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Dave Hughes

@hughesdc-muscle.bsky.social
420 followers 45 following 36 posts

Assistant Professor | Skeletal Muscle, Atrophy, Aging, Protein Quality Control (PQC) | Views my own | 📚💪🏼🇬🇧 scholar.google.com/citations?user=B…

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Reposted by Dave Hughes
Professor Adam P. Sharples @profadamsharples.bsky.social · 25/02/2026
Our new study is now published in Advanced Science We show that skeletal muscle retains a molecular memory of disuse Young muscle shows transcriptional resilience Aged muscle shows exaggerated vulnerability advanced.onlinelibrary.wiley.com/doi/10.1002/...
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Reposted by Dave Hughes
Professor Adam P. Sharples @profadamsharples.bsky.social · 31/10/2025
First post on Blue Sky New pre-print! Does muscle remember disuse muscle wasting? Our new study shows skeletal muscle retains a molecular memory of disuse! Young muscle shows transcriptional resilience to repeated atrophy. Aged muscle shows exaggerated susceptibility. doi.org/10.1101/2025...
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Dave Hughes @hughesdc-muscle.bsky.social · 25/10/2025
One of my former mentors now on BlueSky. Welcome @profadamsharples.bsky.social #MyoBlue 💪🏼
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Dave Hughes @hughesdc-muscle.bsky.social · 18/10/2025
Played a small part in this project, but there some really interesting and cool findings from the Sharples Lab here. Focus on the memory of repeat muscle atrophy in human skeletal muscle 💪
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Reposted by Dave Hughes
Centre for Muscle Research (CMR) @unimelbcmr.bsky.social · 14/10/2025
Checkout the new paper from @hughesdc-muscle.bsky.social & Team, which also involved the CMR's @craigagoodman1.bsky.social Response of UBR-box E3 ubiquitin ligases & protein quality control pathways to perturbations in protein synthesis & skeletal muscle size journals.physiology.org/doi/abs/10.1...
journals.physiology.org
Response of UBR-box E3 ubiquitin ligases and protein quality control pathways to perturbations in protein synthesis and skeletal muscle size | American Journal of Physiology-Cell Physiology | American...
The N-degron pathway contributes to proteolysis by targeting N-terminal residues of destabilized proteins via E3 ligases that contain a UBR-box domain. Emerging evidence suggests the UBR-box family of...
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Reposted by Dave Hughes
Craig A. Goodman @craigagoodman1.bsky.social · 30/08/2025
Congrats to Steffen Raun, Lykke Sylow and Team for their new Redox Biology paper, "Skeletal muscle Rac1 mediates exercise training adaptations towards muscle glycogen resynthesis and protein synthesis", that included the CMR's Prof Paul Gregorevic www.sciencedirect.com/science/arti...
sciencedirect.com
Skeletal muscle Rac1 mediates exercise training adaptations towards muscle glycogen resynthesis and protein synthesis
Long-term exercise training elicits tremendous health benefits; however, the molecular understanding is incomplete and identifying therapeutic targets…
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Dave Hughes @hughesdc-muscle.bsky.social · 29/07/2025
New Preprint alert 🚨 | Future insight into the direction of the lab too #MyoBlue Response of UBR-box E3 ubiquitin ligases and protein quality control pathways to perturbations in protein synthesis and skeletal muscle size www.biorxiv.org/content/10.1...
biorxiv.org
Response of UBR-box E3 ubiquitin ligases and protein quality control pathways to perturbations in protein synthesis and skeletal muscle size
The N-degron pathway contributes to proteolysis by targeting N-terminal residues of destabilized proteins via E3 ligases that contain a UBR-box domain. Emerging evidence suggests the UBR-box family of...
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Dave Hughes @hughesdc-muscle.bsky.social · 11/07/2025
Applying lessons from limb muscle disuse and ageing to better understand ventilator-induced diaphragm dysfunction | #MyoBlue pubmed.ncbi.nlm.nih.gov/40638619/
pubmed.ncbi.nlm.nih.gov
Applying lessons from limb muscle disuse and ageing to better understand ventilator-induced diaphragm dysfunction - PubMed
Mechanical ventilation (MV) is a life-saving intervention applied to critically ill patients. A common consequence of MV is ventilator-induced diaphragm dysfunction (VIDD), which is characterized by s...
