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Anton Goloborodko

@golobor.bsky.social
1.8K followers 1.3K following 333 posts

A bio-physicist turned phys-biologist, building models and software in genome biology. 3D genome structure in mitosis | DNA repair | meiosis. A group leader at @IMBA_Vienna. Dad x2.

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Reposted by Anton Goloborodko
Ben Collins @bencollins.bsky.social · 13/10/2026
It does appear the "data center eliminated Nazi and otherwise fuckface bots" narrative is basically wishcasting, it does show you how popular getting rid of this shit would broadly be, and that maybe a smart person should run on it.
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Oregon 🕎🎲 @oregonthedm.bsky.social · 11/10/2026
The most fun thing ever to randomly see
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Jonas Holm Jæger @jonasholmjaeger.bsky.social · 10/10/2026
Check it, nerds. Recent find of late stage Maglemosian (8400 BP) antler axe with preserved wooden handle from Egholm, Northern Jutland. Fantastic to see that we still have conditions in Denmark for such fantastic organic preservation. Because it probably won’t be long before we don’t.
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Alex de Mendoza @alexdemendoza.bsky.social · 06/10/2026
It's live! The next @embo.org #EvoChromo meeting will take place next year October in St Feliu de Guíxols (Spain), check it out here: meetings.embo.org/event/27-chr.... It's been great to co-organise with @dodonova-sveta.bsky.social @kellervalsecchi.bsky.social @cedricfeschotte.bsky.social & Nick I.
meetings.embo.org
Chromatin evolution from molecules to genomes
Technological advances over the past decade have enabled genome-wide mapping of chromatin organization across diverse organisms at unprecedented resolution. These studies have uncovered both conserve…
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Reposted by Anton Goloborodko
Elif Karagöz @gekaragoz.bsky.social · 09/10/2026
We’re recruiting postdocs! Join our Emerging Fields consortium to explore ribosome biology and translational control in pediatric cancers. My lab combines high-resolution Ribo-seq with unbiased genetic screens to uncover novel regulatory mechanisms. Deadline: 15 Nov 2026 lnkd.in/dmKJ7zbb
lnkd.in
LinkedIn
This link will take you to a page that’s not on LinkedIn
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Ann T. Tate @annttate.bsky.social · 09/10/2026
Please RT: Do you use math to address interesting biological problems? Join us at Vanderbilt BioSci! We are conducting an open-rank TT search in Theoretical Biology: apply.interfolio.com/194619. We are a friendly and collaborative department with interests spanning a range of biological disciplines!
apply.interfolio.com
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
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Universität Wien / University of Vienna @univie.ac.at · 09/10/2026
Why are octopuses, squid & cuttlefish so smart? 🐙 New study from the University of Vienna: it’s not just the genes, but how the genome folds in 3D. An ancient reorganisation brought distant #DNA regions together and rewired gene regulation. 🧬#Genomics Out now in @natcomms.nature.com ⤵️
univie.ac.at
3D structure of DNA may explain how cephalopods evolved complex brains
Study suggests that the 3D "entanglement" of DNA may help drive evolutionary innovation
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Matthew Freeman @mjafreeman.bsky.social · 30/09/2026
Yet another opportunity @dunnschool.bsky.social! We are looking for an Associate Professor If you have exciting research plans, @dunnschool.bsky.social is a great place: excellent science (and lovely people, obvs) www.path.ox.ac.uk/vacancy/asso...
path.ox.ac.uk
Associate Professorship of Cancer Biology - Sir William Dunn School of Pathology in association with the Queen’s College. - Dunn School
We are seeking to appoint an Associate Professor working in the area of the cellular and/or molecular biology of cancer, to be based in Oxford University’s Sir William Dunn School of Pathology. The ro...
