iiinova — where your digital self keeps evolving

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mLife Journal @mlifejournal.bsky.social · 07/09/2026

Does HBV truly disappear after chronic hepatitis B treatment? New #mLife perspective introduces “cure-related occult HBV infection,” highlighting cccDNA persistence, HBV reactivation risk, and the need for long-term monitoring after HBsAg loss. doi.org/10.1002/mlf2...

Figure 1. Distinct immunological and cellular outcomes of three classes of OBI. ① Resolved acute self-limiting infection: Viral clearance occurs without repeated episodes of hepatic inflammation or hepatocyte death. ② Resolved chronic infection without intervention. ③ Functional cure.

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mLife Journal @mlifejournal.bsky.social · 15/09/2026

New in #mLife How does Coxiella burnetii keep host cells alive for intracellular replication? Zhang et al. reveal that the Dot/Icm effector CubL1 acts as an E3 ubiquitin ligase to inhibit host cell death by targeting an apoptosis nuclease. 🔗 doi.org/10.1002/mlf2...

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mLife Journal @mlifejournal.bsky.social · 07/09/2026

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mLife Journal @mlifejournal.bsky.social · 02/09/2026

mLife Volume 5, Issue 4 is now online! Explore new work on HBV cure, EBV models, bacterial effectors, AMR, microbial motility, ecosystem retrogression, iodate reduction, Southern Ocean bacteria, and coastal viromes. doi.org/10.1002/mlf2...

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mLife Journal @mlifejournal.bsky.social · 04/09/2026

Clinical Pseudomonas aeruginosa can carry a fourth T6SS, but is it functional? #mLife from @taogd.bsky.social lab: H4-T6SS becomes an active antibacterial machine when switched on, and TseMt is a pore-forming toxin with a 3.0 Å structure and a dedicated delivery route. #T6SS doi.org/10.1002/mlf2...

Figure 1. Model of H4-T6SS-mediated TseMt delivery and function in the clinical Pseudomonas aeruginosa isolate LYSZa7. The H4 locus is transcriptionally silent under the tested laboratory conditions but can be activated by promoter rewiring. TseMt adopts a soluble compact state, undergoes conformational rearrangement to expose membrane-interacting elements, and forms pores in target membranes. Its activity is neutralized by TsiMt and is proposed to be delivered by a PAAR4-VgrG4b-DUF4123 chaperone pathway.

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mLife Journal @mlifejournal.bsky.social · 04/09/2026

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mLife Journal @mlifejournal.bsky.social · 02/09/2026

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Miaoxiao Wang (Roy) @miaoxiaor.bsky.social · 11/08/2026

Excited to share our new Comment in @natcomms.nature.com: We join the discussion on the terminology of synthetic microbial communities and propose that SynComs should be more rigorously defined rather than simply renamed. www.nature.com/articles/s41...

nature.com

SynComs should be rigorously defined, not renamed - Nature Communications

Koch et al. propose replacing “synthetic microbial communities (SynComs)” with “defined microbial communities”. We argue that this substitution obscures the design-driven logic of SynCom research, and...

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Miaoxiao Wang (Roy) @miaoxiaor.bsky.social · 27/07/2026

Happy to share our latest review on @isme-microbes.bsky.social. We discussed how (intra- or interpopulation) cell-cell distances shape microbial interactions and enable community-level outcomes. Several hypotheses are proposed and we are testing them! doi.org/10.1093/isme...

doi.org

Influence of cell-cell distance on the ecology and evolution of microbial communities

Abstract. Microorganisms assemble into spatially structured communities in which neighboring cells are separated by highly heterogeneous cell-cell distance

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mLife Journal @mlifejournal.bsky.social · 23/07/2026

New in #mLife How do protists respond to multiple chemical stressors in wastewater microbiomes? Ding et al. show that protists remain highly resilient—and can even thrive—under combined exposure to ciprofloxacin, triclosan, and Cu²⁺. 🔗 doi.org/10.1002/mlf2...

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mLife Journal @mlifejournal.bsky.social · 20/07/2026

Ancient soils may lose biodiversity, but do they lose function? Using a 400,000-year ecosystem chronosequence, @deuterioh.bsky.social et al. found that microbial communities become more stable and increase genetic potential for N and P cycling despite nutrient depletion. 🔗 doi.org/10.1002/mlf2...

Figure 1. Graphical abstract illustrating how microbial communities adapt to long-term nutrient depletion across the Mendocino Ecological Staircase, a natural laboratory spanning nearly 400,000 years of ecosystem development.

