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Harrold van den Burg

@havandenburg.bsky.social
149 followers 144 following 3 posts

Research manager Biotechnology Rijk Zwaan | Special chair in Plant pathology | University of Amsterdam | Plant Virology | Xanthomonas | Plant disease susceptibility | Messages are my own

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Reposted by Harrold van den Burg
pfeilmeier.bsky.social @pfeilmeier.bsky.social · 04/11/2025
We wrote a review 📖 on hydathode immunity! Learn how bacteria exploit hydathodes to access the vasculature and open questions for future research. 📣 If you are curious about this topic, please consider applying for two open positions in my lab (until Nov23)! www.sciencedirect.com/science/arti...
sciencedirect.com
Hydathodes at the forefront of plant immunity against vascular pathogens
Hydathodes are tiny plant organs that form an interface between the leaf surface and xylem vasculature. They facilitate excretion of xylem fluid under…
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Reposted by Harrold van den Burg
Bruno Ngou @brunongou.bsky.social · 04/09/2025
Very happy to share our latest work “Systematic discovery and engineering of synthetic immune receptors in plants” out in @science.org ! www.science.org/doi/10.1126/...
science.org
Systematic discovery and engineering of synthetic immune receptors in plants
Plants deploy a diverse array of pattern recognition receptors (PRRs), which perceive microbe-associated molecular patterns to activate immune responses. Leucine-rich repeat receptor-like kinase subgr...
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Reposted by Harrold van den Burg
pfeilmeier.bsky.social @pfeilmeier.bsky.social · 29/07/2025
Finally a method to identify plant RNA-binding proteins! 🧬 This enables so much new biology to discover from immunity to development! 🤯 🪴 Established by the incredible Victor Sanchez with @havandenburg.bsky.social @uva.nl Congratulations!!
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Reposted by Harrold van den Burg
Marco Incarbone @incavirus.bsky.social · 28/07/2025
www.nature.com/articles/s41... Brilliant new strategy to obtain broad resistance against Potyviruses, and possibly other protease-encoding viruses
nature.com
Remodelling autoactive NLRs for broad-spectrum immunity in plants - Nature
Cleavage by pathogen-derived proteases of an engineered chimeric protein activates its plant immune receptor component, enabling broad-spectrum resistance to pathogens in plants.
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Reposted by Harrold van den Burg
pfeilmeier.bsky.social @pfeilmeier.bsky.social · 02/07/2025
Hydathode immunity 🌱 - the discovery journey continues ... ⏩ Today: Immune receptor SUT1 confers resistance against #Xanthomonas pathogens in hydathodes. In the latest version, we contrast the tissue-specificity of SUT1 with the well-known ZAR1 resistance. journals.plos.org/plospathogen...
journals.plos.org
Arabidopsis CNL receptor SUT1 confers immunity in hydathodes against the vascular pathogen Xanthomonas campestris pv. campestris
Author summary Black rot disease, caused by the bacterial pathogen Xanthomonas campestris pv. campestris (Xcc), is an economically important disease of cabbage crops. Xcc is unique in that it enters t...
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Reposted by Harrold van den Burg
AmirAli Toghani @amiralito.bsky.social · 09/05/2025
Happy to share that our Helixer deeplearning-based annotation of 230 superasterid genomes is now online on @datadryad.bsky.social 💻🌱 doi.org/10.5061/drya... Check out how we used 69 of them to study the molecular evolution of a plant immune receptor network here! 👇
doi.org
Dryad | Data -- Deep-learning-based annotation of 230 superasterid genomes reveals a harmonized dataset of 91,366 NLRs
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Reposted by Harrold van den Burg
Danve Castroverde @danvec.bsky.social · 21/04/2025
Reciprocal phosphorylation between SOAK1 and SOBIR1 fine-tunes receptor-like protein (RLP)–mediated plant immunity @science.org #ScienceAdvances www.science.org/doi/10.1126/...
science.org
Reciprocal phosphorylation between SOAK1 and SOBIR1 fine-tunes receptor-like protein (RLP)–mediated plant immunity
SOAK1-SOBIR1 module fine-tunes receptor-like protein (RLP)–mediated plant immunity.
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Reposted by Harrold van den Burg
Science Magazine @science.org · 10/04/2025
Huanglongbing causes crop damage worth $10 billion annually, and most trees die within a few years once infected. This week in a new Science study, researchers report that they have developed therapeutic peptides that may be able to save and revive infected citrus trees. scim.ag/4jtM8dC
Huanglongbing (HLB)—also called citrus greening—is a devastating bacterial disease of citrus trees spread by the Asian citrus psyllid. HLB causes crop damage worth 10 billion US dollars annually, and most trees die within a few years once infected. Researchers have uncovered a resistance mechanism against HLB and developed therapeutic peptides that may be able to save and revive infected citrus trees.
