Reposted by Anton GoloborodkoBen Collins @bencollins.bsky.social · 13/10/2026It does appear the "data center eliminated Nazi and otherwise fuckface bots" narrative is basically wishcasting, it does show you how popular getting rid of this shit would broadly be, and that maybe a smart person should run on it. 824349761
Reposted by Anton GoloborodkoOregon 🕎🎲 @oregonthedm.bsky.social · 11/10/2026The most fun thing ever to randomly see 111187733586
Reposted by Anton GoloborodkoJonas Holm Jæger @jonasholmjaeger.bsky.social · 10/10/2026Check it, nerds. Recent find of late stage Maglemosian (8400 BP) antler axe with preserved wooden handle from Egholm, Northern Jutland. Fantastic to see that we still have conditions in Denmark for such fantastic organic preservation. Because it probably won’t be long before we don’t. 2380109
Reposted by Anton GoloborodkoAlex de Mendoza @alexdemendoza.bsky.social · 06/10/2026It's live! The next @embo.org #EvoChromo meeting will take place next year October in St Feliu de Guíxols (Spain), check it out here: meetings.embo.org/event/27-chr.... It's been great to co-organise with @dodonova-sveta.bsky.social @kellervalsecchi.bsky.social @cedricfeschotte.bsky.social & Nick I.meetings.embo.orgChromatin evolution from molecules to genomesTechnological advances over the past decade have enabled genome-wide mapping of chromatin organization across diverse organisms at unprecedented resolution. These studies have uncovered both conserve… 03824
Reposted by Anton GoloborodkoElif Karagöz @gekaragoz.bsky.social · 09/10/2026We’re recruiting postdocs! Join our Emerging Fields consortium to explore ribosome biology and translational control in pediatric cancers. My lab combines high-resolution Ribo-seq with unbiased genetic screens to uncover novel regulatory mechanisms. Deadline: 15 Nov 2026 lnkd.in/dmKJ7zbblnkd.inLinkedInThis link will take you to a page that’s not on LinkedIn 01612
Reposted by Anton GoloborodkoAnn T. Tate @annttate.bsky.social · 09/10/2026Please RT: Do you use math to address interesting biological problems? Join us at Vanderbilt BioSci! We are conducting an open-rank TT search in Theoretical Biology: apply.interfolio.com/194619. We are a friendly and collaborative department with interests spanning a range of biological disciplines!apply.interfolio.com Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio 04558
Reposted by Anton GoloborodkoUniversität Wien / University of Vienna @univie.ac.at · 09/10/2026Why are octopuses, squid & cuttlefish so smart? 🐙 New study from the University of Vienna: it’s not just the genes, but how the genome folds in 3D. An ancient reorganisation brought distant #DNA regions together and rewired gene regulation. 🧬#Genomics Out now in @natcomms.nature.com ⤵️univie.ac.at3D structure of DNA may explain how cephalopods evolved complex brainsStudy suggests that the 3D "entanglement" of DNA may help drive evolutionary innovation 0146
Reposted by Anton GoloborodkoMatthew Freeman @mjafreeman.bsky.social · 30/09/2026Yet another opportunity @dunnschool.bsky.social! We are looking for an Associate Professor If you have exciting research plans, @dunnschool.bsky.social is a great place: excellent science (and lovely people, obvs) www.path.ox.ac.uk/vacancy/asso...path.ox.ac.ukAssociate Professorship of Cancer Biology - Sir William Dunn School of Pathology in association with the Queen’s College. - Dunn SchoolWe are seeking to appoint an Associate Professor working in the area of the cellular and/or molecular biology of cancer, to be based in Oxford University’s Sir William Dunn School of Pathology. The ro... 02031
Reposted by Anton GoloborodkoRajiv McCoy @rajivmccoy.bsky.social · 08/10/2026Johns Hopkins Biology is hiring a tenure-track Assistant Professor in computational genetics and genomics. Applications due Nov. 8th: apply.interfolio.com/194924 In my experience, this has been an incredibly supportive environment to build a lab. Please feel free to reach out with any questions.apply.interfolio.com Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio 05057
Reposted by Anton GoloborodkoPlaschka lab @plaschkalab.bsky.social · 08/10/2026After excising an intron, the spliceosome gets trapped on the branched intron-lariat RNA. How are such dead-end spliceosomes terminated? Our latest paper led by @vytaute.bsky.social investigates the mechanism of spliceosome termination www.nature.com/articles/s41... (1/6) 37529
Anton Goloborodko @golobor.bsky.social · 03/10/2026A corporation that believes that AI is conscious AND is powerful enough to destroy human civilization AND pushes full steam ahead with its development would've fit great into the Fallout universe 110
Reposted by Anton GoloborodkoVictor Tatarskiy @greenrat.bsky.social · 30/09/2026Wait, what??? I think a lot of nerds in Russia are familiar with Eskov's book, but I always thought that a) nobody outside of Ru knows it b) Eskov writing was a bit tongue in chick, "look guys how clever I am" (compared to the "Black Book of Arda" which is more "serious" in tone 232
