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Rebecca Hendrickson MD, PhD

@hendricksonmd.bsky.social
316 followers 605 following 33 posts

Psychiatry/Neuroscience: what changes after trauma, why, and how do we thrive? Emphasis on catecholamines, sleep, social cognition, belongingness as necessary for felt security. Opinions my own.

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Rebecca Hendrickson MD, PhD @hendricksonmd.bsky.social · 02/02/2026
But, this first step towards just changing the way we think and talk about these types of experiences and where they come from, is by itself one I believe to be really important.
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Rebecca Hendrickson MD, PhD @hendricksonmd.bsky.social · 02/02/2026
Currently, we're trying to work out individualized tests of some of the specific mechanisms that may be causing both the physical and mental/cognitive symptoms - and that we might be able to treat directly.
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Rebecca Hendrickson MD, PhD @hendricksonmd.bsky.social · 02/02/2026
That people with a higher burden of past trauma exposure report more persistent autonomic symptoms after COVID-19 or other viral infections, even adjusting for symptoms of PTSD or similar symptoms prior to COVID.
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Rebecca Hendrickson MD, PhD @hendricksonmd.bsky.social · 02/02/2026
And while these changes may interact and reinforce each other, they can both be real, without one necessarily being the "real" or primary effect. This paper tests a relationship we've been seeing in our clinical work for years but that hasn't been well studied or recognized:
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Rebecca Hendrickson MD, PhD @hendricksonmd.bsky.social · 02/02/2026
Instead, we need to be able to consider how both psychological stress and trauma and physiologic stressors (e.g. COVID infection, TBI, etc) can both turn on changes in our brain and body's stress-threat response systems that can affect both physical and mental health.
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Rebecca Hendrickson MD, PhD @hendricksonmd.bsky.social · 02/02/2026
But, that's not nec'ly how it works. Treating PTSD, anxiety etc can help substantially with physical symptoms & I will advocate for effective MH treatment all day long. But it doesn't mean that your physiology is now the same as if it hadn't happened - & if it's not, you're just doing it wrong.
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Rebecca Hendrickson MD, PhD @hendricksonmd.bsky.social · 02/02/2026
eg, so many people I see with PTSD have sig physical symptoms - & they have a list of diagnoses (hypertension, IBS, heart palpitations or POTS, etc), or there's an assumption that if they treat their mental health diagnoses and "manage their stress better" then their physical symptoms will be gone.
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Rebecca Hendrickson MD, PhD @hendricksonmd.bsky.social · 02/02/2026
But even when our medical system recognizes that physical and mental/cognitive symptoms are connected, it's assumed that either the physical symptoms are the "real" and primary experience and the psychiatric symptoms are "secondary", or visa versa.
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Rebecca Hendrickson MD, PhD @hendricksonmd.bsky.social · 02/02/2026
It's obvious to most people that you can experience physical symptoms after a stressful event or a trauma - and that physical illness can cause anxiety, insomnia, cognitive changes, etc.
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Rebecca Hendrickson MD, PhD @hendricksonmd.bsky.social · 02/02/2026
tl;dr: Our medical system constantly wants to silo physical and mental health, but they are fundamentally intertwined more than we know how to talk about - and things that cause both physical stress and psychological trauma can interact with each other. journals.sagepub.com/doi/10.1177/...
journals.sagepub.com
Impact of Prior History of Traumatic Stress on Autonomic and Multi-System Symptoms Following COVID-19 Infection - Rebecca C. Hendrickson, Christine S. Cheah, Marlene L. Tai, Kathleen F. Pagulayan, Kat...
Background Persistent symptoms of autonomic dysregulation are common after COVID-19 infection and may result from alterations in central and/or peripheral auton...
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Rebecca Hendrickson MD, PhD @hendricksonmd.bsky.social · 02/02/2026
I was on NPR last week talking about a new publication that is really important to me - part of our larger effort to change the way we think and talk about both mental and physical health, and how they relate to each other, after stress and trauma. www.knkx.org/2026-01-28/u...
knkx.org
UW study shows possible connection between trauma and long COVID
Some people with long COVID may experience certain symptoms — sudden blood pressure spikes or nausea, for instance — due to stress or trauma.
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UW Infectious Disease Fellowship Program @uwidfellowship.bsky.social · 22/11/2025
#IDSky First person with H5N5 has died :(
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John Scott-Railton @jsrailton.bsky.social · 02/09/2025
10/ After 14 years of working on this topic, I tell you this with confidence: Highly invasive mercenary spyware is a power abuse machine. It's incompatible with Americans constitutional rights and freedoms. And our legal system and civil society is not prepared for the next chapter.