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Dave Hughes @hughesdc-muscle.bsky.social · 11/07/2025
Muscle AMP deaminase activity was lower in Neandertals than in modern humans pubmed.ncbi.nlm.nih.gov/40640132/
pubmed.ncbi.nlm.nih.gov
Muscle AMP deaminase activity was lower in Neandertals than in modern humans - PubMed
The enzyme AMPD1 is expressed in skeletal muscle and is involved in ATP production. All available Neandertal genomes carry a lysine-to-isoleucine substitution at position 287 in AMPD1. This variant, w...
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Dave Hughes @hughesdc-muscle.bsky.social · 15/06/2025
Sex differences in resting skeletal muscle and the acute and long-term response to endurance exercise in individuals with overweight and obesity pubmed.ncbi.nlm.nih.gov/40516819/
pubmed.ncbi.nlm.nih.gov
Sex differences in resting skeletal muscle and the acute and long-term response to endurance exercise in individuals with overweight and obesity - PubMed
Endurance exercise reduces the risk of metabolic diseases by improving skeletal muscle metabolism, particularly in individuals with overweight and obesity. As biological sex impacts glucose and fatty ...
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Dave Hughes @hughesdc-muscle.bsky.social · 14/06/2025
Reduction in Acetylation of Superoxide Dismutase 2 in Skeletal Muscle Improves Exercise Capacity in Mice With Heart Failure | #MyoBlue pubmed.ncbi.nlm.nih.gov/40511632/
pubmed.ncbi.nlm.nih.gov
Reduction in Acetylation of Superoxide Dismutase 2 in Skeletal Muscle Improves Exercise Capacity in Mice With Heart Failure - PubMed
The SIRT3 activator Honokiol improved exercise capacity in MI model mice with HF, by improving mitochondrial function in skeletal muscle through the reduction of SOD2 acetylation. SIRT3 activation may...
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Dave Hughes @hughesdc-muscle.bsky.social · 14/06/2025
Resistance exercise and skeletal muscle: protein synthesis, degradation, and controversies | #MyoBlue pubmed.ncbi.nlm.nih.gov/40512179/
pubmed.ncbi.nlm.nih.gov
Resistance exercise and skeletal muscle: protein synthesis, degradation, and controversies - PubMed
Maintaining and enhancing skeletal muscle mass and strength are essential for optimizing metabolic function and preventing chronic diseases. Resistance exercise plays a pivotal role in this process by...
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Reposted by Dave Hughes
Martino V. Franchi @mvfranchi.bsky.social · 01/06/2025
A new Translational Perspective published in @jphysiol.bsky.social by Mark Viggars and @kaesser.bsky.social related to our previous manuscript on disuse and retraining physoc.onlinelibrary.wiley.com/doi/10.1113/...
physoc.onlinelibrary.wiley.com
Reprogramming metabolic gene expression during active recovery following disuse
Click on the article title to read more.
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Dave Hughes @hughesdc-muscle.bsky.social · 12/05/2025
The contribution of age and sex hormones to female neuromuscular function across the adult lifespan | #MyoBlue pubmed.ncbi.nlm.nih.gov/40349308/
pubmed.ncbi.nlm.nih.gov
The contribution of age and sex hormones to female neuromuscular function across the adult lifespan - PubMed
Neuromuscular ageing is characterized by neural and/or skeletal muscle degeneration that decreases maximal force and power. Female neuromuscular ageing occurs earlier in life compared to males, potent...
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Reposted by Dave Hughes
Craig A. Goodman @craigagoodman1.bsky.social · 27/04/2025
3D Mitochondrial Structure in Aging Human Skeletal Muscle: Insights Into MFN-2-Mediated Changes onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
3D Mitochondrial Structure in Aging Human Skeletal Muscle: Insights Into MFN‐2‐Mediated Changes
Changes in mitochondrial structure and dynamics during aging provide a mechanism for the development of age-related sarcopenia, a condition characterized by muscle mass loss. Through the creation of ....
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Reposted by Dave Hughes
Craig A. Goodman @craigagoodman1.bsky.social · 28/04/2025
Muscle mTOR controls iron homeostasis and ferritinophagy via NRF2, HIFs and AKT/PKB signaling pathways link.springer.com/article/10.1...
link.springer.com
Muscle mTOR controls iron homeostasis and ferritinophagy via NRF2, HIFs and AKT/PKB signaling pathways - Cellular and Molecular Life Sciences
Balanced mTOR activity and iron levels are crucial for muscle integrity, with evidence suggesting mTOR regulates cellular iron homeostasis. In this study, we investigated iron metabolism in muscle-spe...
