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Mike Cheetham

@cheethamlab.bsky.social
85 followers 90 following 16 posts

Retinal cell biologist studying IRDs. Likes organoids, Alfa Romeo and Leeds United

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Reposted by Mike Cheetham
arvoiovs.bsky.social @arvoiovs.bsky.social · 03/08/2026
Susanne Roosing et al. from Radboud University Medical Center Identify a duplication in the RP17 locus in an individual with pathogenic CEP290 variants. doi.org/10.1167/iovs.67.10.1
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Matteo Carandini @carandinilab.net · 13/07/2026
My home institute, @ucleye.bsky.social, is looking for a new Director! www.veredus.co.uk/job/job-1183a/
veredus.co.uk
Director of the UCL Institute of Ophthalmology - REF 1183 | Veredus
University College London Director of the UCL Institute of Ophthalmology  Location: London Salary: An attractive remuneration package UCL is a world leading, global university with a community of more...
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Mike Cheetham @cheethamlab.bsky.social · 29/06/2026
Come and join us!
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Reposted by Mike Cheetham
UCL Institute of Ophthalmology @ucleye.bsky.social · 29/06/2026
We have two Research Fellow vacancies available to join @cheethamlab.bsky.social at @ucleye.bsky.social. The Research Fellows will explore molecular mechanisms of retinal degeneration and test potential therapeutic approaches. These positions close on 8 July. www.ucl.ac.uk/work-at-ucl/...
ucl.ac.uk
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
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Mike Cheetham @cheethamlab.bsky.social · 29/06/2026
Love vision and want to help cure disease? We have a vacancy tor a post-doc come and join our team! www.ucl.ac.uk/work-at-ucl/...
ucl.ac.uk
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
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themsblog.bsky.social @themsblog.bsky.social · 06/04/2026
New post: Prof Angray Kang End of an Era multiple-sclerosis-research.org/202…
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Tom Burgoyne Lab @tomburgoynelab.bsky.social · 30/03/2026
Our new paper is out today in @arvoiovs.bsky.social We provide evidence that the connecting cilium rootlet in mouse photoreceptors may act as a scaffold that supports ER positioning, enabling it to branch and form membrane contact sites with other cellular membranes. @ucleye.bsky.social
iovs.arvojournals.org
The P23H Rhodopsin Mouse Model Reveals a Novel Interaction Between the Endoplasmic Reticulum and Connecting Cilium Rootlet Within Photoreceptors | IOVS | ARVO Journals
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Reposted by Mike Cheetham
UCL Institute of Ophthalmology @ucleye.bsky.social · 19/02/2026
Research Assistant in Ocular Cell Biology position closes on 25 February. This would suit an ambitious graduate with a background in the mechanisms of repeat expansion biology, neurodegeneration, and human disease models. www.ucl.ac.uk/work-at-ucl/...
ucl.ac.uk
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
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Reposted by Mike Cheetham
UCL Institute of Ophthalmology @ucleye.bsky.social · 11/02/2026
Happy 200th birthday, UCL! Today marks 200 years since UCL was founded, London's very first university. We are very proud to be part of its rich and diverse community of scientists, students and researchers. #UCL200
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Mike Cheetham @cheethamlab.bsky.social · 18/09/2025
Classic cars near the Rudolfinum Prague #RD20205 @bwjones.bsky.social
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hardcastlelab.bsky.social @hardcastlelab.bsky.social · 17/09/2025
We’ll done Owen 👏 great talk at @rd2025.bsky.social in Prague
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hardcastlelab.bsky.social @hardcastlelab.bsky.social · 17/09/2025
Amazing science being presented @rd2025.bsky.social including from our team @ucleye.bsky.social 🧫🧬🧪🔬
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hardcastlelab.bsky.social @hardcastlelab.bsky.social · 17/09/2025
We’ll done Davide 👏 excellent talk @rd2025.bsky.social
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Adam Rutherford @adamrutherford.bsky.social · 14/08/2025
An absolute scam. Does this serve science? No it does not. www.thebookseller.com/news/springe...
thebookseller.com
Springer Nature's revenue increases to €926m as adjusted operating profit soars
Springer Nature's group revenue has risen by 6% to €926m (£800m) in the first half of 2025, while adjusted operating profit (AOP) was up by 10% to €241m (£208m).
