Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

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In this study, the authors uncover how diverse inhibitory interneurons in the amygdala flexibly contribute to fear and safety learning, revealing a key role for inhibition in emotional memory and adap...

Gatto Lab researches sensorimotor adaption mechanisms and spinal cord circuits

Individual behaviours require the nervous system to execute specialised motor programs, each characterised by unique patterns of coordinated movements across body parts. Deep learning approaches for b...

Yao et al. developed a neuromechanical model based on experimental perturbations, aligning theory-predicted with genetically labeled cell types. This work highlights the importance of inhibitory inter...

The authors describe a sensory circuit involving the medial septum (MS), where MS glutamatergic neurons integrate food odours to prime satiety and regulate nutrient intake.

Various strategies targeting spinal locomotor circuitry have been associated with functional improvements after spinal cord injury (SCI). However, ...

studies the spinal cord circuits involved in sensorimotor adaptation.

Empowering Behavioral neuroscience with modern computing

Organizers Salil Bidaye, Max Planck Florida Institute for Neuroscience Ansgar Büschges, University of Cologne Graziana Gatto, University of Cologne Abdel El Manira, Karolinska Institutet Julie

Tolve et al. demonstrate that AP-2 stabilizes GRID2IP to regulate synaptic function in Purkinje cells. Loss of AP-2 disrupts synaptic connectivity, alters network activity, and impacts motor coordinat...

Tutas et al. show an unconventional role for autophagy in the regulation of glycolytic flux in cerebellar Purkinje cells by maintaining the levels of the glucose transporter GLUT2.

Rhythmic motor behaviors are generated by neural networks termed central pattern generators (CPGs). Although locomotor CPGs have been extensively characterized, it remains unknown how the neuronal pop...

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