Sign in

hardcastlelab.bsky.social

@hardcastlelab.bsky.social
76 followers 82 following 26 posts

Professor of Molecular Genetics, Deputy Director, UCL Institute of Ophthalmology likes genomes and the natural world

PostsRepliesMedia
Reposted by @hardcastlelab.bsky.social
NIHR Biomedical Research Centre: Moorfields @moorfieldsbrc.bsky.social · 07/09/2026
Explore our free on-demand PPIE and EDI courses, open to all researchers Involving patients and the public boosts research quality and ethics. Engaging them in decision-making leads to innovative solutions and improved outcomes. 🔗 buff.ly/1qK8d2E @moorfields.bsky.social @ucleye.bsky.social
Promotional graphic from the National Institute for Health and Care Research (NIHR) advertising free on demand PPIE and EDI courses for researchers. The graphic features a photograph of people seated in a group discussion and includes the text: "open to all", "PPIE and EDI free on-demand courses available for researchers", and "NIHR Biomedical Research Centre: Moorfields". A "20 Years" anniversary logo appears in the bottom right corner.
111
Reposted by @hardcastlelab.bsky.social
Aaron Quinlan (he/him) @aaronquinlan.bsky.social · 28/08/2026
I am delighted to announce that The Department of Human Genetics at the University of Utah is continuing a multi-year recruiting initiative for multiple tenure-track faculty positions at the rank of Assistant Professor. Please share and consider applying! utah.peopleadmin.com/postings/208...
183102
Reposted by @hardcastlelab.bsky.social
Kristen Kwan @blockintheback.bsky.social · 21/08/2026
📣 The Department of Ophthalmology and Visual Sciences @utah.edu is recruiting! We seek researchers addressing exciting questions in vision science using innovative approaches. Join our community @moraneyecenter.bsky.social! Repost and contact me with questions! utah.peopleadmin.com/postings/206...
02723
Reposted by @hardcastlelab.bsky.social
Adam Rutherford @adamrutherford.bsky.social · 20/07/2026
Tonight at the @unionchapeluk.bsky.social, @davidolusoga.bsky.social and I will be chewing the fat about history, genetics, racism, giant ground sloths, Daddy Dyer, you know, the normal stuff. Come along. unionchapel.org.uk/venue/whats-...
unionchapel.org.uk
Union Chapel
Union Chapel is a church, live entertainment venue and charity drop-in centre for the homeless in Islington, London, England. Built in the late 19th century in the Gothic revival style, the church is ...
2254
Reposted by @hardcastlelab.bsky.social
Matteo Carandini @carandinilab.net · 13/07/2026
My home institute, @ucleye.bsky.social, is looking for a new Director! www.veredus.co.uk/job/job-1183a/
veredus.co.uk
Director of the UCL Institute of Ophthalmology - REF 1183 | Veredus
University College London Director of the UCL Institute of Ophthalmology  Location: London Salary: An attractive remuneration package UCL is a world leading, global university with a community of more...
0810
Reposted by @hardcastlelab.bsky.social
UCL Institute of Ophthalmology @ucleye.bsky.social · 30/06/2026
See what life will be like when we move to Moorfields and UCL Centre for Eye Health next year: featuring project partners and a first look at the rooftop terrace. www.youtube.com/watch?v=waGX...
youtube.com
Moorfields and UCL Centre for Eye Health site film - June 2026
YouTube video by Oriel London
021
Reposted by @hardcastlelab.bsky.social
Mike Cheetham @cheethamlab.bsky.social · 29/06/2026
Love vision and want to help cure disease? We have a vacancy tor a post-doc come and join our team! www.ucl.ac.uk/work-at-ucl/...
ucl.ac.uk
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
022
Reposted by @hardcastlelab.bsky.social
UCL Institute of Ophthalmology @ucleye.bsky.social · 29/06/2026
We have two Research Fellow vacancies available to join @cheethamlab.bsky.social at @ucleye.bsky.social. The Research Fellows will explore molecular mechanisms of retinal degeneration and test potential therapeutic approaches. These positions close on 8 July. www.ucl.ac.uk/work-at-ucl/...
ucl.ac.uk
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
035
Reposted by @hardcastlelab.bsky.social
Adam Rutherford @adamrutherford.bsky.social · 22/06/2026
God i LOVE experts. This is GLORIOUS.
