likely to be stuck for long periods, should have a list of great places to eat. If your wait is long, you could even switch terminals for a perfect bite. One of these long delays led me to discover Tortas Frontera at Chicago O'Hare Airport. What are your gems, hidden or not?

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Shefali @iamshef.bsky.social · 06/10/2026

I am seeing both - I know of at least a couple faculty who hired postdocs in the spring for them to start in winter/early next spring. Also earlier helps if there's a fellowship possibility. But there are faculty who also have a shorter timeframe and want someone to start at the earliest.

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Dr. Kat Napaaqtuk❄️ @napaaqtuk.bsky.social · 05/10/2026

PIs: when do you want students to reach out about postdoc position requests? It used to be that students had to reach out a year before graduation. A grad student who is graduating next spring was told by several people to reach out closer to graduation (also that she is a good fit). Is that new?

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Karl Deisseroth @deisseroth.bsky.social · 05/10/2026

Thank you to everyone sharing in this moment! I’m so grateful to all my trainees & collaborators… dlab.stanford.edu/group-members (pic: Peter and I together in 2017) Reading for all those asking: for technical details: dlab.stanford.edu for everyone: deisseroth.org/projections

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Shefali @iamshef.bsky.social · 05/10/2026

Ordering a biryani Monday evening because it's been a long day.

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Shefali @iamshef.bsky.social · 05/10/2026

Is this happening to other south asian (desi) folks as well ? - chalre chalre waaal is literally all over my Instagram feed (I know it's an older song but the new female rendition is pretty good) youtu.be/NVrDyEyQ-Ac?... #desi #folk

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Harmit Singh Malik @harmitmalik.bsky.social · 05/10/2026

Every manuscript submitted to preprint servers or for peer review should include a Pangram score to give an idea of how much of the paper's content was AI-generated. Journals need not draw a 'red line' (they should), but we should have this information before deciding whether we want to review it.

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Shefali @iamshef.bsky.social · 04/10/2026

My barista complimented me and my sweater ☺️🤭 #fall #coffee

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Max Heiman @heiman.bsky.social · 02/10/2026

GPT-5.6 could not correctly solve the C. elegans genetics problem set I wrote! There is still a glimmer of hope for people who think.

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c0nc0rdance @c0nc0rdance.bsky.social · 03/10/2026

Let's talk about the HALLOWEEN GENES (really). 1979: It was a dark & stormy night⛈️& a scientist (Eric Wieschaus) is laboring over a microscope🔬, observing the dead remains of ... a fruitfly🪰. But not just ANY fruitfly. This was a TWISTED & MUTATED fruitfly with a GHOSTLY, transparent appearance.

static.klipy.com

Mad Scientist Working in a Laboratory

Alt: Mad Scientist Working in a Laboratory. A man in a lab coat works on a large cabinet sized device covered in proper dials and levers and blinky lights. We used to be researchers. PROPER researchers.

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Genetics Society of America @genetics-gsa.bsky.social · 01/10/2026

Abstract submission for #Dros27 is now open! 🔗: buff.ly/18h4OHf Prep now: ✅ Browse abstract topics ✅ Prepare title and abstract text ✅ Gather co-author names and institutions ✅ Select one email to use for both abstract submission and registration ✅ Select a credit card to pay the submission fee

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DeBerardinis Lab at UT Southwestern Medical Center @rjdlab.bsky.social · 01/10/2026

Pleased to share a new paper with Ling Cai, demonstrating the use of population genomics to identify heterozygous variants in a cobalamin processing gene as a modulator of circulating vitamin B12 levels.

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Mark Peifer (He, him) @peiferlabunc.bsky.social · 02/10/2026

Lovely work from my UNC Biology colleagues!