Reposted by Anton GoloborodkoRandall Munroe @xkcd.com · 02/10/2026Ground Effect xkcd.com/3305/ 263696330
Anton Goloborodko @golobor.bsky.social · 01/10/2026...yet another illustration why explicit, thoughtful modeling is still worth the time, as compared to using heuristics #methodsmatter 051
Reposted by Anton GoloborodkoNina Willburger @drnwillburger.bsky.social · 01/10/2026Fishing some 5,300 years ago: a Neolithic fishhook made of a wild boar tusk, wrapped with a fishing line. The size of the fishhook is 6.5 cm. It was used to catch pikes. Found in the lake-dwelling settlement of Arbon Bleiche 3, Switzerland. On display at Archäologisches Museum Frauenfeld 📷me 🏺 329661
Reposted by Anton GoloborodkoMarkus Sulzbacher @msulzbacher.bsky.social · 30/09/2026Die Stadt Wien ist Opfer einer Cyberattacke geworden. Unbekannte verschafften sich Zugriff auf die EDV und stahlen rund 26.000 interne Dokumente. Darunter befinden sich Daten von 6.000 Personen. Hinweise, dass sie veröffentlicht wurden, gibt es nicht. wien.orf.at/stories/3373...wien.orf.atCyberangriff auf Stadt WienDie Stadt Wien ist Opfer einer Cyberattacke geworden. Unbekannte verschafften sich Zugriff auf die EDV und stahlen rund 26.000 interne Dokumente. Darunter befinden sich Daten von 6.000 Personen. Hinw... 14118
Reposted by Anton GoloborodkoMark Peifer (He, him) @peiferlabunc.bsky.social · 29/09/2026For the last 34 years I have been on the faculty of the UNC-Chapel Hill Department of Biology and have never regretted that decision. This year we are hiring TWO new Assistant Professors in the broad area of Molecular, Cell, Developmental Biology 1/n bio.unc.edu 3152142
Anton Goloborodko @golobor.bsky.social · 27/09/2026This sentence assumes that condensed==inaccessible - is that established actually? It's not the first/only paper doing that, ofc, but what evidence supports this assumption? 120
Anton Goloborodko @golobor.bsky.social · 27/09/2026TIL 186 existed! (we started with ZX spectrum and then a 286) Makes sense, in retrospect. 210
Anton Goloborodko @golobor.bsky.social · 26/09/2026This was a great exercise in memory excavation. The top 5-ish ones I played when I was 7-8, so I recall little substance (single frames at most), but they bring out strong emotions 110
Anton Goloborodko @golobor.bsky.social · 26/09/2026could be! www.coreweave.com/pricing/clas... - A100 (2020-2021) is $2/hour (= $48/day = $15K/year at full utilization), so it's still making them good money. Also, all datacenter companies keep saying that they have more demand than they can supply. They are motivated to say that ofc, but... 020
Anton Goloborodko @golobor.bsky.social · 25/09/20265 years is way too conservative, though. The RTX 6000/A100s in our HPC cluster are still going strong and remain very useful after 6 years, and will probably stay in use for quite a while. 320
Reposted by Anton GoloborodkoInstitute of Molecular Biotechnology @imbavienna.bsky.social · 12/08/2026We are hiring! Join the de Groot Lab as a Master's Student / Research Intern in Computational Biology and Theoretical Modeling to develop a Bayesian method for comparing single-cell datasets by explicitly modeling measurement noise to bring out true biological variability. 013
Reposted by Anton GoloborodkoAdam Rogers @jetjocko.bsky.social · 23/09/2026Privatize the gains and socialize the apocalypse. 329855
Reposted by Anton GoloborodkoMaya Voichek @mayavoichek.bsky.social · 24/09/2026Super excited to share my postdoctoral work at @imbavienna.bsky.social @viennabiocenter.bsky.social - We discovered that some retrotransposons, or "jumping genes" 🧬, are able to spread from cell to cell via a new viral infectivity route. A short thread: 🧵👇 (1/7) 20259148
Reposted by Anton GoloborodkoRichard Sever @richardsever.bsky.social · 21/09/2026It's also worth reading the postscript about Bsky. Some won't agree, but after fleeing the unpleasantness of what twitter became, this community should be concerned it's created an echo chamber in which any departure from a line is attacked (reasonable discussion =/ tolerating bigotry/misinfo). 4172
Reposted by Anton GoloborodkoJoshua G. Schraiber @jgschraiber.bsky.social · 20/09/2026This is definitely what people don't realize I think. Where AI is *right now* is way way way better than you think. It's way better than even the biggest proponents think. And it's clearly still getting better 042
Reposted by Anton GoloborodkoS.E. Danesti @seedanesti.bsky.social · 19/09/2026Interviewer: "Where do you see yourself in 5 years?" Me: 1002050435
Reposted by Anton GoloborodkoNezar Abdennur @nvictus.bsky.social · 19/09/2026The 4DN Center for 3D Structure and Physics of the Genome proudly presents: "Stepwise reorganization of chromosome conformation and nuclear organization during stem cell differentiation". www.biorxiv.org/content/10.6... 14419
