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Frank S. David

@franksdavid.bsky.social
1.2K followers 622 following 292 posts

Biotech R&D strategy @ Pharmagellan. Prof of Practice of Biotech @ Tufts Biology. Bio, books, blog & more at www.pharmagellan.com. #biosky

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Frank S. David @franksdavid.bsky.social · 13/09/2026
Best. Day. Ever.
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Frank S. David @franksdavid.bsky.social · 21/10/2025
Hey, folks -- please show some love/encouragement to a recent Bio MS grad (on the job market!) who's blogging about biomedical research in the Mideast and North Africa: www.linkedin.com/newsletters/...
linkedin.com
MENA Science | LinkedIn
I want to delve into and highlight high-impact research coming out of Arab and North African countries.
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Frank S. David @franksdavid.bsky.social · 18/09/2025
Hi, folks! I just posted another "links list" of biopharma-relevant stuff that caught my attention (incl. "AI and Alzheimer's cures" -- color me skeptical). mailchi.mp/pharmagellan...
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Frank S. David @franksdavid.bsky.social · 14/08/2025
New essay on measuring biopharma innovation in The Incidental Economist -- led by @sukhunkang.bsky.social; I pitched in: theincidentaleconomist.com/wordpress/me...
theincidentaleconomist.com
Measuring Biopharmaceutical Innovation in the Modern Era | The Incidental Economist
As the Inflation Reduction Act empowers Medicare to negotiate drug prices based in part on clinical benefit, and as the FDA more closely scrutinizes accelerated approvals, a fundamental question has b...
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David Shaywitz @dshaywitz.bsky.social · 08/08/2025
Great curated list, @franksdavid.bsky.social -and would have expected no less!
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Frank S. David @franksdavid.bsky.social · 08/08/2025
My latest "link list": mailchi.mp/pharmagellan...
mailchi.mp
Links: Ph2 failures, pharma innovation, oncology R&D, etc.
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Frank S. David @franksdavid.bsky.social · 29/07/2025
My unsexy but easy suggestion for Marty Makary M.D., M.P.H. on boosting "radical transparency" at the FDA: www.statnews.com/2025/07/29/f...
statnews.com
How the FDA can score quick wins on transparency
Improving how the FDA disseminates already-public information about approved drugs may be unsexy, but it would be a big step toward the era of “radical transparency.”
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Frank S. David @franksdavid.bsky.social · 13/07/2025
New (from me): blogging advice for folks who want to get into biotech strategy or finance, incl. resources, examples, and tips to get started: www.linkedin.com/pulse/you-sh...
linkedin.com
You should start a biotech blog
A lot of students and young professionals ask me how to get into biotech strategy, consulting, or investing (esp. venture capital).
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Saloni @scientificdiscovery.dev · 02/07/2025
Ask me anything! If you have questions about writing, podcasting, global health, medical innovation, data, or anything else, I'll be doing an AMA on the EA Forum next week. It's between 6-8pm BST on July 8th but you can also leave qs here in advance: forum.effectivealtruism.org/posts/i2DtGA...
AMA: Saloni Dattani
by Toby Tremlett🔹, salonium
Jul 2
1 min read
 1
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Ask Me Anything
Frontpage
+ Add topic
AMA: Saloni Dattani
Question ideas:
1 comment
Saloni will answer the questions in this AMA between 6-8pm BST on July 8th. Leave your questions as comments, and upvote other questions you’d like to see answered.

If you’ve been around EA for a while, and you’re interested in global health, you’ve probably read Saloni Dattani before.

Saloni writes about global health at Our World In Data and is a co-founder and editor of Works in Progress magazine. She’s also recently started a podcast, Hard Drugs, with Jacob Trefethen. She also (somehow) finds time to write a great blog, Scientific Discovery.