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Carl T. Bergstrom @carlbergstrom.com · 19/04/2025
1. The DOJ has sent threatening letters to several medical journals, focused around whether these journals are spreading misinformation that harms the American people and suppressing alternative viewpoints. I study how the norms and institutions of science facilitate discovery and self-correction.
nytimes.com
Trump-Allied Prosecutor Sends Letters to Medical Journals Alleging Bias (Gift Article)
An interim U.S. attorney is demanding information about the selection of research articles and the role of N.I.H. Experts worry this will have a chilling effect on publications.
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Harold D. Foster @mg0blue1976.bsky.social · 06/04/2025
We opted to join Bainbridge Island’s rally, which had well over 1K+ protestors. One of the speakers we heard was a Japanese American internee who, in 1942, was removed from Bainbridge Island to an internment camp with her family. Her closing words: “Never again is now.”
My post flag (9’x17’) flying upside down as a signal of distress at the edge of the rally at Bainbridge Island’s waterfront park on Eagle Harbor.
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Dan Semenza @daniel-semenza.bsky.social · 25/03/2025
Defensive gun use is rare but gun violence exposure is far too common. Check out this interview re: our new study in @jama.com Open from @mikeanestis.bsky.social. Watch the full interview for important thoughts on very real threats to our work @ the GVRC. www.njspotlightnews.org/video/rutger...
njspotlightnews.org
Rutgers study debunks argument that guns make people safer | Video | NJ Spotlight News
Interview: Mike Anestis, executive director of New Jersey Gun Violence Research Center
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Katharine Hayhoe @katharinehayhoe.com · 15/03/2025
I’m am adaptation scientist and here’s what I had to say about this—many years ago already.
theguardian.com
We cannot adapt our way out of climate crisis, warns leading scientist
Katharine Hayhoe says the world is heading for dangers people have not seen in 10,000 years of civilisation
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Dave Levitan @davelevitan.bsky.social · 08/03/2025
Mandatory high school civics class that isn’t just like “how a bill becomes law” or whatever but also “how NOAA powers your phone’s weather app” and “NIH helped make your asthma inhaler”
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Senator Patty Murray @murray.senate.gov · 05/03/2025
Trump is LYING about Social Security right now. Elon Musk called Social Security a "Ponzi scheme." They are cutting staff drastically at Social Security to make it harder for seniors to get their benefits. These corrupt billionaires need to keep their HANDS OFF Social Security!
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Katharine Hayhoe @katharinehayhoe.com · 30/01/2025
On climate, did you know that only 11% of people in the US (and even smaller percentages in Canada, the UK, Australia and beyond) are dismissive? Yet because their voices are so loud and persistent, people often think they’re 50%. This is why I advocate so strongly for using YOUR voice!
Six colored circles representing the proportion of people in the US who are alarmed, concerned, cautious, disengaged, doubtful and dismissive about climate change. 72% are alarmed, concerned or cautious! Source: https://climatecommunication.yale.edu/about/projects/global-warmings-six-americas/
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Katharine Hayhoe @katharinehayhoe.com · 19/01/2025
Researchers found 15 people in Kansas City who had changed their mind about climate change, and asked them why. Fascinating! link.springer.com/article/10.1...
A quote from the paper stating that their results extend my advice about the importance of talking about climate change
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Jatin Nagpal @jatinnagpal.bsky.social · 18/01/2025
Mechanosensation of the heart and gut elicits hypometabolism and vigilance in mice | Nature Metabolism www.nature.com/articles/s42...
nature.com
Mechanosensation of the heart and gut elicits hypometabolism and vigilance in mice - Nature Metabolism
Scott, Tan et al. characterize the neural circuits that link mechanic stimuli in the heart and gut with whole-body energy homeostasis and vigilance.
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Lizzie Manning @drlizziemanning.bsky.social · 17/01/2025
Exciting new data on psilocybin effects on hypothalamic CRH neurons @gergelyturi.bsky.social Tamas Füzesi & @stressynomics.bsky.social www.biorxiv.org/content/10.1...
biorxiv.org
Psilocybin induces sex- and context-specific recruitment of the stress axis
Psychedelics have reemerged as potential treatments for mental health disorders, yet their impact on stress-related brain regions remains poorly understood. Here, we provide the first real-time, in vi...