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Genetics Society of America @genetics-gsa.bsky.social · 01/10/2026

🪱 Read the latest work from @barrlab.bsky.social in #GENETICS that describes a #Celegans pipeline for mechanistic classification of conserved Autosomal dominant polycystic kidney disease (ADPKD) associated missense variants. 🔗 buff.ly/R2nrikZ

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Alejandro Montenegro @aemonten.bsky.social · 01/10/2026

A new issue of CSH Protocols is out! @cshlpress.bsky.social The cover image highlights the work by Zimina et al., who summarize various approaches for examining meiosis & meiotic recombination in maize, & introduce a set of accompanying protocols to study meiosis in this species🌽 ⬇️Links below

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Shefali @iamshef.bsky.social · 01/10/2026

I am really excited to be presenting my work to this amazing #metabolism community from across the world. I am especially grateful, honored (and a little nervous) to present alongside @rjdlab.bsky.social whose work I have always admired. #devbio #physiology

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Harmit Singh Malik @harmitmalik.bsky.social · 01/10/2026

Hello fly and chromosome people in Paris! I’m giving a seminar on Friday October 2nd, kindly hosted by Marie-Anne Felix at IBENS (salle Favard, IBENS 46 rue d'Ulm 75005 Paris) at noon. Come to hear the latest from the lab (although we’re evolutionary biologists so sometimes things move slowly) 🫠

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Shefali @iamshef.bsky.social · 01/10/2026

As usual....maa sending me pictures of my namesake flowers. People often talk about pujor gondho - the fragrance of durga puja, which includes many things one of them being the shiuli flowers - which are also called shefalika or shefali ☺️ 🤩

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Tessa Montague @tessamontague.bsky.social · 29/09/2026

I'm excited to share our new preprint: Generation of a transgenic cephalopod tinyurl.com/pc86jxz8 Cephalopods (cuttlefish, octopus & squid) are crazy critters that dynamically camouflage to their surroundings by changing the color, pattern, & texture of their skin, which they control w their brain.

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Mark Peifer (He, him) @peiferlabunc.bsky.social · 29/09/2026

For the last 34 years I have been on the faculty of the UNC-Chapel Hill Department of Biology and have never regretted that decision. This year we are hiring TWO new Assistant Professors in the broad area of Molecular, Cell, Developmental Biology 1/n bio.unc.edu

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Shefali @iamshef.bsky.social · 30/09/2026

We got a little bit of #fall 😍🍁🍂💃🏽🎃 #iubloomington

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eric lai @lucksmith.bsky.social · 30/09/2026

the Lai lab is legal: 21 years! fantastic gathering of past and current lab stretching over 2 decades. these folks made mountains of discoveries that will last the ages, and continue to fuel new inquiries. im privileged to work with them @mskcancercenter.bsky.social and see them find their success!🧬

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Dr. Arun Sethuraman @arunsethuraman.bsky.social · 29/09/2026

Among the many things as Chair, I've been working on celebrating our awesome faculty, staff, and students at @sandiegostate.bsky.social Biology in newsletters. Here're volumes 1 and 2, featuring the labs of @doc-brock.bsky.social and Gretchen Goodbody, the Director of our Coastal & Marine Institute!

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A/Prof Sam Stehbens PhD (She/Her) @samstehbens.bsky.social · 29/09/2026

Australia officially celebrates #InternatinalCoffeeDay on October 1st. One of my great loves ☕️

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Shefali @iamshef.bsky.social · 29/09/2026

Me, my plants and my coffee - every morning! Cheers 💗

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Mark Peifer (He, him) @peiferlabunc.bsky.social · 28/09/2026

Thank you @biorxivpreprint.bsky.social for making submissions fast and easy. New work from our lab available soon

Defining redundancy in the stickers and spacers of the cell-cell junction protein Canoe's
intrinsically disordered region
Corbin C. Jensen1*, Renick Wiltshire1*, Sarah E. Clark1, Jeremy Lamb1,
Kevin C. Slep1*, and Mark Peifer1,2*
1 Department of Biology, University of North Carolina at Chapel Hill, CB#3280, Chapel Hill, NC
27599-3280, USA
2 Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel
Hill, NC 27599 USA
# These authors contributed equally and are listed alphabetically

Figure 3. CnoIDRScramble localizes to both AJs and nuclei and has mild deficits in function. A-F, H-L,
M, N. Embryos, genotypes, embryonic stages, and antigens indicated. A, B. en face. C, D. cross sections.
C. Wildtype Cno is restricted to apical AJs, (yellow arrow) and absent from lateral borders (cyan arrow) and
nuclei (magenta arrow). D. CnoIDRScramble is also enriched at apical AJs (yellow arrow) relative to lateral
borders (cyan arrow) but accumulates in nuclei (magenta arrow). E, F. While wildtype Cno is enriched at
TCJs relative to bicellular borders (E, magenta vs cyan arrows), TCJ enrichment of CnoIDRScramble is
reduced. F. TCJ enrichment. H-J. Most cnoIDRScramble mutants complete ventral furrow invagination (H,
arrow) like wildtype (I), and if defects are seen they are mild (J, arrows). K. Wildtype. AJs have very few
gaps. L. cnoIDRScramble has a somewhat elevated number of small gaps. (cyan arrows). M. Gap
frequency. N. Wildtype cells round up for mitosis (arrows) and then resume columnar shapes. O. Some
cnoIDRScramble mutants have delays in cells resuming columnar shapes (arrows).