She’s recently written on:

The decline in cancer mortality, and how it’s not all down to decline in smoking.
How we calculate fertility rates, and why just calculating the total fertility rate leads us astray.
And she delivered a talk at EA Global London on the data that shapes global health.
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Frank S. David @franksdavid.bsky.social · 02/07/2025
Hi, folks -- here's my inaugural "links list" of recent items that caught my eye in biotech R&D and other areas. Please let me know what you think! eepurl.com/jih0E2
eepurl.com
Links: Chinese biotech, P3 failures, pharma revenue drivers, etc.
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Frank S. David @franksdavid.bsky.social · 20/06/2025
Generics FTW. Also, anyone even mildly interested in drug pricing should read Peter Kolchinsky’s “Great American Drug Deal”.
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David Miller @biotechmiller.bsky.social · 20/06/2025
While the data have been known for some time, I have to say I keep catching myself staring off into space contemplating how life will change for so many with $GILD approval of a twice-yearly shot capable of preventing 99.9% of HIV cases. Remarkable.
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Frank S. David @franksdavid.bsky.social · 19/06/2025
Good resource for biotech entrepreneurs (HT @wilbanks.bsky.social)
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Frank S. David @franksdavid.bsky.social · 17/06/2025
Apparently hope *is* a strategy after all. endpoints.news/roche-moves-... by @leileiwu.bsky.social of Endpoints
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Frank S. David @franksdavid.bsky.social · 13/06/2025
Good piece —>
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Frank S. David @franksdavid.bsky.social · 13/06/2025
Great thread — bookmarking for my drug dev class. HT @thewonkologist.bsky.social
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Frank S. David @franksdavid.bsky.social · 12/06/2025
Love this — I’ve sent it to many Tufts Bio students. (So far only 1 has started a blog, but I’m not giving up.)
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Alexander Berger @albrgr.bsky.social · 11/06/2025
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Frank S. David @franksdavid.bsky.social · 11/06/2025
Me: “FIVE hours?” Also me: <hits the “subscribe” button>
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Frank S. David @franksdavid.bsky.social · 10/06/2025
I don’t follow the generics market closely, let alone international Gx — so I found this piece by @dereklowe.bsky.social particularly bananas! Go read it. www.science.org/content/blog...
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Frank S. David @franksdavid.bsky.social · 10/06/2025
Good reading recs here from Jacob Trefethen of Open Phil: blog.jacobtrefethen.com/science-writ...
blog.jacobtrefethen.com
Science writing from the last two years that stuck with me
This list consists of writing that ticked two boxes: 1) did I think about the article again more than a week after reading it?, and 2) was it written for a popular audience? So, academic papers, inclu...
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Frank S. David @franksdavid.bsky.social · 06/06/2025
Valid point
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David Shaywitz @dshaywitz.bsky.social · 05/06/2025
Really interesting post from new Ch Med Ofc of Oura Ring pointing to next steps for device: integration w traditional patient care systems (presumably Epic etc), impact on health behavior… (in previous role at Apple his expertise included health data interoperability…) cc @franksdavid.bsky.social
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David Shaywitz @dshaywitz.bsky.social · 05/06/2025
Or simply: Get lucky: pick winners.
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Frank S. David @franksdavid.bsky.social · 05/06/2025
Good template for a clear paper abstract — HT @johnholbein1.bsky.social (who credits @fgilardi.bsky.social)
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Frank S. David @franksdavid.bsky.social · 05/06/2025
New paper on pharma revenue drivers by IDEA Pharma — here’s the TL;DR (w/apologies to Michael Pollan; IYKYK): “Spend on R&D. Not too much. Mostly Phase 3 trials.” www.ideapharma.com/insights/rev...
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Frank S. David @franksdavid.bsky.social · 05/06/2025
