Reposted by Victor Yin
🕷️ Spiders from our blood 🕷️
Check out our new paper from @hecklab.bsky.social describing how the spider-like immune regulator C4BP interacts with its native binding partners.
🔗 www.mcponline.org/article/S153...
#MassSpec #StructuralBiology
mcponline.org
Structural Insights into Complement Inhibition: Visualizing Distinct Binding Modes of C4b-binding Protein Complexes with C4b and SAP
C4b-binding protein (C4BP) is an innate immune inhibitor found in serum. Human C4BP
adopts spider-like higher-order structures (HOS) formed by disulfide-linked C4BPα
and C4BPβ chains that non-covalent...
