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Nick Ingolia

@nickingolia.bsky.social
619 followers 547 following 12 posts

Translation and RNA Biology • Comprehensive and high-throughput experiments Professor, Molecular and Cell Biology, UC Berkeley

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Nick Ingolia @nickingolia.bsky.social · 29/09/2026
We are searching for a technician to work on disordered proteins and regulatory networks involved in mRNA regulation! careerspub.universityofcalifornia.edu/psc/ucb/EMPL...
careerspub.universityofcalifornia.edu
Careers
The Departments of Molecular and Cell Biology (MCB) and Integrative Biology (IB) together are among the largest academic departments at UC Berkeley. By several measures (including number of faculty and students, budget, and assigned square feet), these departments are larger than many UCB colleges and schools. The two departments represent over 186 faculty FTE (including Adjuncts, Professors of the Graduate School, active emeriti and 15 HHMI professors); 150 postdocs and other research positions; 375 graduate students; 80 department staff members; and 8 recharge centers. Financial resources include approximately $51M in annual extramural funding (which accounts for over half of the total sponsored research awards in the College of Letters & Science) and over $46M other fund sources. The department has 1,800 declared undergraduate majors (the largest majors on the Berkeley campus) and a total annual enrollment in classes of ~20,000. Department personnel are currently housed in seven buildings located in three widely separated parts of the campus.
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Chris Pickett @chrispickett5.bsky.social · 28/08/2026
I realize I’m a few days late to this discourse, but I wanted to add that I think this is a fairly dangerous moment for biomedical research. 1/
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J. Wren Kim @jwrenkim.bsky.social · 25/08/2026
I am super excited to start my faculty position at the Advanced Science Research Center (ASRC) and the Graduate Center at CUNY! I am looking forward to working with my new colleagues at this fantastic place for interdisciplinary research.
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UC Berkeley MCB @berkeleymcb.bsky.social · 14/08/2026
MCB is hiring Assistant Professors across 3 divisions!: 🧪BBS: aprecruit.berkeley.edu/JPF05483 🧬GGED: aprecruit.berkeley.edu/JPF05481 🦠IMM: aprecruit.berkeley.edu/JPF05486 🗓️ Application Deadline: October 19, 2026 🔗 Click the links or scan the QR codes to learn more and apply
MCB is hiring 3 Assistant Professor positions across 3 divisions: 

Biochemistry, Biophysics and Structural Biology (BBS); Genetics, Genomics, Evolution, and Development (GGED); and Immunology and Molecular Medicine (IMM)

