Genetic load is often overlooked in conservation predictions of species response to climate change. This study found that effective population size was the major determinant of genetic load and that g...

Vacancy at Center for Quantitative Genetics and Genomics, Aarhus University

Vacancy at Center for Quantitative Genetics and Genomics, Aarhus University

Transposable elements (TEs) are ubiquitous components of the genome whose mobility can be triggered by environmental stress and influenced by genotype…

Genome-wide association studies have revealed that the genetic architectures of complex traits vary widely. This study shows that differences in architectures of highly polygenic traits arise mainly f...

Key message Sequence-based AI models show great potential for prediction of variant effects at high resolution, but their practical value in plant breeding remains to be confirmed through rigorous val...

Nature Reviews Genetics - Multiplexed assays of variant effect (MAVEs) are highly scalable experimental approaches used to generate functional data for genetic variants. In this Review, McEwen et...

Background The emergence of genomic language models (gLMs) offers an unsupervised approach to learning a wide diversity of cis-regulatory patterns in the non-coding genome without requiring labels of ...

In controlled greenhouse conditions, Arabidopsis thaliana plants with a hyperactive allele of the ACD6 gene have stronger pathogen defenses but are smaller and make fewer seeds, in a classic fitness t...

A study describes the assembly and analysis of a haplotype-resolved pangenome of bulbous barley with the potential to improve domesticated barley and illustrates its use in evolutionary research and trait mapping.

Ledig stilling ved Center for Kvantitativ Genetik og Genomforskning, Aarhus, Aarhus Universitet

Gene duplication and subsequent paralogue diversification are major obstacles to genotype-to-phenotype predictability.

In this paper, we introduce ``UniLasso'' -- a novel statistical method for sparse regression. This two-stage approach preserves the signs of the univariate coefficients and leverages their magnitude. ...

Vacancy at Center for Quantitative Genetics and Genomics - Quantitative Gen. and Genomics, Flakkeberg, Aarhus University

A PhD fellowship in Evolutionary Biology is being posted in the research team lead by Assistant Prof Jazmín Ramos Madrigal commencing 1 July 2025 or as soon as

Over the last 20 million years, the Andropogoneae tribe of grasses has evolved to dominate 17% of global land area. Domestication of these grasses in the last 10,000 years has yielded our most product...

Grasses are fundamental to human survival, providing a large percentage of our calories, fuel, and fodder for livestock, and an enormous global carbon sink. A particularly important part of the grass...

A deleterious mutation in the tomato transcription factor SSP2 was enriched during domestication. Repairing the deleterious mutation in cultivated tomato by base editing leads to compact growth and ea...

A language model predicts the effects of genetic variants in the human genome.

Associate Professor / Professor of Evolutionary Genomics in the Department of Genetics at the University of Cambridge.

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Heredity - Multi-population GWAS detects robust marker associations in a newly established six-rowed winter barley breeding program

We seek an engaged, innovative, and visionary leader and accomplished scientist to catalyze new initiatives and collaborations, identify strategic priorities, and provide leadership in research, schol...

Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

Single-nucleus RNA-sequencing and chromatin-accessibility analyses in rice (a C3 plant) and sorghum (a C4 plant) provide insight into how C4 photosynthesis evolved in bundle-sheath cells, revealing th...

Population genetics notes. Contribute to cooplab/popgen-notes development by creating an account on GitHub.