New “Healthspan” whitepaper by the folks at Whoop. I’m skeptical of these sorts of things but I haven’t read it yet and this isn’t my expertise. Curious to hear thoughts from @dshaywitz.bsky.social and others who follow this area. www.whoop.com/us/en/theloc...
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Frank S. David @franksdavid.bsky.social · 05/06/2025
Most cogent “bear case” I’ve read on where we are / where we’re going on AI. By Dwarkesh Patel: www.dwarkesh.com/p/timelines-...
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Frank S. David @franksdavid.bsky.social · 04/06/2025
Big “college student seeing final course grade” energy(Rep. Jason Smith (R-MO) via NYT).
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Julie Blommaert @drjulieb.bsky.social · 04/06/2025
This is a really fun question to throw at your colleagues when you’re a biologist
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David Shaywitz @dshaywitz.bsky.social · 04/06/2025
My new Timmerman Report column discusses recent @nejm.org study linking exercise, cancer recov, focusing on methodological ?s of Dr. J Mandrola, pt-focused concerns of Jennifer Goldsack timmermanreport.com/2025/06/nejm... @alicecallahan.bsky.social @franksdavid.bsky.social @meganranney.bsky.social
timmermanreport.com
NEJM Study Linking Exercise, Cancer Recovery Raises Two Concerns: What If It’s Wrong?  What If It’s Right? - TimmermanReport.com
This week featured a rare crossing of the streams, as the buttoned-down world of cancer research met the buzzy world of exercise and wellness.  One result: a randomized controlled study of exercise in...
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Frank S. David @franksdavid.bsky.social · 02/06/2025
Smart post by John Mandrola on limitations of the “exercise cures cancer” paper in NEJM: www.sensible-med.com/p/exercise-i...
sensible-med.com
Exercise is Great but It’s Not a Cancer Drug
The CHALLENGE trial ignited social media with its great story of exercise as a cancer therapeutic. But liking a conclusion is not a reason to stop thinking.
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Frank S. David @franksdavid.bsky.social · 30/05/2025
My 2c: if a Ph 3 trial hits 1 of 2 co-primary EPs, the PR should say so in the headline. That said, lede of main text in this case is very clear. So, I’d give “partial credit”. Case: www.businesswire.com/news/home/20... My prior take on biotech PR shenanigans: www.pharmagellan.com/blog/red-fla...
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Frank S. David @franksdavid.bsky.social · 29/05/2025
@deenamousa.com’s new post on $/QALY is excellent! (Re-posting with link.) newsletter.deenamousa.com/p/how-much-d...
newsletter.deenamousa.com
How much do you value a year of life?
Part 1: What people say
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Frank S. David @franksdavid.bsky.social · 29/05/2025
I love the $/QALY topic so much, and Deena’s post is excellent!
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Frank S. David @franksdavid.bsky.social · 26/05/2025
GLP-1 drugs are a health econ ticking time bomb… 1. Good summary today of the (huge) addressable population by WSJ’s Peter Loftus: www.wsj.com/health/pharm... 2. Pair it with ICER’s analysis last month of the cost-effectiveness and affordability issues: icer.org/wp-content/u...
wsj.com
Should Everyone Be Taking Ozempic? Doctors Say More People Could Benefit
Anti-obesity drugs are showing promise for an ever-expanding list of diseases
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Frank S. David @franksdavid.bsky.social · 24/05/2025
If you’re looking for a humorous literary break, this post by @ksetiya.bsky.social is for you: ksetiya.substack.com/p/selected-a...
ksetiya.substack.com
Selected Amazon Reviews
Let us celebrate one of the great social and technical breakthroughs of the 2010s: the invention of the “Bic for Her,” a biro so ergonomic even the wife could use it—and so pretty she would want to.
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Frank S. David @franksdavid.bsky.social · 22/05/2025
Love this deep dive on upcoming sickle cell trial readouts by @plainyogurt21.bsky.social. Agree or disagree w/his points, he’s putting out some thoughtful, data-backed arguments. Biopharma needs more folks writing these sorts of posts! adus.substack.com/p/sickle-cel...
adus.substack.com
Sickle Cell Disease: previewing readouts from Pociredir and Mitapivat
Pociredir works, Mitapivat may work
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Frank S. David @franksdavid.bsky.social · 22/05/2025