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mLife Journal @mlifejournal.bsky.social · 20/07/2026

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mLife Journal @mlifejournal.bsky.social · 07/07/2026

mLife Volume 5, Issue 3 is now online! This issue features reviews, original research, methods, news & views, and correspondence across microbial ecology, virology, bacterial physiology, AMR, phage therapy, and environmental microbiology. Read the issue: onlinelibrary.wiley.com/toc/2770100x...

Cover: Antibiotic resistance is making many bacterial infections increasingly difficult to treat. Phages are promising therapy, but doctors currently lack fast methods to determine which phages can effectively kill a pathogen strain. In this issue, Xiao Han et al. invented a ramanome‐based phage susceptibility test (RPST) that is ten times faster than the conventional plaque assays. Within about 1 h, a Composite Infection Index (CII), derived by Raman microspectroscopy of bacteria, can determine whether a phage is effective, how strongly it infects bacteria, and how much phage is needed to start a successful
infection (pp. 369–382). By providing faster and more quantitative information than traditional assays, RPST accelerates the selection of effective phages for the therapy against drug-resistant infections.

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mLife Journal @mlifejournal.bsky.social · 07/07/2026

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mLife Journal @mlifejournal.bsky.social · 01/07/2026

New in #mLife: How do bacteria reverse toxin-imposed protein modifications? Chen and Guo et al. reveal that the Fic-1–AntF toxin–antitoxin complex from Pseudomonas bijieensis functions as a deAMPylase to regulate DNA gyrase activity. 🔗 doi.org/10.1002/mlf2...

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Waggoner Lab @labwaggoner.bsky.social · 25/06/2026

Cell-to-cell cooperation through membrane vesicles enhances antibiotic persistence @science.org @bcmfromthelabs.bsky.social www.science.org/doi/10.1126/... www.science.org/doi/10.1126/...

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mLife Journal @mlifejournal.bsky.social · 26/06/2026

New in #mLife: How do plant-pathogenic bacteria become resistant to streptomycin? Xu, Qian et al. identify a novel plasmid, pCM3, in Clavibacter michiganensis, revealing a phosphorylation-driven mechanism of streptomycin resistance. 🔗 doi.org/10.1002/mlf2...

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mLife Journal @mlifejournal.bsky.social · 17/06/2026

Exciting news! mLife’s 2025 JCR Impact Factor has reached 6.7, with a 5-year IF of 6.8, ranking Q1 in Microbiology (23/167). We thank our authors, reviewers, editors, and readers for their trust and support. Submit your next discovery to #mLife👉🏻https://onlinelibrary.wiley.com/journal/2770100x

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mLife Journal @mlifejournal.bsky.social · 09/06/2026

A new #mLife review explores a hidden carbon frontier: where land meets the sea. It shows how microbes transform, release, or preserve organic carbon, and proposes a land–sea MCP framework linking marine, soil, and mineral carbon pumps. Read more: doi.org/10.1002/mlf2...

Figure 1. Major milestones in the evolution of the MCP concept, from its marine origin to an integrated land–sea MCP framework linking marine MCP (microbial carbon pump), soil MCP, and MnCP (mineral-associated carbon pump) across ecosystems.

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mLife Journal @mlifejournal.bsky.social · 04/06/2026

Phage therapy is promising to kill drug-resistant bacteria—but finding the right phage is slow. A new ramanome-based phage susceptibility test (RPST) identifies efficient phages within ~1 h. Faster answers, better treatments! Paper: doi.org/10.1002/mlf2... Try RPST: github.com/qibebt-bioin...

Overview of ramanome‐based phage susceptibility test (RPST)

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mLife Journal @mlifejournal.bsky.social · 01/06/2026

🦠Mycobacteria include major human and animal pathogens, environmental species, and key models for studying bacterial cell envelopes, drug resistance, host adaptation, and phage defense. Six #mLife papers highlights recent advances in Mycobacteria research. ⬇️

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mLife Journal @mlifejournal.bsky.social · 27/05/2026

A major opportunistic pathogen, 🦠Pseudomonas aeruginosa causes hard-to-treat infections due to biofilms, virulence regulation and multidrug resistance. Explore 6 #mLife papers on its signaling, phages, motility, metabolism & therapy. ⬇️

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mLife Journal @mlifejournal.bsky.social · 18/05/2026

Infection Control in focus — #mLife highlights! From pathogen genomics and AMR surveillance to antimicrobial peptides, adjuvants, antibodies, nanomaterials and antivirulence strategies, these studies explore new ways to fight infectious disease. 🧵11 papers below ⬇️

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mLife Journal @mlifejournal.bsky.social · 14/05/2026

🧪 Microbial Techniques in focus — #mLife Collection II! From CRISPR tools and RNA editing to microfluidics, machine learning, antimicrobial nanomaterials and protein redesign, these papers showcase new methods powering microbiology. 🧵7 highlights below ⬇️

