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Francesco Gobbo

@franzgbb.bsky.social
170 followers 173 following 66 posts

Italian in Scotland 🇪🇺🇮🇹🏴󠁧󠁢󠁳󠁣󠁴󠁿 Neuroscience Researcher at Uni Edinburgh in Cognition and Neurodegeneration 🧠 He/him 🏳️‍🌈 Travel + language nerd 🌏🦜

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Reposted by Francesco Gobbo
Bertoglio lab (FMC/UFSC) @bertogliolab.bsky.social · 24/09/2026
www.nature.com/articles/s41...
nature.com
Navigational strategy dictates hippocampal representation of space in an everyday memory task - Nature Communications
Neurobiology of spatial memory is not fully understood. Using two behavioral tasks, authors demonstrate that the precision of spatial representations is lower in rats using egocentric coordinates, and...
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Francesco Gobbo @franzgbb.bsky.social · 28/09/2026
Thank you, looks super interesting!
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Francesco Gobbo @franzgbb.bsky.social · 28/09/2026
Thank you Hugo! Looks like a great paper, on my reading list!
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Francesco Gobbo @franzgbb.bsky.social · 28/09/2026
This would have not made possible without my coauthors Rufus, @adrian-du.bsky.social, Elena, @tsememorylab.bsky.social, Nuria, Omer, Kathrine, Patrick, Adana, Mark, @simonschultz.bsky.social and Richard for their work, and the support of all of my colleagues and science buddies!
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Francesco Gobbo @franzgbb.bsky.social · 28/09/2026
Overall, our work shows the ability of our brain to flexibly allocate resources to solve memory based tasks!
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Francesco Gobbo @franzgbb.bsky.social · 28/09/2026
When they used allocentric coordinates instead, space respresentation was more accurate. Furthermore, inhibiting hippocampal activity during decision making increased the number of errors in identifying the position of their rewards.
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Francesco Gobbo @franzgbb.bsky.social · 28/09/2026
When rats used egocentic, or self-centred coordinates, hippocampal representations were less precise, suggeting that rats were making little use of them to decide about their goals.
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Francesco Gobbo @franzgbb.bsky.social · 28/09/2026
We trained two groups of rats using egocentric or allocentric coordinates in a memory based task and recorded CA1 activity with miniscopes. We then compared the quality of hippocampal representations between the two groups.
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Francesco Gobbo @franzgbb.bsky.social · 28/09/2026
After a long journey it's finally out! My work on navigation strategy-dependent hippocampal representations during plnning with Richard Morris is out on @natcomms.nature.com ! rdcu.be/iS72dYSzBxya
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Reposted by Francesco Gobbo
Hugo Spiers @hugospiers.bsky.social · 06/07/2026
Just how goal-directed are hippocampal theta sweeps, anyway? Great News & Views from @adredish.bsky.social Lab on recent theta goal papers: www.nature.com/articles/s41... #neuroskyence
nature.com
Just how goal-directed are hippocampal theta sweeps, anyway? - Nature Neuroscience
Planning is a cognitive process that is thought to be grounded in hippocampal sequences, but recent studies have suggested that a simpler mechanism, fundamentally incompatible with those planning hypo...
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Francesco Gobbo @franzgbb.bsky.social · 06/07/2026
Excited for the start of the #FENS2026 ! I'm presenting on Thursday at 14-17:30. if you are interested in Astrocytes! Neurons! Synapses! in early AD models, come to my poster PS06-09PM-152 !
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Francesco Gobbo @franzgbb.bsky.social · 02/05/2026
Woofie
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Francesco Gobbo @franzgbb.bsky.social · 17/04/2026
The joy of living in the UK.. #cloud #UnitedKingdom #Edinburgh
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Reposted by Francesco Gobbo
Richard Sever @richardsever.bsky.social · 04/04/2026
CRUK goes green [OA] news.cancerresearchuk.org/2026/04/01/w...
news.cancerresearchuk.org
Why we won’t be funding open access publishing any more - Cancer Research UK - Cancer News
The open access movement was bold and promising, but ultimately disappointing. Now is the time to stop and call for a new way to make publishing work…
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Francesco Gobbo @franzgbb.bsky.social · 01/04/2026
Many thanks to our collaborators @clairedurrant1.bsky.social, @sorayam.bsky.social, Davide Gobbo, and Colin Smith; special thanks to our funders @ukdri.ac.uk and Alzheimer Scotland for the brain and tissue bank. #EJN
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Francesco Gobbo @franzgbb.bsky.social · 01/04/2026
New paper out this week with amazing synapse imaging! With the amazing @tspiresjones.bsky.social and our team we found that astrocyte processes protect synapses from amyloid beta-induced degeneration in an ex vivo slice model. onlinelibrary.wiley.com/share/GHTFFB...
onlinelibrary.wiley.com
Astrocyte Proximity Protects Synapses From Human Amyloid‐Beta Induced Degeneration in a Mouse Ex Vivo Model of Early Alzheimer's Disease
Reader environment loaded
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Francesco Gobbo @franzgbb.bsky.social · 15/12/2025
Wait..what?
