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Niko Fleischer

@hal4k.bsky.social
105 followers 201 following 18 posts

Grad student with @ruth_stassart and @rfledrich @Paul-Flechsig-Institut Leipzig. Neuropathology, peripheral nerves, Schwann cells, Axon-Glia interactions from bed to bench to count matrix. single-cell tx | spatial tx | image analysis | stats | data viz

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Niko Fleischer @hal4k.bsky.social · 25/09/2026
😱
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Emily M. Bender @emilymbender.bsky.social · 13/09/2026
Straight talk time: Doomerism is BORING. It's the same fantasties rehashed over and over again, just louder each time. And with each iteration it seems that new audiences are being reached, and a new group of people needs to be talked down from unnecessary fear. >>
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Nick Stroustrup @nstroustrup.bsky.social · 05/09/2026
Did you know that the cells of old animals contain much less mRNA than the cells of young ones? Let me share with you some results from an ongoing project in the lab, where we are finding that a progressive depletion of total mRNA abundance is a crucial part of aging 1/22
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Solomon Kurz @solomonkurz.bsky.social · 27/05/2026
Part of the issue is the world doesn’t owe you an answer just because you have an interesting question, and I suspect many of our interesting social science questions will go unanswered for a very long time.
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Joachim Goedhart @joachimgoedhart.bsky.social · 22/05/2026
Awesome idea, bridging Excel with ggplot2 ⬇️ Figra: A WebAssembly-based Excel Add-in for publication-quality scientific visualization with ggplot2 by Yoshiaki Sato: www.biorxiv.org/content/10.6...
biorxiv.org
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Boxo McFoxo @boxobark.ing · 20/04/2026
As a predominantly inattentive ADHDer, the only way that an LLM could 'help' me write is with cognitive offloading, which is actually a lie, and one that I do not trust. For grammar checking, there is a great open source alternative to Grammarly which is entirely non-LLM called Harper.
writewithharper.com
Harper | Privacy-First Offline Grammar Checker
Harper checks your writing instantly—fast, lightweight and utterly private—so you can polish every clause without surrendering a single keystroke.
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Gonçalo Castelo-Branco @gocastelobranco.bsky.social · 19/03/2026
Our latest in @natneuro.nature.com, lead by Mukund Kabbe, providing single cell epigenomic maps of the human brain and spinal cord with snATAC and our NanoCUT&Tag and finding epigenetic memory in oligodendroglia of developmental programs! www.nature.com/articles/s41...
nature.com
Single-nucleus epigenomic profiling of the adult human central nervous system unveils epigenetic memory of developmental programs - Nature Neuroscience
Single-nucleus epigenomic maps of the adult human brain and spinal cord reveal that adult oligodendroglia retain developmental chromatin patterns, suggesting a molecular memory that may shape repair p...
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Darren Dahly @statsepi.bsky.social · 18/03/2026
Every day is a good day for sharing one of the most useful papers about research data ever written. PLEASE get your people to understand and follow this advice. www.tandfonline.com/doi/full/10....
Data Organization in Spreadsheets
Karl W. Broman
& Kara H. Woo
Pages 2-10 | Received 01 Jun 2017, Accepted author version posted online: 29 Sep 2017, Published online: 24 Apr 2018

    1. Introduction
    2. Be Consistent
    3. Choose Good Names for Things
    4. Write Dates as YYYY-MM-DD
    5. No Empty Cells
    6. Put Just One Thing in a Cell
    7. Make it a Rectangle
    8. Create a Data Dictionary
    9. No Calculations in the Raw Data Files
    10. Do Not Use Font Color or Highlighting as Data
    11. Make Backups
    12. Use Data Validation to Avoid Errors
    13. Save the Data in Plain Text Files

ABSTRACT

Spreadsheets are widely used software tools for data entry, storage, analysis, and visualization. Focusing on the data entry and storage aspects, this article offers practical recommendations for organizing spreadsheet data to reduce errors and ease later analyses. The basic principles are: be consistent, write dates like YYYY-MM-DD, do not leave any cells empty, put just one thing in a cell, organize the data as a single rectangle (with subjects as rows and variables as columns, and with a single header row), create a data dictionary, do not include calculations in the raw data files, do not use font color or highlighting as data, choose good names for things, make backups, use data validation to avoid data entry errors, and save the data in plain text files.
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Lior Pachter @lpachter.bsky.social · 06/03/2026
kallisto sped up RNA-seq quantification by 50x. Now another 50x speedup... quantify hundreds of millions of reads in a few seconds. This seems too good to be true. But it's true! Incredible accomplishment by @pmelsted.bsky.social.
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Nicholas Mancuso @nmancuso.bsky.social · 06/05/2025
Errors. Call them errors ffs. They're not hallucinations they're not lies. Call them errors. This dumbass personification of a fancy prediction tool is only reinforcing the idea that these things really are intelligent and not just a computer program.
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A*STAR Genome Institute of Singapore (A*STAR GIS) @astar-gis.bsky.social · 21/03/2025
Congratulations to @jonathangoeke.bsky.social, and our @astar-gis.bsky.social team on your SG-NEx project, providing a comprehensive resource that enables the development and benchmarking of computational methods for profiling complex transcriptional events at isoform-level resolution.
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