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Reposted by Mike Cheetham
UCL Institute of Ophthalmology @ucleye.bsky.social · 22/07/2025
Everyone at @ucleye.bsky.social has been deeply saddened by the passing of a highly esteemed colleague in June 2025. www.ucl.ac.uk/news/2025/ju...
ucl.ac.uk
Tribute to eye treatment pioneer Professor Pete Coffey
UCL colleagues have paid tribute to world-leading eye researcher Professor Pete Coffey, who pioneered a treatment enabling people whose vision had been destroyed by disease to see again.
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Reposted by Mike Cheetham
hardcastlelab.bsky.social @hardcastlelab.bsky.social · 11/07/2025
Congratulations Freddie on your PhD defence 🎉🥳 huge thank to the examiners Chris Inglehearn and Dan Gore 🙏
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Amanda Carr @amandajcarr.bsky.social · 07/07/2025
It’s incredibly hard to express what Professor Pete Coffey meant to so many of us. The Macular Society has written a beautiful tribute to Pete and I'm honoured to have contributed a few words. Thank you, my friend, for so many happy days. www.macularsociety.org/about/media/...
macularsociety.org
Tributes paid to pioneering eye researcher Professor Pete Coffey
Tributes have been paid to one of the world’s top eye researchers, Professor Pete Coffey, who has sadly passed away after a long illness.
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UCL Institute of Ophthalmology @ucleye.bsky.social · 10/03/2025
Our Deputy Director Prof Alison Hardcastle @hardcastlelab.bsky.social, features in the video of the launch of a new Centre of Excellence for eye health in Warsaw: a partnership between @ucleye.bsky.social, ICTER, and the Institut de la Vision at Université Sorbonne. www.ucl.ac.uk/ioo/news/202...
ucl.ac.uk
IoO represented at launch of Poland's new teaming project
The official ceremony launched three new Teaming for Excellence projects funded by the European Union under the Horizon Europe framework programme for research and innovation.
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Reposted by Mike Cheetham
hardcastlelab.bsky.social @hardcastlelab.bsky.social · 06/03/2025
Now in print and open access. Thanks @ajhgnews.bsky.social for feature in Editors Corner 🧪🧫🧬
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Julio Corral-Serrano @jcorralserrano.bsky.social · 03/03/2025
I'm very proud and happy to share our work of many (many!) years, on a novel ARL3-G70E variant, linked to IRD. 🎉 📖 Read the full paper here: academic.oup.com/hmg/advance-... #ARL3 #retina #cilia #RPE #organoids 🧵
academic.oup.com
A novel recurrent ARL3 variant c.209G > A p.(Gly70Glu) causes variable non-syndromic dominant retinal dystrophy with defective lipidated protein transport in human retinal stem cell models
Abstract. Inherited retinal dystrophies (IRDs) are characterized by their high clinical and genetic heterogeneity. Despite significant advances in the iden
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Julio Corral-Serrano @jcorralserrano.bsky.social · 03/03/2025
🧪 We modelled this variant for the first time using human stem cell derived RPE and retinal organoids, showing ciliary trafficking defects that are not present in other cell types (like skin fibroblasts).
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Elfride De Baere @elfridedebaere.bsky.social · 03/03/2025
Big thank you 🙏 to Julio Corral-Serrano @cheethamlab.bsky.social @carlorivolta.bsky.social @hardcastlelab.bsky.social @elfridedebaere.bsky.social & many colleagues. Funded by @moorfieldsbrc.bsky.social @wellcometrust.bsky.social ‪@iobswiss.bsky.social‬ @ugent-fge.bsky.social JTC EJPRD Solve-RET FWO
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Mike Cheetham @cheethamlab.bsky.social · 03/03/2025
And @hardcastlelab.bsky.social supported by @moorfieldsbrc.bsky.social @wellcometrust.bsky.social and many others
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Mike Cheetham @cheethamlab.bsky.social · 03/03/2025
And @hardcastlelab.bsky.social supported by @moorfieldsbrc.bsky.social @wellcometrust.bsky.social and many others
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Mike Cheetham @cheethamlab.bsky.social · 03/03/2025
Delighted to be part of this study led by Julio Corral-Serrano with @elfridedebaere.bsky.social and @carlorivolta.bsky.social
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Mike Cheetham @cheethamlab.bsky.social · 03/03/2025
academic.oup.com/hmg/advance-...