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Reposted by Dave Hughes
Katsu Funai @katsufunai.bsky.social · 29/04/2025
For those just returning from the APS Summit, I encourage you to submit your work to FUNCTION, an APS journal that covers a wide range of topics relevant to physiology.
academic.oup.com
Function | Oxford Academic
Function is an online-only, open access journal new in 2020. Function will publish research covering advances in basic, translational, and clinical science that extend the physiological or pathophysio...
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Dave Hughes @hughesdc-muscle.bsky.social · 01/04/2025
Muscle wasting in cancer cachexia: Mechanisms and the role of exercise | #MyoBlue pubmed.ncbi.nlm.nih.gov/40159295/
pubmed.ncbi.nlm.nih.gov
Muscle wasting in cancer cachexia: Mechanisms and the role of exercise - PubMed
Cancer cachexia (CC) is a multifactorial disease marked by a severe and progressive loss of lean muscle mass and characterized further by inflammation and a negative energy/protein balance, ultimately...
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Reposted by Dave Hughes
Craig A. Goodman @craigagoodman1.bsky.social · 27/03/2025
Mechanotransduction and Skeletal Muscle Atrophy: The Interplay Between Focal Adhesions and Oxidative Stress www.mdpi.com/1422-0067/26...
mdpi.com
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Reposted by Dave Hughes
Russ at UF @rthepple.bsky.social · 21/03/2025
Attention mitochondriacs! Mitochondrial supercomplexes by cryo-electron tomography. How can you not be blown away by how beautiful this is? Fascinating that ATP synthase is largely organized as dimers since this is one of the putative configurations of mPT pore. www.science.org/doi/10.1126/...
science.org
In-cell architecture of the mitochondrial respiratory chain
Mitochondria regenerate adenosine triphosphate (ATP) through oxidative phosphorylation. This process is carried out by five membrane-bound complexes collectively known as the respiratory chain, workin...
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Dave Hughes @hughesdc-muscle.bsky.social · 20/03/2025
The Role and Regulation of Intramuscular Sex Hormones in Skeletal Muscle: A Systematic Review | #MyoBlue pubmed.ncbi.nlm.nih.gov/40101148/
pubmed.ncbi.nlm.nih.gov
The Role and Regulation of Intramuscular Sex Hormones in Skeletal Muscle: A Systematic Review - PubMed
Current evidence suggests that ageing and exercise differentially modulate intramuscular sex hormone concentrations, and their association with muscle mass and function, between males and females, and...
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Dave Hughes @hughesdc-muscle.bsky.social · 20/03/2025
Increased contact between lipid droplets and mitochondria in skeletal muscles of male elite endurance athletes | #MyoBlue pubmed.ncbi.nlm.nih.gov/40105858/
pubmed.ncbi.nlm.nih.gov
Increased contact between lipid droplets and mitochondria in skeletal muscles of male elite endurance athletes - PubMed
Endurance athletes exhibit higher skeletal muscle mitochondrial and lipid droplet (LD) content compared to recreationally active individuals, along with greater whole-body oxygen uptake and maximal fa...
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Dave Hughes @hughesdc-muscle.bsky.social · 15/03/2025
Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance pubmed.ncbi.nlm.nih.gov/40044687/ | #MyoBlue
pubmed.ncbi.nlm.nih.gov
Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance - PubMed
The neuromuscular junction (NMJ) is the synapse formed between motor neurons and skeletal muscle fibers. Its stability relies on the continued expression of genes in a subset of myonuclei, called NMJ ...
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Dave Hughes @hughesdc-muscle.bsky.social · 15/03/2025
Mitochondrial fatty acid oxidation regulates adult muscle stem cell function through modulating metabolic flux and protein acetylation pubmed.ncbi.nlm.nih.gov/40065099/ | #MyoBlue
pubmed.ncbi.nlm.nih.gov
Mitochondrial fatty acid oxidation regulates adult muscle stem cell function through modulating metabolic flux and protein acetylation - PubMed
During homeostasis and regeneration, satellite cells, the resident stem cells of skeletal muscle, have distinct metabolic requirements for fate transitions between quiescence, proliferation and differ...