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Reposted by Harrold van den Burg
Karim Majzoub @karimaj.bsky.social · 07/04/2025
Beautiful paper
science.org
Exogenous RNA surveillance by proton-sensing TRIM25
Exogenous messenger RNAs (mRNAs) require cellular machinery for delivery and translation but also encounter inhibitory factors. To investigate their regulation, we performed genome-wide CRISPR screens...
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Reposted by Harrold van den Burg
Beuzón & Ruiz-Albert Lab @type3lab.bsky.social · 03/04/2025
How Bacteria Outsmart Plants—Then Flee the Scene! #MicroSky #PlantScience #Pseudomonas Our new research in Nature Microbiology uncovers the sophisticated teamwork of Pseudomonas syringae, a notorious plant pathogen. 🔗 rdcu.be/egczU
rdcu.be
Pseudomonas syringae subpopulations cooperate by coordinating flagellar and type III secretion spatiotemporal dynamics to facilitate plant infection
Nature Microbiology - Single-cell gene expression analysis reveals phenotypic heterogeneity to enable bacterial specialization over the course of plant colonization.
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Reposted by Harrold van den Burg
Vijay G. Sankaran @bloodgenes.bsky.social · 04/04/2025
Delighted to have our Perturb-multiome paper, led by #JorgeMartinRufino and @hemagene.bsky.social from our lab, published today in @science.org. Please check out this powerful approach to decipher gene regulatory networks enriched for genetic variation: www.science.org/doi/10.1126/...
science.org
Transcription factor networks disproportionately enrich for heritability of blood cell phenotypes
Most phenotype-associated genetic variants map to noncoding regulatory regions of the human genome, but their mechanisms remain elusive in most cases. We developed a highly efficient strategy, Perturb...
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Reposted by Harrold van den Burg
Broad Institute @broadinstitute.org · 05/04/2025
David Liu receives Breakthrough Prize in Life Sciences. Liu is honored for the development of base editing and prime editing, two gene editing technologies transforming medicine. www.broadinstitute.org/news/david-l...
broadinstitute.org
David Liu receives Breakthrough Prize in Life Sciences
Liu is honored for the development of base editing and prime editing, two gene editing technologies transforming medicine.
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Reposted by Harrold van den Burg
Sebastian Schornack @dromius.bsky.social · 28/03/2025
Le Naour--Vernet et al. Structure‐guided insights into the biology of fungal effectors nph.onlinelibrary.wiley.com/doi/full/10.... featuring MycFOLD effectors
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Reposted by Harrold van den Burg
Kenichi Tsuda @kenichitsuda.bsky.social · 28/03/2025
Oh yes. This is new. Non-NLR and NLR pair for immune sensor and executor! www.science.org/doi/10.1126/... www.science.org/doi/10.1126/...
science.org
A wheat tandem kinase and NLR pair confers resistance to multiple fungal pathogens
Tandem kinase proteins underlie the innate immune systems of cereal plants, but how they initiate plant immune responses remains unclear. This report identifies wheat protein wheat tandem NBD 1 (WTN1)...
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Reposted by Harrold van den Burg
Marco Trujillo @trujillolab.bsky.social · 18/02/2025
Yes, that's a proteasome! Guess where it is....in the apoplast! Nice to see Richard Vierstra's work out! #PPStasis #proteostasis #proteasomes #PlantSci www.nature.com/articles/s41...
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Reposted by Harrold van den Burg
parkergroup.bsky.social @parkergroup.bsky.social · 13/02/2025
Check out our new study! We show that Arabidopsis uses the EDS1-SAG101-NRG1 node to trigger rapid yet contained cell death. Key finding: NRG1C variant regulates this process by competing with functional NRG1s. Amazing collaboration between Jijie Chai and Parker Labs. www.nature.com/articles/s41...
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Harrold van den Burg @havandenburg.bsky.social · 10/02/2025
Great new study from our lab revealing insights in Xanthomonas evolution and how loss of the Crispr genome defense was a key step for X. campestris pv campestris.
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Reposted by Harrold van den Burg
pfeilmeier.bsky.social @pfeilmeier.bsky.social · 03/02/2025
Lighten up your life! We built a “darkbox” with a CCD camera to image bacterial infections across entire trays of Arabidopsis plants. Our technical advance with Python image analysis pipeline out now! @havandenburg.bsky.social @nwtaks.bsky.social bsppjournals.onlinelibrary.wiley.com/doi/10.1111/...
bsppjournals.onlinelibrary.wiley.com
Non‐Invasive, Bioluminescence‐Based Visualisation and Quantification of Bacterial Infections in Arabidopsis Over Time
Development of a non-invasive high-throughput phenotyping pipeline to visualise and quantify progression of bioluminescent bacterial pathogens in Arabidopsis rosettes over time.
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