BBS application link: https://aprecruit.berkeley.edu/JPF05483

GGED application link: https://aprecruit.berkeley.edu/JPF05481

IMM application link: https://aprecruit.berkeley.edu/JPF05486
Assistant Professor of Immunology and Molecular Medicine (IMM). IMM application link: https://aprecruit.berkeley.edu/JPF05486Assistant Professor of Biochemistry, Biophysics and Structural Biology (BBS). BBS application link: https://aprecruit.berkeley.edu/JPF05483Assistant Professor of Genetics, Genomics, Evolution, and Development (GGED). GGED application link: https://aprecruit.berkeley.edu/JPF05481
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Stirling Churchman @stirlingchurchman.bsky.social · 28/07/2026
RNA-seq tells us how much RNA is present in the cell. But to understand gene regulation, we need to easily measure the synthesis and decay rates driving this abundance. We introduce AIR-seq: analog intrinsic recoding sequencing. (1/6) www.biorxiv.org/content/10.6...
biorxiv.org
Analog intrinsic recoding measures RNA dynamics without chemical conversion
Steady-state RNA abundance measurements mask the synthesis and decay rates that shape gene expression. Analog intrinsic recoding sequencing (AIR-seq) repurposes the base-pairing properties of N4-hydro...
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Nick Ingolia @nickingolia.bsky.social · 27/07/2026
I mean, anything can be a singularity if you choose your coordinates badly enough...
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Kranzusch Lab @kranzuschlab.bsky.social · 12/06/2026
How do human cells defend against viruses? @sgfern.bsky.social discovers that human immune proteins named ISGs target ancient features of replication shared between animal and bacterial viruses – opening analysis of human immunity to the power of bacterial genetics www.biorxiv.org/content/10.6...
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Doudna Lab @doudna-lab.bsky.social · 27/04/2026
We present VIPR, a phage-encoded RNA-guided system that recognizes DNA with a noncontiguous code unlike CRISPR. Tiny, programmable, possibly ancestral to CRISPR immunity; VIPR is built around a striking RNA-DNA-DNA triplex.
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Kenneth Loi @kenjmloi.bsky.social · 27/04/2026
Excited to share our discovery of a new programmable RNA-guided DNA-targeting system hiding inside bacteriophages that predates CRISPR. We call it VIPR (Viral Interference Programmable Repeat), and it uses an entirely new logic to find its targets. Thread + link below.
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Liana Lareau @lianafaye.bsky.social · 25/02/2026
This is my love letter to mRNA: an Ignite talk I gave as a fundraiser for the Lawrence Hall of Science. Custom mRNA cancer vaccines could be a game changer, but anti-science policies make their future so uncertain. www.youtube.com/watch?v=WUlu...
youtube.com
Decoding mRNA: How AI & Vaccines Cure Cancer | Liana Lareau | Ignite Talk
YouTube video by Ignite Talks - Smart Ideas From Around the World
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UC Berkeley MCB @berkeleymcb.bsky.social · 06/01/2026
Congratulations to MCB postdoc Joseph Lobel (Ingolia Lab) on receiving the 2026 RNA Society Scaringe Young Scientist Award! 👏🎉 @rnasociety.bsky.social @nickingolia.bsky.social mcb.berkeley.edu/news-and-eve...
MCB postdoc Joseph Lobel (Ingolia Lab) receives the 2026 RNA Society Scaringe Young Scientist Award
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UC Berkeley MCB @berkeleymcb.bsky.social · 30/09/2025
Congrats to our 2025 MCB Outstanding Postdoc Award recipients who are being honored for their excellence in research, leadership, and service! 👏🎉Erin Doherty @erinedoherty.bsky.social, Kevin Eislmayr, Naohiro Kuwayama, & Joseph Lobel mcb.berkeley.edu/news-and-eve...
2025 MCB Outstanding Postdoc Award recipients
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Liana Lareau @lianafaye.bsky.social · 07/08/2025
This preprint from Helen Sakharova is one of the coolest things to come out of my lab: “Protein language models reveal evolutionary constraints on synonymous codon choice.” Codon choice is a big puzzle in how information is encoded in genomes, and we have a new angle. www.biorxiv.org/content/10.1...
biorxiv.org
Protein language models reveal evolutionary constraints on synonymous codon choice
Evolution has shaped the genetic code, with subtle pressures leading to preferences for some synonymous codons over others. Codons are translated at different speeds by the ribosome, imposing constrai...
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McSweeney's @mcsweeneys.net · 17/07/2025
"Writers have been using me long before the advent of AI. I am the punctuation equivalent of a cardigan—beloved by MFA grads, used by editors when it’s actually cold, and worn year-round by screenwriters. I am not new here."
buff.ly
The Em Dash Responds to the AI Allegations
“In recent months, a curious fixation has emerged in corners of academia: the em dash. More specifically, the apparent moral panic around how it is...
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Liana Lareau @lianafaye.bsky.social · 09/06/2025