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Rajiv McCoy @rajivmccoy.bsky.social · 08/10/2026
Johns Hopkins Biology is hiring a tenure-track Assistant Professor in computational genetics and genomics. Applications due Nov. 8th: apply.interfolio.com/194924 In my experience, this has been an incredibly supportive environment to build a lab. Please feel free to reach out with any questions.
apply.interfolio.com
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
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Plaschka lab @plaschkalab.bsky.social · 08/10/2026
After excising an intron, the spliceosome gets trapped on the branched intron-lariat RNA. How are such dead-end spliceosomes terminated? Our latest paper led by @vytaute.bsky.social investigates the mechanism of spliceosome termination www.nature.com/articles/s41... (1/6)
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Ben Collins @bencollins.bsky.social · 05/10/2026
jail
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Anton Goloborodko @golobor.bsky.social · 03/10/2026
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Anton Goloborodko @golobor.bsky.social · 03/10/2026
A corporation that believes that AI is conscious AND is powerful enough to destroy human civilization AND pushes full steam ahead with its development would've fit great into the Fallout universe
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Victor Tatarskiy @greenrat.bsky.social · 30/09/2026
Wait, what??? I think a lot of nerds in Russia are familiar with Eskov's book, but I always thought that a) nobody outside of Ru knows it b) Eskov writing was a bit tongue in chick, "look guys how clever I am" (compared to the "Black Book of Arda" which is more "serious" in tone
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Randall Munroe @xkcd.com · 02/10/2026
Ground Effect xkcd.com/3305/
Comic. [Two people flailing high in the air. Three people on the ground running ahead of them. Arrows and a dotted line indicate that this second group is within roughly one body length of the surface.] [caption] The “ground effect” explains why sprinters can run most efficiently if they stay within roughly one body length of the surface.
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Anton Goloborodko @golobor.bsky.social · 01/10/2026
...yet another illustration why explicit, thoughtful modeling is still worth the time, as compared to using heuristics #methodsmatter
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Reposted by Anton Goloborodko
Nina Willburger @drnwillburger.bsky.social · 01/10/2026
Fishing some 5,300 years ago: a Neolithic fishhook made of a wild boar tusk, wrapped with a fishing line. The size of the fishhook is 6.5 cm. It was used to catch pikes. Found in the lake-dwelling settlement of Arbon Bleiche 3, Switzerland. On display at Archäologisches Museum Frauenfeld 📷me 🏺
The picture shows a fishhook made of wild boar tusk. Only the curved, pointed end and the upper part are visible. The rest is wrapped in fishing line. The fishing line is made of twisted bast.
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Markus Sulzbacher @msulzbacher.bsky.social · 30/09/2026
Die Stadt Wien ist Opfer einer Cyberattacke geworden. Unbekannte verschafften sich Zugriff auf die EDV und stahlen rund 26.000 interne Dokumente. Darunter befinden sich Daten von 6.000 Personen. Hinweise, dass sie veröffentlicht wurden, gibt es nicht. wien.orf.at/stories/3373...
wien.orf.at
Cyberangriff auf Stadt Wien
Die Stadt Wien ist Opfer einer Cyberattacke geworden. Unbekannte verschafften sich Zugriff auf die EDV und stahlen rund 26.000 interne Dokumente. Darunter befinden sich Daten von 6.000 Personen. Hinw...
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 29/09/2026
For the last 34 years I have been on the faculty of the UNC-Chapel Hill Department of Biology and have never regretted that decision. This year we are hiring TWO new Assistant Professors in the broad area of Molecular, Cell, Developmental Biology 1/n bio.unc.edu
Front page of the website
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Anton Goloborodko @golobor.bsky.social · 27/09/2026
This sentence assumes that condensed==inaccessible - is that established actually? It's not the first/only paper doing that, ofc, but what evidence supports this assumption?
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Anton Goloborodko @golobor.bsky.social · 27/09/2026
TIL 186 existed! (we started with ZX spectrum and then a 286) Makes sense, in retrospect.
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Anton Goloborodko @golobor.bsky.social · 27/09/2026
The only one I didn't play is sopwith!
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Anton Goloborodko @golobor.bsky.social · 26/09/2026
Also, how could i forget fallout 2!