Abstract
Cell-cell adherens junctions (AJs) and their dynamic cytoskeletal linkage power morphogenesis. AJs are
enormous complexes with hundreds of proteins linked by multivalent interactions. Like other biomolecular
condensates, intrinsically disordered regions (IDRs) in junctional proteins play important roles in AJ assembly
and function, using spacer elements to span distances, and stickers to engage targets. To define molecular
mechanisms, we need to define the functional units within IDRs. Drosophila Canoe, homolog of human Afadin,
is our model. Canoe mediates morphogenesis and has an extensive IDR, with two conserved F-actin-binding
stickers and two poorly conserved spacers. We combined biochemical, genetic and cell biological approaches
to define the function of these IDR elements. While no single element is essential, deleting the full IDR
essentially eliminates Canoe function. By scrambling the amino acid sequence of the spacers, we find that
length and composition are more important than amino acid sequences, though sequences in the C-terminal
spacer affect Canoe localization. Finally, we test redundancy of the F-actin-binding stickers. Deleting both
reduces but does not eliminate viability, and sensitized assays reveal their redundant roles. These data reveal
the robustness of IDRs.

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Anita Devineni @anitadevineni.bsky.social · 29/09/2026

The Emory Biology department is hiring a tenure-track ecologist at any rank. Deadline is Nov 1, link below! As I've said many times before, I couldn't ask for a more supportive department. Our faculty colleagues, dept chair, and admin staff are truly awesome ❤️ apply.interfolio.com/191783

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Shefali @iamshef.bsky.social · 28/09/2026

You know it's the beginning of a bad week when your Monday begins with finding out that the mass spec facility messed up your Friday samples and you won't have flies for an extra experiment. Not that I have to wrap up my thesis anytime soon 😢

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Brian J. Enquist @bjenquist.bsky.social · 28/09/2026

Please pass along: I’m recruiting PhD students to join our Macroecology Lab. We study physical ecology, macroecology, and biodiversity — spanning scaling, trait-based ecology, theory, comparative biology & ecoinformatics. Several avenues for funding. Please reach out if interested 🧪🌐🌾

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Shefali @iamshef.bsky.social · 27/09/2026

My cursive era never ended, I still pretty much write in cursive. And most people around me get surprised by it.

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Shefali @iamshef.bsky.social · 27/09/2026

Do food odors have a distinct category in the brain, how do insects separate food vs non food odor and how does the brain characterise odor from different sources - beautiful work 🎉🥳 #Drosophila #neuroscience #behavior

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Ivy Chan @ivychanchiwai.bsky.social · 25/09/2026

Our paper on odour categorization in the Drosophila mushroom body is now out in Cell Reports! 🎉 We found that αβ and α′β′ Kenyon cells—but not γ KCs—distinguish food-related from non-food odours at the population level. Very happy to see this work published! 🪰🧠 doi.org/10.1016/j.ce...

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epithelial mechanics fan club @epimechfc.bsky.social · 27/09/2026

In his seminal 1952 theoretical paper, Alan Turing proposed that partial differential equations, representing molecules (“morphogens”) that react with one another and diffuse through space, can encode spontaneous periodic pattern formation. doi.org/10.1098/rstb...

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Shefali @iamshef.bsky.social · 26/09/2026

3-2 it is ! Go Alcaraz ! Go Fritz ! Good game 🎾🥳 #LaverCup

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Gina Baucom @gbaucom.bsky.social · 26/09/2026

Early career faculty in Evolution? I would love to chat with you!

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Larry Hamilton @ichiloe.bsky.social · 26/09/2026

Leaves turning in the White Mountains today.

Forested New England mountainside with bright orange and red scattered among other trees still green.

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