Zebrafish can regenerate neurons after spinal cord injury, but the mechanisms influencing this ability remain unknown. This study shows that Sema4ab, a protein expressed in lesion-reactive microglia, attenuates regenerative neurogenesis by directly regulating neural progenitors and altering cytokine signaling in the niche.

Communication between distant brain regions is mediated by plastic networks of gap junction-coupled astrocytes.

Ghenissa et al. provide evidence that basolateral amygdala astrocytes reliably encode anxiety states. Using simultaneous in vivo calcium recordings across an array of behavioral tasks, combined with g...

The excitatory neuron diversity and specialized connectivity of complex, multilayered mammalian neocortex are driven by mammalian-specific cis-regulatory elements bound by ZBTB18, deletion of which di...

Prior to the formation of the present-day North Sea during the mid-Holocene, North-Western Europe was connected through the Doggerland landmass. Wh...

Lemmik et al. report that genetic deletion of C3ar1 in mice does not result in behavioural changes nor brain changes as measured by structural and function

Denisovans, an extinct sister group of Neandertals who lived in Eastern Eurasia during the Middle and Late Pleistocene, are known only from a handful of skeletal remains and limited genetic data, incl...

Following the decision that eLife will not receive an Impact Factor in 2025, we share an update on how our model is doing since we were first placed “on hold” by Web of Science, and what we’re up to…