727664
Reposted by @hardcastlelab.bsky.social
Adam Rutherford @adamrutherford.bsky.social · 11/06/2026
Me and @davidolusoga.bsky.social at the Union Chapel, 20th July, talking history, prehistory, and the unwelcome return of scientific racism. I went to Björk performing by candlelight at the Union Chapel once. Quite chuffed about this. unionchapel.org.uk/venue/whats-...
unionchapel.org.uk
Union Chapel
Union Chapel is a church, live entertainment venue and charity drop-in centre for the homeless in Islington, London, England. Built in the late 19th century in the Gothic revival style, the church is ...
3598
Reposted by @hardcastlelab.bsky.social
NIHR Biomedical Research Centre: Moorfields @moorfieldsbrc.bsky.social · 01/05/2026
Congratulations to Prof Andrew Dick on his appointment as UCL's Dean of the Faculty of Brain Sciences. As our BRC co-director, Andrew plays a pivotal role in driving translational research that improves outcomes for patients with eye disease. We can't wait to see him flourish in this new role!
062
Reposted by @hardcastlelab.bsky.social
The Cosmic Shambles Network @cosmicshambles.com · 24/04/2026
Come celebrate UCL's 200th birthday with a very special Shambles event on May 6th with physicists, Olympians, biochemists, musicians, comedians and more!! thecosmicshamblesnetwork.substack.com/p/cosmic-ucl
thecosmicshamblesnetwork.substack.com
Cosmic UCL
We're teaming up with UCL for a special night to celebrate 200 years of University College London
0119
Reposted by @hardcastlelab.bsky.social
Tom Burgoyne Lab @tomburgoynelab.bsky.social · 30/03/2026
Our new paper is out today in @arvoiovs.bsky.social We provide evidence that the connecting cilium rootlet in mouse photoreceptors may act as a scaffold that supports ER positioning, enabling it to branch and form membrane contact sites with other cellular membranes. @ucleye.bsky.social
iovs.arvojournals.org
The P23H Rhodopsin Mouse Model Reveals a Novel Interaction Between the Endoplasmic Reticulum and Connecting Cilium Rootlet Within Photoreceptors | IOVS | ARVO Journals
033
Reposted by @hardcastlelab.bsky.social
UCL Institute of Ophthalmology @ucleye.bsky.social · 25/03/2026
We are thrilled that our new centre for eye care, research, and education will be called Moorfields and UCL Centre for Eye Health. We will be moving to the new centre in 2027 alongside our colleagues at Moorfields Eye Hospital and Moorfields Eye Charity. www.ucl.ac.uk/news/2026/ma...
072
Reposted by @hardcastlelab.bsky.social
UCL Ear Institute @uclearinstitute.bsky.social · 24/03/2026
📣Job alert deadline extension📣 The Lecturer (Teaching) in Audiology role that we are recruiting for at the EI now has a deadline of 10th April! If you know anyone who might be interested in or appropriate to apply, further information is here: www.ucl.ac.uk/work-at-ucl/...
ucl.ac.uk
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
012
Reposted by @hardcastlelab.bsky.social
PacBio @pacbio.bsky.social · 17/02/2026
Meet Elfride De Baere, Head of Clinic at Ghent University Hospital’s Center for Medical Genetics. She shares why PacBio long-read sequencing + a multiomic approach (genomics + transcriptomics) can help deliver clearer insights for families. #WeCareForRare #RareDiseaseMonth #GeneticEyeDisease
083
Reposted by @hardcastlelab.bsky.social
Ian Sudbery @iansudbery.bsky.social · 01/02/2026
We need to be shouting about the effects of this on junior researchers from the roofs, writing to our MPs. We are risking a "missing generation" of researchers.
Text reads:

This would likely end the careers of hundreds of postdocs across the country, they added, highlighting that the suspensions alone will "tank" the postdoc market by the end of the summer and into next year.
12119
Reposted by @hardcastlelab.bsky.social
IOB - Institute of Molecular and Clinical Ophthalmology Basel @iobswiss.bsky.social · 09/01/2026
🧬 Major breakthrough: IOB researchers identify new genetic cause of inherited blindness in overlooked RNA genes. The discovery solves decades-old diagnostic mystery and opens new pathways for many patients worldwide. ➡️ www.nature.com/articles/s41... #AcademicBlueSky #Genetics #VisionResearch #IRDs
01611
Reposted by @hardcastlelab.bsky.social
Stefan Barakat @stefanbarakat.bsky.social · 09/01/2026
New international collaborative work (incl us) just out in @natgenet.nature.com showing how dominant variants in RNU genes like RNU4-2 can also cause Retinitis Pigmentosa Mathieu Quinodoz, Kim Rodenburg, Susanne Roosing, @carlorivolta.bsky.social & many others www.nature.com/articles/s41...