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Eric Topol @erictopol.bsky.social · 14/01/2025
Dirty air, dementia, and other adverse brain effects www.nature.com/articles/d41... new Feature @nature.com open-access
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Dan Semenza @daniel-semenza.bsky.social · 14/01/2025
New study out now in SS&M from our team @njgvrc.bsky.social! Both frequency + recency of gun violence exposure influence mental health and suicide. More national evidence of the extensive toll that gun violence takes on our collective health and well-being. www.sciencedirect.com/science/arti...
sciencedirect.com
Frequency, recency, and variety of gun violence exposure: Implications for mental health and suicide among US adults
Gun violence exposure (GVE) is a pervasive public health issue in the United States, with significant implications for mental health. This study exami…
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Mick Craig @mickcraig.bsky.social · 11/01/2025
My new year's resolution was to work through the pile of almost-finished papers so... #PrePrintAlert #NeuroSkyence. This is an update to one we put out late 2021, which got delayed with Lilya (lead author) going on maternity leave (yay, lab baby! 🥰). A brief 🧵 1/ www.biorxiv.org/content/10.1...
biorxiv.org
Hippocampus does not appear to be a major target of thalamic nucleus reuniens
The prefrontal - hippocampal - entorhinal system is perhaps the most widely-studied circuit in cognitive and systems neuroscience, due to its role in supporting cognitive functions such as working mem...
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Joeri Bordes @joeribordes.bsky.social · 20/12/2024
We've uncovered sex-specific effects of early-life stress (ELS) exposure on fear memory, HPA-axis regulation, and brain metabolism🧠. Unsupervised clustering shows that fear responses are more than only freezing. @mathiasvschmidt.bsky.social nature.com/articles/s42... Highlights in thread👇
nature.com
Sex-specific fear acquisition following early life stress is linked to amygdala and hippocampal purine and glutamate metabolism - Communications Biology
This study models early life stress (ELS) to observe sex-specific effects on fear memory formation using innovative unsupervised classification together with cellular metabolism alterations in key str...
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Gavin Schmidt @climateofgavin.bsky.social · 10/01/2025
All surface temperature products for 2024 are now live. All show 2024 is the warmest year (very clearly). The estimates of the change since the pre-industrial (1850-1900) are more uncertain but range from 1.46 to 1.62ºC. It is therefore *likely* this was the first year that exceeded 1.5ºC.
five time series of global mean surface temperature changes starting low and noisy in the 1850s - rising clearly since the 1960s - and showing 2024 was clearly the warmest.
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Dr. Nikki Crowley @nicoleacrowley.bsky.social · 10/01/2025
The Conversation asked me to share my thoughts on the new U.S. Surgeon General Advisory around alcohol and cancer & to break down some of the science in an accessible way. Check it out here: theconversation.com/even-1-drink...
theconversation.com
Even 1 drink a day elevates your cancer risk – an expert on how alcohol affects the body breaks down a new government report
The government linked alcohol with seven types of cancers, prompting the US surgeon general to call for warning labels on beer, wine and liquor.
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Natalie hauglund @nataliehauglund.bsky.social · 10/01/2025
Out in @cellcellpress.bsky.social ! We show that oscillations in norepinephrine and cerebral blood volume are the missing pieces that link NREM sleep to clearance of waste from the brain 🧠💤 www.cell.com/cell/fulltex...
cell.com
Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep
Norepinephrine oscillations during NREM sleep drive synchronized changes in cerebral blood volume and cerebrospinal fluid, promoting glymphatic clearance. Optogenetic and pharmacological manipulations confirm that vasomotion, regulated by norepinephrine, acts as a pump for brain fluid transport.
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Katharine Hayhoe @katharinehayhoe.com · 09/01/2025
I define hope as the belief that our actions can make a difference. For me, it's not an emotion but rather a daily practice. Every week I share good news of climate solutions, not-so-good news on how climate change is affecting our lives, and something concrete we can do about it. Subscribe here:
talkingclimate.ca
Talking Climate | Katharine Hayhoe | Substack
Subscribe to Katharine's newsletter for a clear-eyed and hopeful look at climate science and solutions. Receive weekly climate updates, good climate news, event information, ideas on things to do and ...
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Waggoner Lab @labwaggoner.bsky.social · 08/01/2025
Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep @cellcellpress.bsky.social @nataliehauglund.bsky.social www.cell.com/cell/fulltex...
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Katharine Hayhoe @katharinehayhoe.com · 08/01/2025
Climate change is creating warmer, drier conditions that cause fire seasons in some regions like western North America to last longer and be more active. Read more:
nature.org
Yes, Climate Change is Raising the Risks—and Stakes—of Extreme Wildfires
Rising temperatures, parched forests, and shifting precipitation patterns are fueling severe wildfires with unprecedented impacts. There is still time to act.
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Deb Chachra @debcha.bsky.social · 09/01/2025
Occasional reminder that there’s no, “it’s too late, its over” for anthropogenic climate change. Every molecule of CO2 that doesn’t go into the atmosphere makes a difference. Preventing 0.1 degree of warming makes a difference. Every bit of climate resilience we build together makes a difference.
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Max Kennerly @maxkennerly.bsky.social · 08/01/2025
To everyone's surprise, it turns out that attaching a money-sucking machine to a hospital system makes it worse.
nbcnews.com
Private equity reduces patient care while enriching investors, Senate report finds
The bipartisan investigation of hospital systems purchased by Apollo Global Management and Leonard Green & Partners reinforced the findings of past academic research.