Smallpox inoculation was practiced throughout the 1700s; George Washington mandated this life-saving measure for the whole Continental Army in 1777. It was supplanted by the first-ever vaccine in 1796, a huge breakthrough supported by government grants in the UK. Just randomly on my mind.
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Michael Baym @baym.lol · 14/05/2025
Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab
A screenshot of the termination notice showing "Outstanding Investigator Grants"A screenshot of the termination notice with "This award is terminated effective the date of this award, due to unsafe antisemitic actions that suggest the institution lacks concern for the safety and wellbeing of Jewish students." highlighted
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Stirling Churchman @stirlingchurchman.bsky.social · 21/04/2025
My father-in-law, Jack Strominger, and I wrote a letter to the @wsj.com editor about the current threats to science due to Trump's funding freeze. Please repost! www.wsj.com/opinion/scie...
wsj.com
Opinion | Science Suffers With Trump’s Funding Freeze
America’s scientific enterprise demands reliable stewardship, not destabilizing political intervention.
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Vikram Paralkar @paralkarlab.bsky.social · 05/02/2025
I was stunned by this work from Kathleen Collins' lab (Berkeley) when I heard her present this at a FASEB meeting! What a crazy innovative idea: Adapting the R2 retrotransposon to efficiently insert any custom transgene directly into RIBOSOMAL DNA ARRAYS! 🤯🤯🤯 The applications are endless....
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Stephen Floor @snf.bsky.social · 18/12/2024
Great work from Gloria Brar’s group on the role of paralogous RNA helicases in the heat shock response. Surprising increase in growth at high temperature and impact of a short motif! Also important implications of the role of biomolecular condensation. Awesome www.cell.com/cell-reports...
cell.com
Analyses of translation factors Dbp1 and Ded1 reveal the cellular response to heat stress to be separable from stress granule formation
Kuwayama and Powers et al. reveal differences in function for two related RNA remodelers. Dbp1 is poor at stimulating translation, but, when expressed instead of Ded1, it prevents cells from halting growth upon heat stress. This depends on a short disordered Ded1 region but not stress granule formation or reduced translation.
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Lori Passmore @lapassmore.bsky.social · 21/10/2024
New work from the lab! James Stowell led this project showing the importance of multivalency and phospho-regulation in mRNA decay. This has many parallels with other mechanisms in gene expression. biorxiv.org/cgi/content/...
biorxiv.org
Phosphorylation-dependent tuning of mRNA deadenylation rates
mRNA decay is a major determinant of gene regulation that is controlled through shortening of mRNA poly(A) tails by the Ccr4-Not complex. The specificity of deadenylation can be mediated through RNA a...
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John Prensner @johnprensner.bsky.social · 10/09/2024
1/ Did you know the genome might have hidden protein-coding genes? In the years since the Human Genome Project, research has been tied to a set of 20,000 protein-coding genes. But the ‘dark genome’ has ‘dark proteins’ lurking in plain sight. 🧪 💻 + 🧬 🔎 microproteins www.biorxiv.org/content/10.1...
biorxiv.org
High-quality peptide evidence for annotating non-canonical open reading frames as human proteins
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
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Liana Lareau @lianafaye.bsky.social · 08/09/2024
Exciting work from Jinyoung Kim and Nick Ingolia enabling pooled CRISPRi screens in human cells by barcoded RNA readout. www.biorxiv.org/content/10.1...
biorxiv.org
CRISPRi with barcoded expression reporters dissects regulatory networks in human cells
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
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Liana Lareau @lianafaye.bsky.social · 29/11/2023
Spurred on by ribosome profiling and other cool methods, translation elongation has grown into a whole field with new surprises all the time (and new relevance for vaccine mRNAs!). Here’s our latest on why synonymous codons aren’t all the same. (Thread) www.biorxiv.org/content/10.1...
biorxiv.org
Codon optimality modulates protein output by tuning translation initiation
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
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Connor Horton @connorhorton.bsky.social · 21/09/2023
Check out our paper and the accompanying perspective by Kuhlman published today in Science about the surprising role of short tandem repeats in regulating eukaryotic transcription! www.science.org/doi/10.1126/... www.science.org/doi/10.1126/... A thread (1/11):
science.org
Short tandem repeats bind transcription factors to tune eukaryotic gene expression
Transcription factors directly bind repetitive sequences that need not resemble known motifs.
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