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HittingerLab

@hittingerlab.bsky.social

524 followers 655 following 69 posts

Yeast evolutionary genomics with applications in brewing and bioenergy at the University of Wisconsin-Madison. Moderated by Hittinger Lab members. Opinions do not necessarily belong to anyone. Lab website: hittinger.genetics.wisc.edu.

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HittingerLab @hittingerlab.bsky.social · 14/07/2026

You can also download this highlight on the GLBRC website linked above:

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HittingerLab @hittingerlab.bsky.social · 08/06/2026

Two members of the Hittinger Lab received awards during the annual All-Wisconsin Energy Institute (WEI) meeting. Our lab manager, Amanda Hulfachor, won the Excellence Award and Sam Davison, a CMB graduate student, won the award for Community Impact. Congrats to both - we are very proud!⭐⭐⭐

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HittingerLab @hittingerlab.bsky.social · 27/01/2026

We're excited to announce that Chris will be attending the Yeast Genetics Meeting organized by the Genetics Society of America (GSA) @genetics-gsa.bsky.social in CA on June 13-17! #Yeast26 If you are interested in attending or presenting, follow this link to register! genetics-gsa.org/yeast-2026/

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HittingerLab @hittingerlab.bsky.social · 09/12/2025

Congratulations to our wonderful PI, Chris Todd Hittinger, on receiving the Vilas Mid-Career Investigator Award from the UW–Madison Laboratory of Genetics! This recognition highlights his continued excellence in research, teaching, training, and mentorship. 🎉 genetics.wisc.edu/2025/12/09/d...

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HittingerLab @hittingerlab.bsky.social · 08/12/2025

We were featured in the Yeast Newsletter, published in June and December every year with Western University, serving as an informal communication method for those interested in all things yeast-biology. Checkout pages 18-23! www.uwo.ca/biology/Yeas...

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HittingerLab @hittingerlab.bsky.social · 07/10/2025

ECAR variation is associated with glycolyitc genes across the yeast subphylum (Figure 1 in this work)

https://www.biorxiv.org/content/10.1101/2025.10.02.679963v2

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HittingerLab @hittingerlab.bsky.social · 02/07/2025

Congrats to @emuthemycologist.bsky.social for presenting her first talk at #MSAfungi25!

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HittingerLab @hittingerlab.bsky.social · 15/05/2025

Congratulations to @linder-surprise.bsky.social for winning an award for mentoring undergraduates from the office of the Provost! 🎉 @glbioenergy.bsky.social @uwenergy.bsky.social

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HittingerLab @hittingerlab.bsky.social · 06/05/2025

Congratulations to Katarina Aranguiz for being recognized with an award for best poster at the UW-Madison Fungal Supergroup Undergraduate Symposium! @glbioenergy.bsky.social @uwbiochem.bsky.social

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HittingerLab @hittingerlab.bsky.social · 30/04/2025

Congratulations to Lizza Korolev for being awarded the Hilldale Fellowship to support her undergraduate research! @glbioenergy.bsky.social @uwenergy.bsky.social @tksato.bsky.social

Lizza holds up a certificate for her fellowship

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HittingerLab @hittingerlab.bsky.social · 21/01/2025

Importantly, this also decreases the variation in fermentation from different harvest years of switchgrass:

A graph showing that increasing the pH from 5 to 5.8 increases ethanol yields from switchgrass hydrolysate.

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HittingerLab @hittingerlab.bsky.social · 12/12/2024

In case you happen to be in Tokyo, Masako Takashima organized on "Yeasts and fermentation: progress brought by genomic data" tomorrow afternoon, 13th December 2024: nodaiweb.university.jp/nric/yeast/i...

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HittingerLab @hittingerlab.bsky.social · 02/12/2024

We also zoomed out to look at the (very large) Major Facilitator Superfamily across diverse yeasts and found that these specialized alpha-glucoside transporters likely evolved from a generalist ancestral transporter. See the full paper for more!

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HittingerLab @hittingerlab.bsky.social · 02/12/2024

Turns out that multiple simultaneous mutations are required for this - explaining why our evolved isolate had a chimeric transporter.

Fig. 2.High-order intramolecular interactions are required to evolve a novel function in chimeric α-glucoside transporters. Points and bars show mean ± standard error of the mean of normalized growth on maltotriose (AUC) of strains expressing chimeric transporters or wild-type MalT4 (top row). Filled circles denote growth significantly greater than the negative control (P < 0.01, Mann–Whitney U test with Benjamini–Hochberg correction). The architecture of each tested transporter is depicted as a cartoon on the y axis, where rounded rectangles represent each of the 12 TMHs and circles represent the ICH domain that links the N- and C-terminal six-helix bundles; regions are colored by parental protein identity. In almost every case, the N- and C-terminal intracellular regions have the same parental protein identity as the neighboring TMH and are omitted for clarity; the two exceptions are depicted. Inverted arrows and brackets indicate the location and identity of protein regions underlying the largest detected intramolecular interaction.

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