Cardiac aging is associated with metabolic changes, including an increased reliance on glycolysis, and an increased susceptibility to cardiovascular diseases. This study explores the relationship betw...

Ovarian aging is characterized by declines in follicular reserve and the emergence of mitochondrial dysfunction, reactive oxygen species production, inflammation, and fibrosis, which eventually result...

The 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase (PFKFB) family of proteins are bifunctional enzymes that are of clinical relevance because of their roles in regulating glycolysis in insulin se...

Matheny-Rabun and colleagues discover that O-GlcNAc modification of rate-limiting enzymes within the N-glycosylation pathway impacts their function, drawing a connection between two spatially separate...

Findings may explain mood changes that precede disease