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Reposted by Francesco Gobbo
Richard Sever @richardsever.bsky.social · 21/11/2025
"essays produced by ChatGPT are soulless, boring abominations. Words, phrases and punctuation rarely used by the average college student are pervasive." www.huffpost.com/entry/histor...
huffpost.com
I Set A Trap To Catch My Students Cheating With AI. The Results Were Shocking.
"Students are not just undermining their ability to learn, but to someday lead."
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Francesco Gobbo @franzgbb.bsky.social · 15/11/2025
On Sunday, don't miss the Presidential Special Lecture by the one and only @tspiresjones.bsky.social ! #SfN25 #SfN2025 #Alzheimer's #synapses #glia
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Francesco Gobbo @franzgbb.bsky.social · 15/11/2025
Interested in Alzheimer's Disease, astrocytes, synapses and lost of beautiful images? Come and listen to my talk tomorrow at NANO 002.12 #SfN2025 #SfN25 #neuroscience #astrocytes #glia
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Francesco Gobbo @franzgbb.bsky.social · 23/09/2025
@ambisocial.bsky.social @bidotorg.bsky.social @uoestaffpride.bsky.social
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Francesco Gobbo @franzgbb.bsky.social · 23/09/2025
Today is Bisexual Visibility Day, marking the end of Bisexual Awareness Week #BiWeek 🏳️‍🌈 Happy #BiDay! 💙💜❤️
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Francesco Gobbo @franzgbb.bsky.social · 19/09/2025
Happy Bisexual Awareness Week! #BiWeek 🏳️‍🌈 💙💜❤️
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Francesco Gobbo @franzgbb.bsky.social · 18/07/2025
For #FluorescenceFriday, a hippocampal neuron expressing tagBFP among ECFP astrocytes
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Francesco Gobbo @franzgbb.bsky.social · 26/06/2025
TAX👏THE👏RICH👏
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Reposted by Francesco Gobbo
Women in Neuroscience UK @handle.invalid · 06/06/2025
🎬 Behind the Science Spotlight - Part 2 with @britishneuro.bsky.social President Prof Tara Spires-Jones What do fly experiments, negative data & media exposés have in common? They’re all part of @tspiresjones.bsky.social’s story.
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Francesco Gobbo @franzgbb.bsky.social · 04/06/2025
Excited for today's Dementia Masterclass! @britishneuro.bsky.social
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Francesco Gobbo @franzgbb.bsky.social · 30/05/2025
Plot twist: it's the same railway
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Reposted by Francesco Gobbo
Optogenetics Gordon Research Conference @optogrc.bsky.social · 23/05/2025
📆 Mark your calendars: #OptoGRC2026 is headed back to Tuscany, May 10-15, 2026! We look forward to reuniting with our amazing community for a week of great science, thoughtful discussions & shared time with colleagues. More details coming soon👇🏽 tinyurl.com/esvrabsu
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Francesco Gobbo @franzgbb.bsky.social · 22/05/2025
OMG that's horrible! Thank you for sharing that!
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Reposted by Francesco Gobbo
Paul Frankland @franklandlab.bsky.social · 14/05/2025
Sharing a new paper from the lab. This paper, led by Sangyoon Ko, represents a merging of two longstanding research themes in the lab-- adult neurogenesis and systems consolidation. rdcu.be/el18q A short thread follows for those interested. 1/n
rdcu.be
Systems consolidation reorganizes hippocampal engram circuitry
Nature - A study shows that loss of memory precision associated with systems consolidation can be explained by neurogenesis-dependent reorganization of engram circuitry within the hippocampus over...
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Francesco Gobbo @franzgbb.bsky.social · 14/05/2025
However, I don't think there's concluding evidence for that, possibly because it's unclear how this model can be falsified and therefore tested.
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Francesco Gobbo @franzgbb.bsky.social · 14/05/2025
Well you posit that traces form on preestablished (or established upon memory formation) within the hippocampus, on something that may resonate with theories such as relational memory.
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Francesco Gobbo @franzgbb.bsky.social · 14/05/2025
Thank you!