Nice discussion of “effect you’d like to see” vs “effect you’d like to not miss” in context of clinical trial size/power. I hadn’t seen the issue presented this way before — very useful framing!
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Frank S. David @franksdavid.bsky.social · 17/05/2025
Great advice on writing accessible prose about technical topics by @dingdingpeng.the100.ci www.the100.ci/2024/12/01/w... HT @statsepi.bsky.social
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Frank S. David @franksdavid.bsky.social · 17/05/2025
1st FDA-cleared Alzheimer’s blood test — finally! Looking forward to digging into the data. Eric Snyder, Jake Olin, & I argued in 2012 that pharma would be a (the?) big winner from a non-imaging AD Dx. Arguments still basically hold up imho. www.nature.com/articles/nrd...
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Frank S. David @franksdavid.bsky.social · 16/05/2025
As we await more RFKJr/fluoride developments, check out this bananas piece about a start-up’s aim to eradicate cavities with a genetically engineered bacterium: undark.org/2024/04/17/b... via @undark.org
undark.org
Brushing with Bacteria: The Debate Over a GMO Tooth Microbe
One startup has said genetically modified microbe could prevent cavities. Experts, though, have safety concerns.
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Frank S. David @franksdavid.bsky.social · 16/05/2025
Should low-dose statins be available OTC in the US? (UK did this in early 2000s!) Read Alex Kesin’s case in favor: www.alexkesin.com/p/mr-secreta... Thoughts from @cnewtoncheh.bsky.social, @ethanjweiss.bsky.social?
alexkesin.com
Mr. Secretary, Reclassify the Statin
One regulatory stroke could save more American lives than a decade of health campaigns. You have the pen.
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David Shaywitz @dshaywitz.bsky.social · 14/05/2025
Another eg @stevelohr.bsky.social prescience: 2023 NYT on how today's AI killer app: paperwork: www.nytimes.com/2023/06/26/t... . Pairs w recent eg of @amgen.bsky.social applying it to R&D: blogs.microsoft.com/blog/2025/04... (h/t @franksdavid.bsky.social); my 2c pubmed.ncbi.nlm.nih.gov/39674343/
nytimes.com
A.I. May Someday Work Medical Miracles. For Now, It Helps Do Paperwork. (Published 2023)
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Stacie Dusetzina @dusetzinas.bsky.social · 13/05/2025
"President Trump could have walked softly and carried a big stick. As pharmaceutical investors see it, he instead stomped loudly and wielded a wet noodle." Great writing @matthewherper.bsky.social . www.statnews.com/2025/05/13/t...
statnews.com
To understand why investors rejoiced at Trump’s attack on drug firms, think like a pharma CEO
President Trump could have walked softly and carried a big stick. As pharmaceutical investors see it, he instead stomped loudly and wielded a wet noodle.
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Frank S. David @franksdavid.bsky.social · 13/05/2025
I think this is a great example of how AI tools can be useful in the near-term in big orgs. Letting AI loose on all the knowledge that’s locked away in PPT and PDF docs in a big pharma — about successful and failed programs — is a great use case. www.microsoft.com/en/customers...
microsoft.com
Amgen builds agent in 6 weeks with Copilot Studio to help accelerate R&D | Microsoft Customer Stories
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Frank S. David @franksdavid.bsky.social · 12/05/2025
Good stuff here —>
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Frank S. David @franksdavid.bsky.social · 12/05/2025
When it comes to the legal aspects of pharma policy, there’s almost always a @rachelsachs.bsky.social article/post…
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Frank S. David @franksdavid.bsky.social · 10/05/2025
WE’RE BACK, BABY! 🤑
NYT headline: Elizabeth Holmes’s Partner Has a New Blood-Testing Start-Up
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Frank S. David @franksdavid.bsky.social · 10/05/2025
Intersection btw the IRA and oncology R&D — nice summary of work by me and @dusetzinas.bsky.social in @onclive.bsky.social: www.onclive.com/view/inflati...
onclive.com
Inflation Reduction Act Leads to Seesaw Effect Between Oncologic Drug Savings and Development
Challenges may arise as there could be unintended consequences on oncologic drug development, access, and innovation.
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