academic.oup.com
A novel recurrent ARL3 variant c.209G > A p.(Gly70Glu) causes variable non-syndromic dominant retinal dystrophy with defective lipidated protein transport in human retinal stem cell models
Abstract. Inherited retinal dystrophies (IRDs) are characterized by their high clinical and genetic heterogeneity. Despite significant advances in the iden
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Reposted by Mike Cheetham
NIHR Biomedical Research Centre: Moorfields @moorfieldsbrc.bsky.social · 28/02/2025
This #RareDiseaseDay join our #Research Roadshow at Moorfields! Today: 14:00 - 16:00 @ Opposite Costa - Moorfields Cheetham lab: Discover how genes can both cause problems and offer solutions. #RetinitisPigmentosa #LeberCongenitalAmaurosis & #DominantOpticAtrophy @moorfieldsfriends.bsky.social
Two women stand next to a scientific poster on inherited blindness and treatment research, smiling at the camera. One wears a green sweater with a lanyard and ID badge, while the other wears a blue striped shirt. A banner for Moorfields Biomedical Research Centre is visible to the right, and the setting appears to be a research or healthcare facility.
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Reposted by Mike Cheetham
hardcastlelab.bsky.social @hardcastlelab.bsky.social · 21/02/2025
www.bbc.co.uk/news/article...
bbc.co.uk
Gene therapy experiment treats rare childhood blindness - BBC News
Four toddlers born with a rare eye condition have seen "life-changing improvements", say UK doctors.
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hardcastlelab.bsky.social @hardcastlelab.bsky.social · 21/02/2025
Amazing results of gene therapy in very young children from @ucleye.bsky.social 👏👏 www.thelancet.com/journals/lan...
thelancet.com
Gene therapy in children with AIPL1-associated severe retinal dystrophy: an open-label, first-in-human interventional study
Our findings indicate that young children with AIPL1-related retinal dystrophy benefited substantially from subretinal administration of rAAV8.hRKp.AIPL1, with improved visual acuity and functional vi...
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Mike Cheetham @cheethamlab.bsky.social · 13/02/2025
Thanks to @moorfieldsbrc.bsky.social Moorfields Eye Charity @wellcometrust.bsky.social @fightblindness.bsky.social Fight for Sight amongst others for support.
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Mike Cheetham @cheethamlab.bsky.social · 13/02/2025
actaneurocomms.biomedcentral.com/articles/10.... Delighted to share a paper from Michael Whitehead and the rest of the team on OPA1 mediated dominant optic atrophy.
actaneurocomms.biomedcentral.com
Disruption of mitochondrial homeostasis and permeability transition pore opening in OPA1 iPSC-derived retinal ganglion cells - Acta Neuropathologica Communications
Dominant optic atrophy (DOA) is the most common inherited optic neuropathy, characterised by the selective loss of retinal ganglion cells (RGCs). Over 60% of DOA cases are caused by pathogenic variant...
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Mike Cheetham @cheethamlab.bsky.social · 12/02/2025
Thanks to @fightblindness.bsky.social @wellcometrust.bsky.social and @moorfieldsbrc.bsky.social for support amongst others and all the staff @ucleye.bsky.social
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Mike Cheetham @cheethamlab.bsky.social · 12/02/2025
Delighted to share our new publication on modelling childhood blindness in retinal organoids and rescue of some of the phenotypes with small molecules great work by Dimitra Athanasiou and the team actaneurocomms.biomedcentral.com/articles/10....
actaneurocomms.biomedcentral.com
Small molecule treatment alleviates photoreceptor cilia defects in LCA5-deficient human retinal organoids - Acta Neuropathologica Communications
Bialleleic pathogenic variants in LCA5 cause one of the most severe forms of Leber congenital amaurosis, an early-onset retinal disease that results in severe visual impairment. Here, we report the us...
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NIHR Biomedical Research Centre: Moorfields @moorfieldsbrc.bsky.social · 07/02/2025
A study in @ajhgnews.bsky.social has discovered a genetic cause of a rare eye condition called X-linked inherited retinal dystrophy. Innovation solved a ten-year mystery across three generations. 🔗 buff.ly/42IS7pD Audio description: buff.ly/4gxivWK hardcastlelab.bsky.social‬ @ucleye.bsky.social
An infographic titled 'Research Simplified' showcases four significant advances in retinal research with icons for visual emphasis:

A target icon denotes 'Genetic cause of rare inherited retinal dystrophy discovered.'
An eye icon represents 'Stem cell technology and lab-grown retinas reveal genetic clues.'
A DNA strand icon highlights 'Jumping chromosomes disrupt how genes work.'