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Reposted by Dave Hughes
Matthew Alexander, PhD @mattmuscleguy.bsky.social · 06/03/2025
Congrats to #RueggLab and colleagues on their new #NatComms paper: Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance. #Myoblue tinyurl.com/yeynb3t2
tinyurl.com
Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance - Nature Communications
Here they use single nuclei RNA-seq to identify transcripts in skeletal muscle that maintain the neuromuscular junction, both under normal and denervated conditions, which allows them to characterize ...
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Reposted by Dave Hughes
Craig A. Goodman @craigagoodman1.bsky.social · 04/03/2025
Deubiquitinating Enzymes Regulate Skeletal Muscle Mitochondrial Quality Control and Insulin Sensitivity in Patients With Type 2 Diabetes onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Deubiquitinating Enzymes Regulate Skeletal Muscle Mitochondrial Quality Control and Insulin Sensitivity in Patients With Type 2 Diabetes
Background Activation of mitochondrial fission and quality control occur early in the onset of insulin resistance in human skeletal muscle. We hypothesized that differences in mitochondrial dynamics...
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Dave Hughes @hughesdc-muscle.bsky.social · 03/02/2025
🚨🚨| For any American Physiological Society members, voting is open for President-Elect with the vote closing on Feb 28th. I encourage all to check out candidates but especially Sue Bodine, PhD who is on the ballot this year! #VoteBodine #MyoBlue
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Dave Hughes @hughesdc-muscle.bsky.social · 30/01/2025
The ubiquitin-conjugating enzyme UBE2D maintains a youthful proteome and ensures protein quality control during aging by sustaining proteasome activity | #MyoBlue pubmed.ncbi.nlm.nih.gov/39879147/
pubmed.ncbi.nlm.nih.gov
The ubiquitin-conjugating enzyme UBE2D maintains a youthful proteome and ensures protein quality control during aging by sustaining proteasome activity - PubMed
Ubiquitin-conjugating enzymes (E2s) are key for protein turnover and quality control via ubiquitination. Some E2s also physically interact with the proteasome, but it remains undetermined which E2s ma...
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Dave Hughes @hughesdc-muscle.bsky.social · 29/01/2025
Limiting cap-dependent translation increases 20S proteasomal degradation and protects the proteomic integrity in autophagy-deficient skeletal muscle pubmed.ncbi.nlm.nih.gov/39878121/ | #MyoBlue
pubmed.ncbi.nlm.nih.gov
Limiting cap-dependent translation increases 20S proteasomal degradation and protects the proteomic integrity in autophagy-deficient skeletal muscle - PubMed
Postmitotic skeletal muscle critically depends on tightly regulated protein degradation to maintain proteomic stability. Impaired macroautophagy/autophagy-lysosomal or ubiquitin-proteasomal protein de...
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Dave Hughes @hughesdc-muscle.bsky.social · 29/01/2025
Deubiquitinating enzyme USP2 alleviates muscle atrophy by stabilizing PPARγ pubmed.ncbi.nlm.nih.gov/39874418/ | #MyoBlue
pubmed.ncbi.nlm.nih.gov
Deubiquitinating enzyme USP2 alleviates muscle atrophy by stabilizing PPARγ - PubMed
Insulin resistance, a hallmark of type 2 diabetes, accelerates muscle breakdown and impairs energy metabolism. However, the role of Ubiquitin Specific Peptidase 2 (USP2), a key regulator of insulin re...
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Dave Hughes @hughesdc-muscle.bsky.social · 28/01/2025
Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans | #MyoBlue pubmed.ncbi.nlm.nih.gov/39869194/
pubmed.ncbi.nlm.nih.gov
Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans - PubMed
Adult males and females have markedly different body composition, energy expenditure, and have different degrees of risk for metabolic diseases. A major aspect of metabolic regulation involves the app...
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Reposted by Dave Hughes
Craig A. Goodman @craigagoodman1.bsky.social · 23/01/2025
The deubiquitinase USP5 prevents accumulation of protein aggregates in cardiomyocytes www.science.org/doi/10.1126/...
science.org
The deubiquitinase USP5 prevents accumulation of protein aggregates in cardiomyocytes
The deubiquitinase USP5 prevents accumulation of polyubiquitin chains and protein aggregates in cardiomyocytes.