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Ákos T Kovács @evolvedbiofilm.bsky.social · 08/05/2026

Cell motility enhances metabolic coupling in spatially structured microbial communities (Pseudomonas aeruginosa PAO1-based experiments + modelling) bioRxiv by @miaoxiaor.bsky.social (Roy), Olga Schubert, and Martin Ackermann (@micsysecolab.bsky.social) www.biorxiv.org/content/10.6...

biorxiv.org

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mLife Journal @mlifejournal.bsky.social · 13/05/2026

📢 mLife Volume 5, Issue 2 is now online: doi.org/10.1002/mlf2... This issue features advances in anti-CRISPR biology, mNGS diagnostics, microbial stress tolerance, antibiotic persistence, gut repair, fungal epigenomics, rapid bacterial ID & more. 🧵Highlights below ⬇️

doi.org

Issue Information

Click on the article title to read more.

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Miaoxiao Wang (Roy) @miaoxiaor.bsky.social · 02/05/2026

New preprint from my postdoc work! We resolve a problem identified by Alma (doi.org/10.1038/s415...) : How can metabolic interactions persist despite clonal clustering separating partners? We show that cell motility disrupts clustering and enhances interactions. doi.org/10.64898/202...

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mLife Journal @mlifejournal.bsky.social · 29/04/2026

🎉Exciting news! We ( #mLife and #mBio @asm.org ) launch a joint award to recognize outstanding early-career researchers in microbiology. If you’re driving innovation, this is your chance to be recognized by leading journals! Apply or nominate by July 31 : 🔗 journals.asm.org/mbio/mlife-j...

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mLife Journal @mlifejournal.bsky.social · 29/04/2026

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mLife Journal @mlifejournal.bsky.social · 27/04/2026

Microbial Ecology Collection II — continued new insights from #mLife! From forests to oceans, from deep biosphere to Mars analogs, these studies reveal how microbes shape ecosystems, evolve, and adapt to extreme environments. 10 highlights below ⬇️

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mLife Journal @mlifejournal.bsky.social · 23/04/2026

Bacterial Pathogenesis in focus — #mLife highlights! From host–pathogen interactions to signaling, metabolism, and immune evasion, these studies reveal how bacteria sense, adapt, and cause disease across hosts. 12 key papers below ⬇️

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mLife Journal @mlifejournal.bsky.social · 21/04/2026

New #mLife article! How do desert cyanobacteria survive extreme desiccation? This study shows that osmotic signaling controls “sunscreen” biosynthesis (MAAs), enabling protection against dehydration stress and environmental extremes. 🔗 doi.org/10.1002/mlf2...

doi.org

Osmotic signaling governs sunscreen biosynthesis to safeguard desert cyanobacteria against desiccation

Mycosporine-like amino acids (MAAs) are natural sunscreens synthesized by a wide range of organisms. Although the induction of MAA production by ultraviolet radiation is well established, the signali...

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Miaoxiao Wang (Roy) @miaoxiaor.bsky.social · 18/04/2026

Our new work is out in @natwater.nature.com Bacteria release nano-sized membrane particles called Extracellular vesicles (EVs). We show that EVs enable protected delivery for nutrients and enzymes, reshaping metabolic interactions and biogeochemical cycling. doi.org/10.1038/s442...

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mLife Journal @mlifejournal.bsky.social · 18/04/2026

Cutting-edge microbial techniques you should know— #mLife Collection I! 🔥From AI-driven protein design to single-cell analysis, genome editing, and environmental monitoring, these mLife papers are redefining how we study and engineer microbes. 11 highlights below ⬇️

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mLife Journal @mlifejournal.bsky.social · 16/04/2026

Bacteriophages are evolving clever ways to outsmart CRISPR-Cas immunity! A latest review in #mLife highlights recent discoveries of noncanonical anti-CRISPR (Acr) mechanisms that go beyond simple steric blockade. Read more: doi.org/10.1002/mlf2...

Figure 1. The CRISPR‐Cas adaptive immune system and its sabotage by Anti‐CRISPR (Acr) proteins. This schematic illustrates the three stages of CRISPR‐Cas adaptive immunity, including adaptation, expression and processing, and interference, and the diverse inhibition mechanisms used by bacteriophage‐encoded Acr proteins to neutralize each stage.