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Anton Goloborodko @golobor.bsky.social · 26/09/2026
This was a great exercise in memory excavation. The top 5-ish ones I played when I was 7-8, so I recall little substance (single frames at most), but they bring out strong emotions
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Anton Goloborodko @golobor.bsky.social · 26/09/2026
could be! www.coreweave.com/pricing/clas... - A100 (2020-2021) is $2/hour (= $48/day = $15K/year at full utilization), so it's still making them good money. Also, all datacenter companies keep saying that they have more demand than they can supply. They are motivated to say that ofc, but...
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Anton Goloborodko @golobor.bsky.social · 25/09/2026
FLOP/watt is much worse though, indeed!
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Anton Goloborodko @golobor.bsky.social · 25/09/2026
5 years is way too conservative, though. The RTX 6000/A100s in our HPC cluster are still going strong and remain very useful after 6 years, and will probably stay in use for quite a while.
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Anton Goloborodko @golobor.bsky.social · 25/09/2026
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Institute of Molecular Biotechnology @imbavienna.bsky.social · 12/08/2026
We are hiring! Join the de Groot Lab as a Master's Student / Research Intern in Computational Biology and Theoretical Modeling to develop a Bayesian method for comparing single-cell datasets by explicitly modeling measurement noise to bring out true biological variability.
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Adam Rogers @jetjocko.bsky.social · 23/09/2026
Privatize the gains and socialize the apocalypse.
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Anton Goloborodko @golobor.bsky.social · 24/09/2026
congratulations, Maya!!!
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Maya Voichek @mayavoichek.bsky.social · 24/09/2026
Super excited to share my postdoctoral work at @imbavienna.bsky.social @viennabiocenter.bsky.social - We discovered that some retrotransposons, or "jumping genes" 🧬, are able to spread from cell to cell via a new viral infectivity route. A short thread: 🧵👇 (1/7)
AI-generated illustration of the soma-to-germline transmission of retrotransposons described in our work
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Richard Sever @richardsever.bsky.social · 21/09/2026
It's also worth reading the postscript about Bsky. Some won't agree, but after fleeing the unpleasantness of what twitter became, this community should be concerned it's created an echo chamber in which any departure from a line is attacked (reasonable discussion =/ tolerating bigotry/misinfo).
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Joshua G. Schraiber @jgschraiber.bsky.social · 20/09/2026
This is definitely what people don't realize I think. Where AI is *right now* is way way way better than you think. It's way better than even the biggest proponents think. And it's clearly still getting better
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S.E. Danesti @seedanesti.bsky.social · 19/09/2026
Interviewer: "Where do you see yourself in 5 years?" Me:
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Nezar Abdennur @nvictus.bsky.social · 19/09/2026
The 4DN Center for 3D Structure and Physics of the Genome proudly presents: "Stepwise reorganization of chromosome conformation and nuclear organization during stem cell differentiation". www.biorxiv.org/content/10.6...
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Aurele Piazza @aurelepiazza.bsky.social · 18/09/2026
What molecular mechanisms underlie the needle-in-a-haystack search for homology required to fix a DNA break? In this preprint, we reveal multiple controls of homology search in cells: onset, coordination, reach and inactivation. www.biorxiv.org/content/10.6...
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Anton Goloborodko @golobor.bsky.social · 18/09/2026
How come there's so little chat about *that*?.. the more I think about the scenario of devastating AI-augmented/driven wars or runaway military AI, the more my subjective P(doom) tends to 1.0. Am I missing some counter-factor? 4/4
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Anton Goloborodko @golobor.bsky.social · 18/09/2026
Furthermore, the current AI "leadership" doesn't seem to worry about these applications and, if anything, (in)directly encourages them through increased discussions of geopolitical competition and sovereignty 3/
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Anton Goloborodko @golobor.bsky.social · 18/09/2026
War is ugly and, as I understand, every possible technical solution gets explored. War and oppression would benefit the most from centralized coordination and autonomous decision making. AI will be trained to hunt and kill people and do it with less and less oversight. 2/
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Anton Goloborodko @golobor.bsky.social · 18/09/2026
With all the chatter on unintended AI misalignment, I worry much more about intended misalignment, namely, in military and law enforcement. 1/
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conputer dipshit @davidcrespo.bsky.social · 02/08/2026
exactly, “gen AI” just means “bad AI” in order to avoid the charge of being against *all* AI. I am also against bad AI. by defintion, everyone is against bad AI!
