Nature Reviews Rheumatology, Published online: 11 December 2025; doi:10.1038/s41584-025-01327-5Monogenic disorders involving key elements of the TNF pathway now encompass a diverse and expanding group of conditions, spanning autoinflammatory, autoimmune, immunodeficiency and neurodegenerative diseases. This Review discusses the genetic causes, clinical features and current therapeutic strategies for these disorders, emphasizing the value of accurate molecular diagnosis and targeted interventions.

Immune-checkpoint agonists are a promising therapeutic approach for autoimmune disease. This Review discusses the immune-checkpoint receptors PD-1, BTLA and TIGIT as well as the preclinical and clinic...

The collective priorities of the rheumatology field represent the lived experience, and therefore diversity of its members. The ‘mould’ of rheumatology, that is, its culture, structures and expectations, was not created for or by women, but women have slowly changed this mould to make space for diverse perspectives.

The 2025 Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries ...

Nature Reviews Rheumatology, Published online: 01 October 2025; doi:10.1038/s41584-025-01302-0Evidence is emerging that glucagon-like peptide-1 (GLP-1) receptor agonists have anti-inflammatory and chondroprotective properties independent of their effects on weight loss. In this Review, the authors discuss the potential effects of GLP-1 receptor agonists on the incidence, disease activity and progression of various forms of arthritis, as well as practical considerations for their use in this context.

Scientific societies, journals, editors and researchers are pushing back against mean-spirited peer reviews.

Nature Reviews Rheumatology, Published online: 15 September 2025; doi:10.1038/s41584-025-01286-xThis article provides a comprehensive overview of the epidemiology of spondyloarthritis — including axial spondyloarthritis, psoriatic arthritis and peripheral spondyloarthritis — worldwide, as well as the epidemiology of genetic factors implicated in these diseases.

This article provides a comprehensive overview of the epidemiology of spondyloarthritis — including axial spondyloarthritis, psoriatic arthritis and peripheral spondyloarthritis — worldwide, as well a...

Osteoarthritis is a complex, multifactorial disorder affecting the entire joint that can cause pain and is a leading cause of disability and premature work loss.

Even in fields in which women are well represented, they are up to 40% more likely than men to leave research within 20 years.

Huji Xu is part of Nature’s 10, a list of people who shaped science in 2024.

PhD Project - EastBio: Long-range consequences of intestinal helminth infection. at University of Edinburgh, listed on FindAPhD.com

This Review provides an update on the evidence for the three main hypotheses of HLA-B27 in the pathogenesis of spondyloarthritis. The authors discuss the current understanding of the effect of HLA-B27...

This Review provides a comprehensive update on dysregulated type I interferon production and signalling in autoinflammatory interferonopathies, monogenic systemic lupus erythematosus and conditio...