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mLife Journal @mlifejournal.bsky.social · 16/04/2026

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Jianjun Wang @jjwang79.bsky.social · 14/04/2026

#iDOM is a R package designed to move beyond descriptive #FT-ICR-MS analyses by integrating statistical tools for #DOM composition, diversity, and environmental responses. Code & tutorials: github.com/jianjunwang/...

github.com

GitHub - jianjunwang/iDOM: Statistical analysis of dissolved organic matter based on high-resolution mass spectrometry

Statistical analysis of dissolved organic matter based on high-resolution mass spectrometry - jianjunwang/iDOM

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mLife Journal @mlifejournal.bsky.social · 14/04/2026

Microbial Ecology in focus — #mLife Collection I From single-cell heterogeneity to global biogeography, and from uncultured microbes to ecosystem functioning, these studies reveal how microbial communities are structured, function, and evolve. ⬇️10 papers in the Collection I

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mLife Journal @mlifejournal.bsky.social · 08/04/2026

🧪 Microbial Engineering in focus — #mLife highlights! From AI-driven protein design to synthetic biology, enzyme engineering, and microbiome-based therapeutics, these studies provide novel insights on how we can design, optimize, and harness microbes for biotechnology. 🧵11 key papers below ⬇️

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mLife Journal @mlifejournal.bsky.social · 05/04/2026

🦠 Microbiome in focus — Selected #mLife highlights! From human health and disease to evolution, metabolism, and new technologies, these studies showcase how microbiomes shape biology across scales. 🧵Explore 7 key papers below ⬇️

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mLife Journal @mlifejournal.bsky.social · 02/04/2026

New method for 🍄fungal systems by in #mLife! fCUT&Tag-Seq enables high-resolution chromatin profiling in fungi with low input and high sensitivity, opening new possibilities to study histone modifications and gene regulation in diverse fungal systems. 🔗 doi.org/10.1002/mlf2...

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mLife Journal @mlifejournal.bsky.social · 31/03/2026

🔥 Archaea are rewriting microbiology. From the origin of eukaryotes to life in extreme environments—these #mLife publications reveal how archaea shape evolution, ecology, and biotechnology. 🧵Explore 10 key papers below ⬇️

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mLife Journal @mlifejournal.bsky.social · 29/03/2026

A genome-wide screen in #mLife reveals that ATP levels universally govern ciprofloxacin tolerance across genetically distinct E. coli persisters. Low ATP states reduce antibiotic lethality, uncovering a conserved metabolic basis for persistence. 🔗 doi.org/10.1002/mlf2...

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mLife Journal @mlifejournal.bsky.social · 31/03/2026

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mLife Journal @mlifejournal.bsky.social · 29/03/2026

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mLife Journal @mlifejournal.bsky.social · 26/03/2026

New in #mLife! Berberrubine is a potent inhibitor against Helicobacter pylori. It suppresses bacterial growth by inducing oxidative stress and disrupting membrane integrity, revealing a promising lead for new anti-H. pylori therapies. 🔗 doi.org/10.1002/mlf2...

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mLife Journal @mlifejournal.bsky.social · 26/03/2026

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mLife Journal @mlifejournal.bsky.social · 23/03/2026

New in #mLife! Did microbial sulfur metabolism begin in hot environments on early Earth? This study reconstructs the evolutionary history of DsrAB, the key enzyme for dissimilatory sulfite reduction, suggesting a thermophilic origin in the Paleoarchean. 🔗 doi.org/10.1002/mlf2...

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mLife Journal @mlifejournal.bsky.social · 25/03/2026

New in #mLife! How do deep-subsurface microbes cope with extreme pressure? In the iron-reducing bacterium Orenia metallireducens, pressure-dependent physiological and metabolic adaptations sustain iron reduction across a wide hydrostatic pressure range. 🔗 doi.org/10.1002/mlf2...

Multi-level adaptation to a hydrostatic pressure gradient by Orenia metallireducens strain Z6. (A) Changes in Fe(II) concentrations over time under different pressures. As no significant increase in product concentrations was observed in the abiotic controls under the corresponding conditions, and thus, they were not illustrated. (B) Pseudo-zero-order Fe(III) reduction rates (pink diamonds, left axis) and biomass-normalized Fe(III) reduction rates (blue diamonds, right axis) under different pressures. (C) Membrane adaptation. Relative abundance of phospholipid fatty acids (PLFAs) at different pressures. (D) Schematic diagram of metabolic pathways. In the heatmaps, the five cells (from left to right) correspond to the cultures at 0.1, 10, 20, 30, and 40 MPa, respectively. The dashed arrow indicates a feasible but potentially insignificant pathway. (E) Conditional transcriptomic strategies under different pressures. The size of bubbles indicates the number of genes that are pressure-dependent and upregulated only under specific pressure(s). HHP, high hydrostatic pressure; PTS, phosphotransferase system.

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mLife Journal @mlifejournal.bsky.social · 23/03/2026

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