Reposted by Anton GoloborodkoAurele Piazza @aurelepiazza.bsky.social · 18/09/2026What molecular mechanisms underlie the needle-in-a-haystack search for homology required to fix a DNA break? In this preprint, we reveal multiple controls of homology search in cells: onset, coordination, reach and inactivation. www.biorxiv.org/content/10.6... 25119
Anton Goloborodko @golobor.bsky.social · 18/09/2026How come there's so little chat about *that*?.. the more I think about the scenario of devastating AI-augmented/driven wars or runaway military AI, the more my subjective P(doom) tends to 1.0. Am I missing some counter-factor? 4/4 000
Anton Goloborodko @golobor.bsky.social · 18/09/2026Furthermore, the current AI "leadership" doesn't seem to worry about these applications and, if anything, (in)directly encourages them through increased discussions of geopolitical competition and sovereignty 3/ 100
Anton Goloborodko @golobor.bsky.social · 18/09/2026War is ugly and, as I understand, every possible technical solution gets explored. War and oppression would benefit the most from centralized coordination and autonomous decision making. AI will be trained to hunt and kill people and do it with less and less oversight. 2/ 100
Anton Goloborodko @golobor.bsky.social · 18/09/2026With all the chatter on unintended AI misalignment, I worry much more about intended misalignment, namely, in military and law enforcement. 1/ 170
Reposted by Anton Goloborodkoconputer dipshit @davidcrespo.bsky.social · 02/08/2026exactly, “gen AI” just means “bad AI” in order to avoid the charge of being against *all* AI. I am also against bad AI. by defintion, everyone is against bad AI! 3366
Reposted by Anton GoloborodkosephirAmy @sephiramy.bsky.social · 17/09/2026how about some good news: new cat just dropped!!!! 5154211966
Reposted by Anton GoloborodkoLopes_Lab @lopeslab.bsky.social · 16/09/2026Thrilled to share a new important study from the lab, published today in @nature.com, showing how cohesin mediates efficient replication fork plasticity and stress response, using its loop extrusion activity to promote 3D contacts on replicating DNA: www.nature.com/articles/s41...nature.comCohesin reshapes replication fork contacts to aid fork slowing and reversal - NatureCohesin-mediated loop extrusion limits sister-fork coupling and tethers nearby replication forks under replication stress, promoting fork reversal and slowing fork progression to safeguard genome... 46935
Reposted by Anton GoloborodkoSergey Ovchinnikov @sokrypton.org · 17/09/2026Introducing highly experimental localfold.org Building on @martinsteinegger.bsky.social af2 webgpu port, @milot.bsky.social optimizations & jax ports of af3-like models by @marielle.bsky.social, Choonghwan Lee, Julia Buhmann. WARNING: runs directly on your 💻, may drain 🪫 & eat data📱 & overheat 🔥💻 26826
Reposted by Anton GoloborodkoJens Schmidt @jenscs83.bsky.social · 15/09/2026We are recruiting a postdoctoral fellow to study DNA damage repair via the homologous recombination pathway using quantitative cell biology approaches. The position will be initially supported for two years by the MSU Research Foundation Postdoctoral Scholars program. Please share! 1/5 11730
Reposted by Anton GoloborodkoIMP @impvienna.bsky.social · 15/09/2026Exciting news! We're thrilled to announce the six outstanding laureates of the International Birnstiel Award for Doctoral Studies in Molecular Life Sciences 2026! 🏆Congratulations to all awardees and honourable mentions! 🎉 1/ ➡️ www.imp.ac.at/news/article... 1214
Reposted by Anton GoloborodkoVijay Ramani @vram142.bsky.social · 14/09/2026Everything you wanted to know about single-molecule epigenomics but were too afraid to ask! Wonderful to co-write (h/t ENORMOUS lift by @arnaudkr.bsky.social) this primer on our nascent field. Also, a 💯 example of wonderful colleagues building something *together*, not in competition =)nature.comA practical guide to studying genome function using single-molecule genomicsNature Reviews Molecular Cell Biology - Single-molecule genomics methods are used to study the activity of regulatory factors on individual DNA molecules genome-wide, thereby enabling... 07526
Reposted by Anton GoloborodkoFena Ochs @fenaochs.bsky.social · 10/09/2026My lab at the Center for Gene Expression (CGEN), University of Copenhagen is looking for a motivated Postdoc interested in cohesin biology, 3D chromatin, and super-resolution microscopy. 📩 Please email your CV and letter of intent to fena.ochs(at)sund.ku.dk. 01822
Anton Goloborodko @golobor.bsky.social · 10/09/2026Personally, I am *very* excited about this development, as it paves the way for a new generation of scalable, robust, and easy-to-implement coarse-grained models of biological systems and also helps our lab enter this field. Please, let us know if you have any qs/comments/suggestions/future ideas! 000