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Reposted by Dave Hughes
Russ at UF @rthepple.bsky.social · 22/01/2025
Want to come work with us to understand the role of mitochondrial permeability transition in skeletal muscle? Postdoc position available at UF on the BREATHE T32 (US citizens and permanent residents eligible). breathe.phhp.ufl.edu/training/bre...
breathe.phhp.ufl.edu
BREATHE Application » Breathing Research and Therapeutics Center » College of Public Health and Health Professions » University of Florida
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Reposted by Dave Hughes
Zoe McElligott @nanopharmnc.bsky.social · 22/01/2025
I just reached out to my senators about the NIH situation. If you need to find out how much impact NIH has in your state in terms of dollars in and their economic impact here's a link: www.unitedformedicalresearch.org/nih-in-your-...
unitedformedicalresearch.org
NIH In Your State - United For Medical Research
Select a state on the map to see the impact of NIH funding across America.
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Reposted by Dave Hughes
Abigail Mackey @abigailmackey1.bsky.social · 06/01/2025
Starting off 2025 on a high with this review @jphysiol.bsky.social doi.org/10.1113/JP28... Casper Soendenbroe and I joined forces with 🤩neuroscientist Carl Johan Boraxbekk @ismcopenhagen.bsky.social Enhancing 💪 and 🧠 resilience: The role of prehabilitative exercise in mitigating disuse effects
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Dave Hughes @hughesdc-muscle.bsky.social · 06/01/2025
The role of skeletal muscle respiratory capacity in exercise performance | #MyoBlue Review pubmed.ncbi.nlm.nih.gov/39755219/
pubmed.ncbi.nlm.nih.gov
The role of skeletal muscle respiratory capacity in exercise performance - PubMed
The connection between the respiratory capacity of skeletal muscle mitochondria and athletic performance is widely acknowledged in contemporary research. Building on a solid foundation of prior studie...
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Dave Hughes @hughesdc-muscle.bsky.social · 31/12/2024
In vivo imaging of glycogen in human muscle pubmed.ncbi.nlm.nih.gov/39737980/ | #MyoBlue
pubmed.ncbi.nlm.nih.gov
In vivo imaging of glycogen in human muscle - PubMed
Probing regional glycogen metabolism in humans non-invasively has been challenging due to a lack of sensitive approaches. Here we studied human muscle glycogen dynamics post-exercise with a spatial re...
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Reposted by Dave Hughes
Ken Humphries @ken-humphries.bsky.social · 29/12/2024
I'm excited about this- in this study we identified a new inhibitor of PFKFB kinase activities and we're hopeful for future applications. www.biorxiv.org/content/10.1...
biorxiv.org
Mechanistic studies of PFKFB2 reveals a novel inhibitor of its kinase activity
The 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase (PFKFB) family of proteins are bifunctional enzymes that are of clinical relevance because of their roles in regulating glycolysis in insulin se...
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Reposted by Dave Hughes
Frank Schnorrer @frankschnorrer.bsky.social · 19/12/2024
Muscles growth by sarcomere divisions - how your muscles add new sarcomeres during developmental growth: they divide! Cool collaboration @friedrich-group.bsky.social @raunser-lab.bsky.social @Dirk Görlich @univ-amu.fr @cnrs.bsky.social sciencecast.org/casts/aspy9l... www.biorxiv.org/content/10.1...
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Dave Hughes @hughesdc-muscle.bsky.social · 22/12/2024
Chaperone Proteins: The Rising Players in Muscle Atrophy | #MyoBlue pubmed.ncbi.nlm.nih.gov/39707668/
pubmed.ncbi.nlm.nih.gov
Chaperone Proteins: The Rising Players in Muscle Atrophy - PubMed
Despite significant progress in understanding the molecular aetiology of muscle atrophy, there is still a great need for new targets and drugs capable of counteracting muscle wasting. The role of an i...