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sephirAmy @sephiramy.bsky.social · 17/09/2026
how about some good news: new cat just dropped!!!!
a photo of a small, spotted wild cat, with orange fur and brown circular markings, staring up with big golden eyes.Meet the First New Cat Species Discovered in 100 Years

A small, spotted tiger cat from Bolivia may just be the beginning of a wave of new small cat species.

This 10-year-old male tiger cat is the first of his species (named Leopardus tilcayo) known to science. He is approximately 18 inches from head to end of body and weighs only 3 pounds, making him smaller than the average domestic cat. This video was captured at the Senda Verde Animal Refuge in Bolivia’s Yungas region, where he currently resides.
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Lopes_Lab @lopeslab.bsky.social · 16/09/2026
Thrilled to share a new important study from the lab, published today in @nature.com, showing how cohesin mediates efficient replication fork plasticity and stress response, using its loop extrusion activity to promote 3D contacts on replicating DNA: www.nature.com/articles/s41...
nature.com
Cohesin reshapes replication fork contacts to aid fork slowing and reversal - Nature
Cohesin-mediated loop extrusion limits sister-fork coupling and tethers nearby replication forks under replication stress, promoting fork reversal and slowing fork progression to safeguard genome...
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Sergey Ovchinnikov @sokrypton.org · 17/09/2026
Introducing highly experimental localfold.org Building on @martinsteinegger.bsky.social af2 webgpu port, @milot.bsky.social optimizations & jax ports of af3-like models by @marielle.bsky.social, Choonghwan Lee, Julia Buhmann. WARNING: runs directly on your 💻, may drain 🪫 & eat data📱 & overheat 🔥💻
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Jens Schmidt @jenscs83.bsky.social · 15/09/2026
We are recruiting a postdoctoral fellow to study DNA damage repair via the homologous recombination pathway using quantitative cell biology approaches. The position will be initially supported for two years by the MSU Research Foundation Postdoctoral Scholars program. Please share! 1/5
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IMP @impvienna.bsky.social · 15/09/2026
Exciting news! We're thrilled to announce the six outstanding laureates of the International Birnstiel Award for Doctoral Studies in Molecular Life Sciences 2026! 🏆Congratulations to all awardees and honourable mentions! 🎉 1/ ➡️ www.imp.ac.at/news/article...
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Vijay Ramani @vram142.bsky.social · 14/09/2026
Everything you wanted to know about single-molecule epigenomics but were too afraid to ask! Wonderful to co-write (h/t ENORMOUS lift by @arnaudkr.bsky.social) this primer on our nascent field. Also, a 💯 example of wonderful colleagues building something *together*, not in competition =)
nature.com
A practical guide to studying genome function using single-molecule genomics
Nature Reviews Molecular Cell Biology - Single-molecule genomics methods are used to study the activity of regulatory factors on individual DNA molecules genome-wide, thereby enabling...
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Fena Ochs @fenaochs.bsky.social · 10/09/2026
My lab at the Center for Gene Expression (CGEN), University of Copenhagen is looking for a motivated Postdoc interested in cohesin biology, 3D chromatin, and super-resolution microscopy. 📩 Please email your CV and letter of intent to fena.ochs(at)sund.ku.dk.
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Anton Goloborodko @golobor.bsky.social · 10/09/2026
Personally, I am *very* excited about this development, as it paves the way for a new generation of scalable, robust, and easy-to-implement coarse-grained models of biological systems and also helps our lab enter this field. Please, let us know if you have any qs/comments/suggestions/future ideas!
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