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Science Magazine @science.org · 07/01/2025
Light can influence metabolism independent of the circadian clock, according to a new #ScienceAdvances study in mice. Learn more: scim.ag/3DIu7bP
scim.ag
Light modulates glucose and lipid homeostasis via the sympathetic nervous system
Light exerts circadian-independent effects on glucose and lipid metabolism.
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Rebecca Hendrickson MD, PhD @hendricksonmd.bsky.social · 08/01/2025
The violence point is interesting to me....
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Rebecca Hendrickson MD, PhD @hendricksonmd.bsky.social · 07/01/2025
Similarly, GBD is by no means a perfect measure either - bc it emphasizes years lost or lived with disability it weights dementia much lower in impact than most would who've lived its impact on a family member or with the possibility of it hanging over them.
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Rebecca Hendrickson MD, PhD @hendricksonmd.bsky.social · 07/01/2025
This is interesting but in some ways misleading. Eg, by separating "depression" from "mdd" (and also andedonia) it makes it look like we're overemphasizing one and underemphasizing another, but most of the foundational work is the same. 1/2
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Usha Lee McFarling @usha.bsky.social · 06/01/2025
Just published: FDA puts out new guidelines, include testing on more subjects with all ranges of skin colors, to improve the accuracy of pulse oximeters in people with darker skin. Said one source: FDA is now really clearly addressing the issue of racial bias. www.statnews.com/2025/01/06/p...
statnews.com
FDA releases long-awaited guidance to improve accuracy of pulse oximeters for all skin tones
The FDA released long-awaited guidance proposing how manufacturers should test and label pulse oximeters
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Rebecca Hendrickson MD, PhD @hendricksonmd.bsky.social · 06/01/2025
This isn't really new. Take SSRIs: there's a long history of work suggesting a portion of their effect comes from impacts on BDNF/neuroplasticity. We talk about how this may increase your ability to respond in a new way to your environment. Why wouldn't we assume interaction is likely?
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Rebecca Hendrickson MD, PhD @hendricksonmd.bsky.social · 06/01/2025
The idea that we need to shift from assuming pharmacotherapies have effects that are separable from the context in which they're taken is one I agree with. In fact, the significant majority of the medications I prescribe there is evidence to suggest important drug-context interactions.
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Max Wolff @trpwolff.bsky.social · 04/01/2025
I encourage everyone to read through Compass' latest description of their "psychological support" model. If this is not in fact psychotherapy, then nothing is. Ironically, this is most evident whenever the authors apparently aim to differentiate their model from (their idea of) psychotherapy, e.g.:
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Christian Staehr @chrstaehr.bsky.social · 02/01/2025
🚨 Breaking #Physiology news: Spinal arteries dilate in response to #noradrenaline! Our new study (www.thespinejournalonline.com/article/S152... ) shows increased spinal cord blood flow in-vivo via β-adrenergic receptor–mediated vasodilation, as spinal arteries lack α1-adrenergic receptors.
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Daniel P. Moriarity @dpmoriarity.bsky.social · 04/01/2025
"A study of federally funded research projects in the United States estimated that principal investigators spend on average about 45% of their time on administrative activities related to applying for and managing projects rather than conducting active research" www.pnas.org/doi/10.1073/...
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Carolina Rezaval @crezaval.bsky.social · 15/11/2024
Sex or survival—what’s more important? Excited to share our @Nature paper on how flies resolve this conflict. We found a dopamine-based filter that reduces threat perception, helping flies focus on courtship when close to mating. www.nature.com/articles/s41...
nature.com
Mating proximity blinds threat perception - Nature
A state-dependent dopamine filter system in the male Drosophila brain balances threat perception against the drive to mate.
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Nora Verlaine @noraverlaine.bsky.social · 24/12/2024
“Women are asked more questions during a seminar and the questions asked of women presenters are more likely to be patronizing or hostile. These effects are not due to women presenting in different fields, different seminar series, or different topics…” www.nber.org/papers/w28494
nber.org
Gender and the Dynamics of Economics Seminars
Founded in 1920, the NBER is a private, non-profit, non-partisan organization dedicated to conducting economic research and to disseminating research findings among academics, public policy makers, an...
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Rebecca Hendrickson MD, PhD @hendricksonmd.bsky.social · 20/12/2024
I feel like it's the first year it's been done this way, so makes sense if it was a bit inconsistent I guess.
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Rebecca Hendrickson MD, PhD @hendricksonmd.bsky.social · 20/12/2024
This year the tickets were actually needed if you wanted a non-alcoholic drink also (as some of us discovered after giving our away!). I did appreciate that they had a featured mocktail, though. It feels like it's less alcohol focused each year. I appreciate the progress.
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