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Francesco Gobbo @franzgbb.bsky.social · 13/05/2025
Thank you for your interest! It is an interesting take, perhaps you will find Widloski et al (2022) useful in this sense.
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Francesco Gobbo @franzgbb.bsky.social · 12/05/2025
Thanks to my coauthors @simonschultz.bsky.social @tsememorylab.bsky.social @elena-faillace.bsky.social and Bsky-less Rufus, Adrian, Nuria, Adana, Patrick, Mark and Richard
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Francesco Gobbo @franzgbb.bsky.social · 12/05/2025
Last, we inhibited this activity and found that this activity was necessary to correcly decide to go to the correct reward location, but only in allocentric animals!
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Francesco Gobbo @franzgbb.bsky.social · 12/05/2025
Then, we used miniscopes to look into the hippocampus activity in the two tasks and found that egocentric representations were less precise
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Francesco Gobbo @franzgbb.bsky.social · 12/05/2025
First, we developed two protocols so rats would use allocentric or egocentric coordinates
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Francesco Gobbo @franzgbb.bsky.social · 12/05/2025
If you are a hippocampus fan 🧠, check out our new preprint on Memory and Route planning in navigation! 🍪🐀 A multi-year, multi-person effort with lots of cool stuff: behaviour🧭miniscopes🔬and optogenetics🚨 www.biorxiv.org/content/10.1... #science #hippocampus #memory #navigation #replay #miniscopes
biorxiv.org
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Reposted by Francesco Gobbo
Lisa Genzel (she/her) @lgenzel.bsky.social · 06/05/2025
We are hiring! PostDoc position on my ERC for wire-less electrophysiology in our 9mX5m rat HexMaze! Experience with tetrodes or silicone probes required. Contact me for questions! www.genzellab.com/we-are-hiring
genzellab.com
We are hiring! — Semantic memory Lab
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Francesco Gobbo @franzgbb.bsky.social · 30/04/2025
Fight.
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Reposted by Francesco Gobbo
The Guardian @theguardian.com · 30/04/2025
Living human brain tissue used to mimic Alzheimer’s in breakthrough study
theguardian.com
Living human brain tissue used to mimic Alzheimer’s in breakthrough study
Exclusive: British team exposed live cells to toxic proteins to gather rare insight into how dementia develops Scientists have used living human brain tissue to mimic the early stages of Alzheimer’s disease, the most common form of dementia, in a breakthrough that will accelerate the hunt for a cure. In a world first, a British team successfully exposed healthy brain tissue from living NHS patients to a toxic form of a protein linked to Alzheimer’s – taken from patients who died from the disease – to show how it damages connections between brain cells in real time. Continue reading...
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Francesco Gobbo @franzgbb.bsky.social · 26/04/2025
Interested in #astrocytes, #synapse activity and loss in #AD? Come to my poster at #BNA2025 on Monday afternoon! Will also give a flash talk at 14:10. See you there!
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Reposted by Francesco Gobbo
Dr Alessio Veneziano @aveneziano.bsky.social · 17/04/2025
Human sex is not binary from a biological perspective ♀️♂️. Female/Male - as well as XX/XY - is an incomplete model to describe sex in humans. A good read about the subject 👇 🧪 #science #STEM www.scientificamerican.com/article/sex-...
scientificamerican.com
Sex Redefined: The Idea of 2 Sexes Is Overly Simplistic
Biologists now think there is a larger spectrum than just binary female and male
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Reposted by Francesco Gobbo
Ross Carroll @rosscarroll.bsky.social · 25/02/2025
When I worked in UK academia I recall hearing of a Japanese man who was baffled at how Britain had decided to run its universities like firms. “Why? Your universities are excellent and your firms are terrible.”
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Reposted by Francesco Gobbo
Caitlin Mallory @caitlinmallory.bsky.social · 31/01/2025
1/19 I’m thrilled that my postdoctoral work, with John Widloski and David Foster is now out in @science.org, along with a wonderful preview by Daniel Bendor!
science.org
The time course and organization of hippocampal replay
The mechanisms by which the brain replays neural activity sequences remain unknown. Recording from large ensembles of hippocampal place cells in freely behaving rats, we observed that replay content i...
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Reposted by Francesco Gobbo
Kate Jeffery @katejj.bsky.social · 11/01/2025
This is a really nice review of the career of a tremendous scientist and wonderful person who will be greatly missed
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Francesco Gobbo @franzgbb.bsky.social · 10/01/2025
I have a couple come find me on Monday:)
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Francesco Gobbo @franzgbb.bsky.social · 10/01/2025
On print at last! #hippocampus #neuroscience
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