Lipid metabolism in fat cells (adipocytes) is coordinated by circadian rhythms, diet and environmental temperature, but how these diverse signals are…

Retatrutide activates the receptors for three hormones: glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1 and glucagon.

The behavioral effects of anesthetics are highly conserved across species, hinting at shared, fundamental mechanisms.

Carbon, hydrogen and nitrogen (atmophile elements) were thought to have accreted late during planetary formation, yet cosmochemical and astrophysical…

Acanthamoeba castellanii, an amoeba that causes infectious blindness, sits in a key evolutionary outgroup to humans and fungi, and its divergent…

Humans and other animals prioritize the visual processing of stimuli that signal rewards, but research has focused on tangible incentives such as money or…

Most neurodegenerative diseases are thought to spread through the brain by prion-like mechanisms, in which filamentous protein assemblies self-propagate by…

Pukaras, hillforts that are very common in the Andean highlands, date overwhelmingly to 1250 to 1500 CE, reflecting a period of widespread concern with…

Mitochondria arose about 2 billion years ago from the endosymbiosis of a bacterium with an archaea-related host cell.

The Sun is the largest energy source in the solar system, which the authors say warrants considering how future AI infrastructure could most efficiently tap…

People often act without knowing exactly how their actions affect others. Across nine preregistered online experiments with 8,769 adults, predominantly US…

Whole-organism malaria vaccines made from liver-infective sporozoites give high levels of sterile protection against pre-erythrocytic (liver-stage)…

The authors introduce Ataraxos, an AI for the board wargame Stratego built on general techniques they developed for self-play reinforcement learning and for…

Using unbiased whole-brain activity mapping in mice, the authors looked for circuits that previous adversity remodels to heighten sensitivity to later stress.

The authors propose that butterflies' high-contrast wing patterns work together with their flight to create visual illusions that confuse predators, and…

The authors made high-precision triple oxygen isotope measurements on insoluble organic matter from a diverse suite of carbonaceous chondrite meteorites.

In quantum field theory, when the potential energy between two particles grows with their separation as if they were joined by a string, new particle pairs…

The authors combined whole-brain developmental projection maps with single-cell transcriptomics to work out how serotonin neurons wire the forebrain after…

44 peer-reviewed results joined Frontier's index from 21 to 30 September, led by neuroscience and biomedicine; an AI climate-risk framework tops it at 76.

Earlier studies of network dynamics suggested that heterogeneity among nodes inhibits stability, which is at odds with how common inherently heterogeneous…

Pilus-dependent phages that infect Pseudomonas aeruginosa attach to its type IV pilus, whose major subunit, PilA, shows extensive sequence and chemical…

Using a single-nucleus transcriptomic atlas spanning the human lifespan, the authors show that cell types in the dorsolateral prefrontal cortex follow…

Using fruit flies, the authors show that restricting protein intake during the larval stage extends adult lifespan by reducing the levels of storage proteins.

The authors present HIDEN-SEQ (hidden Acr-enabled transposon-insertion sequencing), a transposon-insertion sequencing method for phages that systematically…

TU Delft gave a 44 g drone rat-like whiskers to fly, map and find exits in pitch darkness, with no camera or LiDAR. Inside the 2026 tactile-flight result.