A handshake icon symbolizes 'Paving the way for earlier diagnosis.'
The footer features the NIHR Moorfields Biomedical Research Centre logo.
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Elfride De Baere @elfridedebaere.bsky.social · 03/02/2025
📣 Very important paper alert! 📣 Exciting study highlighting complex interchromosomal insertions in human (X-linked retinal) disease and a wide variety of patient-derived models to study transcriptional and epigenomic effects. Congrats to @hardcastlelab.bsky.social @cheethamlab.bsky.social et al. 👏👏👏
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The American Journal of Human Genetics @ajhgnews.bsky.social · 31/01/2025
📣New from Gardner et al. 📄Inter-chromosomal insertions at Xq27.1 associated with retinal dystrophy induce dysregulation of LINC00632 and CDR1as/ciRS-7
cell.com
Inter-chromosomal insertions at Xq27.1 associated with retinal dystrophy induce dysregulation of LINC00632 and CDR1as/ciRS-7
Inter-chromosomal insertions within a palindrome on Xq27 are associated with rare X-linked diseases, but how they cause disease is unknown. We describe two retinal dystrophy families with different in...
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Mike Cheetham @cheethamlab.bsky.social · 31/01/2025
Great story from @hardcastlelab.bsky.social lab with Jessica Gardner. Proud to have been able to help.
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NIHR Biomedical Research Centre: Moorfields @moorfieldsbrc.bsky.social · 31/01/2025
Our colleagues presented at the Festival of Genomics & Biodata! Dr Alice Davidson shared her lab’s work on the genetics of inherited corneal disease to improve diagnosis & treatment. Dr Nikolas Pontikos & Eye2Gene are using #AI to speed up inherited retinal disease detection. @ucleye.bsky.social
Alice Davidson stands at a podium speaking at the Festival of Genomics & Biodata in London, with a large event backdrop displaying sponsors and the festival logo in the backgroundNikolas Pontikos presents on genetic eye diseases at the Festival of Genomics & Biodata in London, with a slide stating global statistics on blindness due to genetic eye conditions.
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Mike Cheetham @cheethamlab.bsky.social · 25/01/2025
Apologies for the photo - long way off but got a better look with binoculars. Possible as some trans located to where we were www.birdguides.com/articles/orn...
birdguides.com
Translocated hawks thrive in Hispaniola
A new study has revealed how the translocation of Critically Endangered Ridgway's Hawks is proving a success in the species' conservation.
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Mike Cheetham @cheethamlab.bsky.social · 25/01/2025
@tmr65.bsky.social what do you think?
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hardcastlelab.bsky.social @hardcastlelab.bsky.social · 10/01/2025
Check out this v interesting preprint. RNU variants associated with RP. Components of spliceosome are fascinating www.medrxiv.org/content/10.1...
medrxiv.org
De novo and inherited dominant variants in U4 and U6 snRNAs cause retinitis pigmentosa
The U4 small nuclear RNA (snRNA) forms a duplex with the U6 snRNA and, together with U5 and ∼30 proteins, is part of the U4/U6.U5 tri-snRNP complex, located at the core of the major spliceosome. Recen...
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hardcastlelab.bsky.social @hardcastlelab.bsky.social · 04/12/2024
Christmas season cheer SPARCL1 gene 💍 implicated in corneal dystrophy in EJHG Dec issue www.nature.com/articles/s41...
nature.com
Autosomal dominant stromal corneal dystrophy associated with a SPARCL1 missense variant - European Journal of Human Genetics
European Journal of Human Genetics - Autosomal dominant stromal corneal dystrophy associated with a SPARCL1 missense variant
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MouseDoctor @mousedoctor.bsky.social · 30/11/2024
pubmed.ncbi.nlm.nih.gov/39611149/ B cell Research Outputs. ProfB No. 5 in the World. Not Bad Considering Not a Single Penny of Grant Income. #QMUL in top ten with 3/Top 10 Scientists
pubmed.ncbi.nlm.nih.gov
Global perspectives on the contribution of B cells to multiple sclerosis: an in-depth examination and evaluation - PubMed
This bibliometric analysis highlights pivotal research trends, key contributors, and emerging areas of interest in B cell research in MS from 2013 to 2024. The findings underscore the growing recognit...
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John Crace @mrjohncrace.bsky.social · 13/11/2024
Hello everyone. I am now on this platform for social media. Do please repost this message so that more people can find me!
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