073
Reposted by @hardcastlelab.bsky.social
Stefan Barakat @stefanbarakat.bsky.social · 06/12/2025
another great international collaboration with our friends in UK and Australia to which we could contribute, describing a very unique disease mechanism for a novel neurodegenerative disorder #genetics #raredisease @ajhgnews.bsky.social @jamesfasham.bsky.social @rdexeter.bsky.social
095
hardcastlelab.bsky.social @hardcastlelab.bsky.social · 17/09/2025
Amazing science being presented @rd2025.bsky.social including from our team @ucleye.bsky.social 🧫🧬🧪🔬
021
hardcastlelab.bsky.social @hardcastlelab.bsky.social · 17/09/2025
We’ll done Davide 👏 excellent talk @rd2025.bsky.social
021
hardcastlelab.bsky.social @hardcastlelab.bsky.social · 17/09/2025
We’ll done Owen 👏 great talk at @rd2025.bsky.social in Prague
021
Reposted by @hardcastlelab.bsky.social
UCL Institute of Ophthalmology @ucleye.bsky.social · 16/09/2025
A new drug for a rare genetic disease that can lead to sudden loss of vision has been approved for NHS patients after a successful clinical trial co-led by Dr Patrick Yu-Wai-Man @ucleye.bsky.social & Moorfields Eye Hospital NHS. Supported by @moorfieldsbrc.bsky.social. www.ucl.ac.uk/news/2025/se...
ucl.ac.uk
Treatment for cause of sight loss approved following UCL research
A novel treatment for Leber’s Hereditary Optic Neuropathy (LHON), a rare genetic disease that can lead to sudden loss of vision, has been approved for NHS patients following a successful clinical trial co-led by UCL and Moorfields researcher.
032
Reposted by @hardcastlelab.bsky.social
The American Journal of Human Genetics @ajhgnews.bsky.social · 16/09/2025
Explore the new resource!
retigene.erdc.info
IRD Gene Atlas
021
Reposted by @hardcastlelab.bsky.social
IOB - Institute of Molecular and Clinical Ophthalmology Basel @iobswiss.bsky.social · 17/09/2025
🧬 How can we navigate the genetic complexity of inherited retinal diseases? Our new paper in @ajhgnews.bsky.social presents RetiGene, a curated atlas of IRD genes, built with @erdc-team.bsky.social, to support diagnosis, research and therapy. 👉 bit.ly/467U1S9 #AcademicBlueSky #IRDs #VisionResearch
186
Reposted by @hardcastlelab.bsky.social
UCL Institute of Ophthalmology @ucleye.bsky.social · 27/08/2025
Congratulations to @ucleye.bsky.social's Professor @pearsekeane.bsky.social on receiving the @royalsociety.org's prestigious Gabor Medal for his contributions to advancing retinal image analysis through AI for the diagnosis of eye disease. www.ucl.ac.uk/brain-scienc...
ucl.ac.uk
Congratulations to Professor Keane on being awarded the Gabor Medal
The Gabor Medal is awarded annually by The Royal Society for distinction of interdisciplinary work between the life sciences with other disciplines.
031
Reposted by @hardcastlelab.bsky.social
UCL Institute of Ophthalmology @ucleye.bsky.social · 26/08/2025
We are seeking a Research Fellow / Senior Research Fellow to work with Professor Marinko Sarunic’s group at @ucleye.bsky.social and UCL Medical Physics & Biomedical Engineering. Closes 2 September. www.ucl.ac.uk/work-at-ucl/...
https://ye.bsky.social‬
001
Reposted by @hardcastlelab.bsky.social
Sten Linnarsson @sten.linnarsson.org · 25/06/2025
A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)
2116109
Reposted by @hardcastlelab.bsky.social
Adam Rutherford @adamrutherford.bsky.social · 14/08/2025
An absolute scam. Does this serve science? No it does not. www.thebookseller.com/news/springe...
thebookseller.com
Springer Nature's revenue increases to €926m as adjusted operating profit soars
Springer Nature's group revenue has risen by 6% to €926m (£800m) in the first half of 2025, while adjusted operating profit (AOP) was up by 10% to €241m (£208m).
