Reposted by Alexis CaulierScience Magazine @science.org · 08/05/2026Rather than being the product of a churning, molten core, Ganymede’s dynamo may be powered by a core that is still forming, researchers report. Learn more: scim.ag/4etP0rF 0539
Alexis Caulier @hemagene.bsky.social · 04/05/2026I am happy to share that Perturb-Multiome ATAC fragment files (www.science.org/doi/10.1126/...) are now available on our GEO repository. 🧬👩💻 👉 (www.ncbi.nlm.nih.gov/geo/query/ac...) #SankaranLab #Multiome #Perturbationscreenncbi.nlm.nih.gov GEO Accession viewer NCBI's Gene Expression Omnibus (GEO) is a public archive and resource for gene expression data. 020
Alexis Caulier @hemagene.bsky.social · 01/05/2026What a beautiful work from my friend Peng Lyu in #SankaranLab, demonstrating how non-coding transcribed genetic information can rewire HSCs and modulate the risk to develop blood malignancies! www.sciencedirect.com/science/arti...sciencedirect.comGenetic variation reveals a homeotic long noncoding RNA that modulates human hematopoietic stem cellsThe HOXA gene locus coordinates body patterning, hematopoiesis, and differentiation. While studying blood phenotype-associated variation within the HO… 040
Reposted by Alexis CaulierWaggoner Lab @labwaggoner.bsky.social · 18/04/2025Systemic inflammation impairs myelopoiesis and interferon type I responses in humans www.nature.com/articles/s41... @natimmunol.bsky.social 0226
Reposted by Alexis CaulierScience Magazine @science.org · 18/04/2025There’s an arms race going on between a disease-causing fungus and its host, and it’s not the one portrayed in HBO’s postapocalyptic series The Last of Us. #ScienceMagArchives scim.ag/42QS3Unscim.agArms race between ants and fungi has echoes of The Last of UsInsects are fighting off fungal invaders, but the fungi have some tricks up their sleeve 05913
Reposted by Alexis CaulierScience Magazine @science.org · 18/04/2025The Science Visuals team has been honored with three @commarts.com Awards of Excellence. These prestigious awards recognize creative excellence and outstanding execution in visual storytelling. (THREAD 🧵) scim.ag/4jDJ6TYscim.agScience Visuals honored with three Communication Arts AwardsThe prestigious awards recognize creative excellence and outstanding execution in visual storytelling. 18413
Alexis Caulier @hemagene.bsky.social · 16/04/2025A great ressource from the Khoriaty lab at University of Michigan to understand deeper the molecular regulation of erythropoiesis, this week in @natcomms.nature.com www.nature.com/articles/s41...nature.comA genome-wide screen identifies genes required for erythroid differentiation - Nature CommunicationsUsing a genome-wide CRISPR knock-out screen, the authors defined the repertoire of genes that are required for proerythroblast survival and for terminal erythroid differentiation. 020
Reposted by Alexis CaulierNature Biotechnology @natbiotech.nature.com · 03/04/2025Scalable spatial transcriptomics through computational array reconstruction - @broadinstitute.org go.nature.com/3QYfSDdgo.nature.comScalable spatial transcriptomics through computational array reconstruction - Nature BiotechnologyAn imaging-free spatial transcriptomics method facilitates high-throughput barcode array generation up to centimeter scale. 1349
Alexis Caulier @hemagene.bsky.social · 03/04/2025Our work nicely complements recently released papers from @thenormanlab www.cell.com/cell-systems... and @satijalab www.nature.com/articles/s41... that describe the value of multimodal perturb-seq using CRISPRi in cell lines to decipher gene regulatory networks ! 🧬 🧫 000
Alexis Caulier @hemagene.bsky.social · 03/04/2025Out today in @science.org! What if you could chart cells' regulatory programs at unprecedented resolution? In my work with Jorge Martin-Rufino from the @bloodgenes.bsky.social lab, we dissect the genome’s control circuits and find where key genetic variation hides bit.ly/3YhBMoObit.lyTranscription factor networks disproportionately enrich for heritability of blood cell phenotypesMost phenotype-associated genetic variants map to noncoding regulatory regions of the human genome, but their mechanisms remain elusive in most cases. We developed a highly efficient strategy, Perturb... 45117
Reposted by Alexis CaulierDana-Farber News @danafarbernews.bsky.social · 06/03/2025Congratulations to @danafarber.bsky.social’s Lara Wahlster, MD, PhD, and Nina Weichert-Leahey, MD, for receiving the American Society for Clinical Investigation Emerging-Generation Awards. Read about Dr. Wahlster at bit.ly/4haxdTW and Dr. Weichert-Leahey at bit.ly/4h6BYxL. 042