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Reposted by Dave Hughes
Andy Judge @andyjudge24.bsky.social · 14/12/2024
Abstract deadline to be considered for an oral presentation at the 2025 Advances in Skeletal Muscle Biology Conference is tomorrow (Dec 15) ⏱️✍️ @myoblue.bsky.social
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Craig A. Goodman @craigagoodman1.bsky.social · 07/12/2024
Purification of mitochondria from skeletal muscle tissue for transcriptomic analyses reveals localization of nuclear-encoded noncoding RNAs faseb.onlinelibrary.wiley.com/doi/10.1096/...
faseb.onlinelibrary.wiley.com
Purification of mitochondria from skeletal muscle tissue for transcriptomic analyses reveals localization of nuclear‐encoded noncoding RNAs
The present study establishes a process for purification of mitochondria from skeletal muscle tissue that is suitable for transcriptomic analysis. Using this approach, small RNA sequencing of mitocho...
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Dave Hughes @hughesdc-muscle.bsky.social · 06/12/2024
Estradiol deficiency as a consequence of aging contributes to the depletion of the satellite cell pool in female mice | #MyoBlue pubmed.ncbi.nlm.nih.gov/39641290/
pubmed.ncbi.nlm.nih.gov
Estradiol deficiency as a consequence of aging contributes to the depletion of the satellite cell pool in female mice - PubMed
The effects of aging on the satellite cell pool have primarily been studied in male mice, where the role of cell-intrinsic versus environmental changes on satellite cell function remains contentious. ...
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Reposted by Dave Hughes
Craig A. Goodman @craigagoodman1.bsky.social · 06/12/2024
Diversity in Chemotherapy-Induced Cachexia journals.physiology.org/doi/abs/10.1...
journals.physiology.org
Diversity in Chemotherapy-Induced Cachexia | American Journal of Physiology-Cell Physiology
Preclinical and clinical studies suggest that chronic administration of cytotoxic drugs (e.g., chemotherapy) may contribute to the occurrence of skeletal muscle wasting and weakness/fatigue (i.e., cac...
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Reposted by Dave Hughes
Aging and Metabolism @am-omrf.bsky.social · 23/11/2024
Check it out ⤵️ Several of our scientists and outstanding trainees are on Bluesky. go.bsky.app/5oUbpNy
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Centre for Muscle Research (CMR) @unimelbcmr.bsky.social · 04/12/2024
Congratulations to the CMR's newly graduated Dr Jin Dylan Chung & Prof Gordon Lynch & MCRI's Prof Enzo Porrello for their new review on "Muscle regeneration and muscle stem cells in metabolic disease" www.sciencedirect.com/science/arti...
sciencedirect.com
Muscle regeneration and muscle stem cells in metabolic disease
Skeletal muscle has a high regenerative capacity due to its resident adult muscle stem cells (MuSCs), which can repair damaged tissue by forming myofi…
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Reposted by Dave Hughes
Karyn @kaesser.bsky.social · 29/11/2024
I am excited to share a new review led by Spencer Procopio, a PhD student in the lab. Clockwork conditioning: Aligning the skeletal muscle clock with time of exercise focusing on cardiometabolic health. www.sciencedirect.com/science/arti...
sciencedirect.com
Clockwork conditioning: Aligning the skeletal muscle clock with time-of-day exercise for cardiometabolic health
Circadian rhythms have evolved to synchronize gene expression, physiology, and behavior with time-of-day changes in the external environment. In every…
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Reposted by Dave Hughes
Craig A. Goodman @craigagoodman1.bsky.social · 28/11/2024
Nicotinic acid improves mitochondrial function and associated transcriptional pathways in older inactive males www.degruyter.com/document/doi...
degruyter.com
Nicotinic acid improves mitochondrial function and associated transcriptional pathways in older inactive males
Objectives To examine the effect of the NAD + precursor, nicotinic acid (NA), for improving skeletal muscle status in sedentary older people. Methods In a double-blind, randomised, placebo-controlled ...
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Dave Hughes @hughesdc-muscle.bsky.social · 26/11/2024
After a great visit last week to Virginia, next week is a visit to Florida. Enjoying these opportunities to share our latest work on E3 ligases, metabolism and protein synthesis. 💪🏼
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Craig A. Goodman @craigagoodman1.bsky.social · 23/11/2024
Transcriptomic analysis of skeletal muscle regeneration across mouse lifespan identifies altered stem cell states www.nature.com/articles/s43...
nature.com
Transcriptomic analysis of skeletal muscle regeneration across mouse lifespan identifies altered stem cell states - Nature Aging
Skeletal muscle regeneration declines during aging but the underlying processes are incompletely understood. Here the authors generated single-cell and spatial transcriptomics data from uninjured and ...
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