45916
Reposted by @hardcastlelab.bsky.social
Kevin Mitchell @wiringthebrain.bsky.social · 23/07/2025
Very pleased to say we have an Assistant Professor job opening (tenure track) in the Department of Genetics at Trinity College Dublin! 😀 www.jobs.ac.uk/job/DOA399/a... - deadline is August 19th! Please repost!
298123
Reposted by @hardcastlelab.bsky.social
UCL Institute of Ophthalmology @ucleye.bsky.social · 22/07/2025
Everyone at @ucleye.bsky.social has been deeply saddened by the passing of a highly esteemed colleague in June 2025. www.ucl.ac.uk/news/2025/ju...
ucl.ac.uk
Tribute to eye treatment pioneer Professor Pete Coffey
UCL colleagues have paid tribute to world-leading eye researcher Professor Pete Coffey, who pioneered a treatment enabling people whose vision had been destroyed by disease to see again.
0135
Reposted by @hardcastlelab.bsky.social
Alex Garanto @jandritu.bsky.social · 21/07/2025
👁‍🗨 We are seeking for a motivated and enthusiastic colleague to join our team. Do you want to know more? visit the link below ⬇️⬇️⬇️ www.radboudumc.nl/en/vacancies...
radboudumc.nl
Vacancy - PhD position on Advancing Personalized iPSC-Based Models for Inherited Retinal Diseases
The eye is the window to the world around us. Losing vision either early or late in life is a significant burden for patients. Nowadays, molecular ...
011
Reposted by @hardcastlelab.bsky.social
The Royal Society @royalsociety.org · 17/07/2025
Our new Faraday Discovery Fellowships Accelerated International Route provides a fast-track option for international mid-career researchers looking to relocate to the UK, providing up to £4m over a five-year period. Find out more: #RSGrants royalsociety.org/grants/farad...
royalsociety.org
Faraday Discovery Fellowships Accelerated International Route | Royal Society
The Faraday Discovery Fellowships Accelerated International Route provides a fast-track option for attracting mid-career researchers looking to relocate to the UK from overseas, providing up to £4m ov...
42227
hardcastlelab.bsky.social @hardcastlelab.bsky.social · 11/07/2025
Congratulations Freddie on your PhD defence 🎉🥳 huge thank to the examiners Chris Inglehearn and Dan Gore 🙏
031
Reposted by @hardcastlelab.bsky.social
Mill_lab @cilialab.bsky.social · 07/07/2025
In both roles, new recruits will be part of an interdisciplinary team that uses state-of-the-art technologies to develop transformative therapeutic targets as part of the LifeArc Centre for Rare Respiratory Diseases. Please DM to discuss opportunities further. 🧪🧪 /fin
001
Reposted by @hardcastlelab.bsky.social
Amanda Carr @amandajcarr.bsky.social · 07/07/2025
It’s incredibly hard to express what Professor Pete Coffey meant to so many of us. The Macular Society has written a beautiful tribute to Pete and I'm honoured to have contributed a few words. Thank you, my friend, for so many happy days. www.macularsociety.org/about/media/...
macularsociety.org
Tributes paid to pioneering eye researcher Professor Pete Coffey
Tributes have been paid to one of the world’s top eye researchers, Professor Pete Coffey, who has sadly passed away after a long illness.
3116
Reposted by @hardcastlelab.bsky.social
Alex Garanto @jandritu.bsky.social · 05/07/2025
Congrats Owen! And of course also to you and @cheethamlab.bsky.social! He did great & we had very interesting discussions! Thanks for the invitation & thinking about me as the external expert. I really enjoyed it! It was lovely to catch up with you! Thanks a lot for the hospitality!
131
Reposted by @hardcastlelab.bsky.social
Young lab @UCL @younglab.bsky.social · 04/07/2025
Check our latest paper... Variants in NR6A1 cause a novel oculo vertebral renal syndrome #RareDisease #Genetics #zebrafish #devbio www.nature.com/articles/s41...
nature.com
Variants in NR6A1 cause a novel oculo vertebral renal syndrome - Nature Communications
Colobomatous microphthalmia often lacks a genetic diagnosis despite its developmental complexity. Here, the authors show that rare variants in NR6A1 cause a syndromic form with eye, kidney, and verteb...
1102
Reposted by @hardcastlelab.bsky.social
Mike Cheetham @cheethamlab.bsky.social · 05/07/2025
Congratulations Owen and many thanks to Alex and Amanda.
162
hardcastlelab.bsky.social @hardcastlelab.bsky.social · 05/07/2025
Congratulations Owen on your PhD defence 🥳🎉🥂huge thank you to examiners @jandritu.bsky.social and @amandajcarr.bsky.social
221
Reposted by @hardcastlelab.bsky.social
UCL Institute of Ophthalmology @ucleye.bsky.social · 18/06/2025
Congratulations to @ucleye.bsky.social's Early Career Researcher (ECR) community for delivering another inspiring early career researchers' symposium last week, and to all recipients of the IoO ECR awards 2025. lnkd.in/gikiRGTF
083
Reposted by @hardcastlelab.bsky.social
Eric Topol @erictopol.bsky.social · 18/06/2025
A.I. is improving the accuracy of medical diagnoses. Today for inherited retinal diseases [IRD] (Eye2Gene vs retinal experts) nature.com/articles/s42...
35518
Reposted by @hardcastlelab.bsky.social
Amanda Carr @amandajcarr.bsky.social · 17/06/2025
Excited to be offering a new Macular Society funded UK PhD studentship at @ucleye.bsky.social with Giulia De Rossi. The project will investigate a new therapeutic target for fibrosis in age-related macular degeneration. Deadline for applications is 14th July. www.findaphd.com/phds/project...
findaphd.com
Understanding and targeting fibrosis in neovascular Age-related Macular Degeneration (AMD) at University College London on FindAPhD.com
PhD Project - Understanding and targeting fibrosis in neovascular Age-related Macular Degeneration (AMD) at University College London, listed on FindAPhD.com
173
Reposted by @hardcastlelab.bsky.social
NIHR Biomedical Research Centre: Moorfields @moorfieldsbrc.bsky.social · 30/05/2025
1 in 2000 young adults in the UK are affected by inherited retinal diseases. Pioneering #GeneTherapy offers new hope. Read more here: moorfieldsbrc.nihr.ac.uk/wp-content/u... Prof. Alison Hardcastle & Prof. James Bainbridge @ucleye.bsky.social
Alt text: "Banner for the NIHR Moorfields Biomedical Research Centre featuring the title 'Case study: Genomic Discovery and Therapeutics' and the main text 'Pioneering gene therapies to treat young people with inherited retinal diseases.' Includes a logo in the top left and a DNA strand icon with a green dot on the left side
013
Reposted by @hardcastlelab.bsky.social
Carlo Rivolta @carlorivolta.bsky.social · 25/05/2025
Congratulations Mathieu! @mquinodoz.bsky.social @iobswiss.bsky.social @erdc-team.bsky.social
052
Reposted by @hardcastlelab.bsky.social
The American Journal of Human Genetics @ajhgnews.bsky.social · 23/05/2025
It's true! If your submitted manuscript reports findings presented in your ASHG talk, we will send it out for peer review.
031
Reposted by @hardcastlelab.bsky.social
Elfride De Baere @elfridedebaere.bsky.social · 23/05/2025
🧬 HIghly recommended multidisciplinary, inspiring, cutting-edge top event of human genetics! 🧬 👇
011
Reposted by @hardcastlelab.bsky.social
Suzanne de Bruijn @suzannedebruijn.bsky.social · 23/04/2025
🚨New paper alert🚨 After 40+ years of diagnostic uncertainty, we cracked the case! rdcu.be/eiLAg In an individual with Senior-Løken syndrome, traditional tests failed to identify a genetic cause. By combining #OGM and #LRS, we uncovered a hidden intronic mobile element insertion in IQCB1 (1/2).
rdcu.be
Long-read technologies identify a hidden LINE-1/ERV1 insertion in IQCB1 as causative variant for Senior-Løken syndrome
npj Genomic Medicine - Long-read technologies identify a hidden LINE-1/ERV1 insertion in IQCB1 as causative variant for Senior-Løken syndrome
151
Reposted by @hardcastlelab.bsky.social
Edouard Machery @edouardmachery.bsky.social · 18/04/2025
the ERC has added a million euro for researchers moving to Europe.
sciencebusiness.net
ERC to double allowance for researchers moving to EU
The European Research Council (ERC) is doubling the relocation allowance it makes to researchers coming to the EU to take up one of its grants. At present it offers third-country researchers up to €1 ...
415176