iiinova — where your digital self keeps evolving

Reposted by Esben Svenningsen

Anders Kiib @aekiib.bsky.social · 30/01/2025

I am excited to share that the latest project from the @tbpoulsen.bsky.social group, detailing the syntheses and biological evaluation of the four natural products cyclohelminthol I-IV is now available in Chemical Science! doi.org/10.1039/D4SC... A short "Bluetorial" below #ChemSky #ChemBio 1/7

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Reposted by Esben Svenningsen

Jacob Corn @jcornlab.bsky.social · 30/01/2025

Cells are filled with toxic stuff that damages healthy proteins. Is that garbage just left to rot on the curb? No way! Ubiquitin ligases have evolved to recognize chemical damage and clean it up! www.nature.com/articles/s41...

nature.com

C-terminal amides mark proteins for degradation via SCF–FBXO31 - Nature

SCF–FBXO31 scans proteins for C-terminal amidation and marks them for subsequent proteasomal degradation.

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Reposted by Esben Svenningsen

Thomas Tørring @thomastorring.bsky.social · 22/12/2024

A Christmas present to all of the lasso peptide connoisseurs out there. The next chapter in our work is on triculamin is ready on bioRxiv. Great work by two incredibly talented graduate students @amerrild.bsky.social and @tizianasvenningsen.bsky.social. www.biorxiv.org/content/10.1...

biorxiv.org

Convergent Evolution of the Antimycobacterial Lasso Peptide Triculamin

Triculamin is a ribosomally synthesized and post-translationally modified peptide (RiPP) lasso peptide with potent antimycobacterial activity, produced by an unusual, non-canonical biosynthetic gene c...

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Reposted by Esben Svenningsen

Sascha Hoogendoorn @hoogendoornlab.bsky.social · 03/12/2024

Job alert: fully funded postdoc position in chemical biology in beautiful Geneva! Do you have a PhD in Chemical Biology or related field with organic synthetic experience? Apply now! Details on how to apply can be found here: www.hoogendoornlab.org/joinus #chemsky #ChemBio

hoogendoornlab.org

Join us! | Hoogendoorn Lab

Openings for PhD students and postdocs will be advertized here

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Reposted by Esben Svenningsen

NFDI4Chem @nfdi4chem.de · 28/11/2024

Little Reminder: tomorrow 2pm. We are excited 😉

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Reposted by Esben Svenningsen

Yamuna Krishnan @krishnanyamuna.bsky.social · 26/11/2024

I want to write a paper titled “the sky is blue, the ocean is deep and trees are green”

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Esben Svenningsen @esbensv.bsky.social · 20/11/2024

In my first #bsky post, I am very happy and proud to share the new(ish) preprint of my post doc project on N-terminal cysteine (NCys) chemoprotomics using the oxSTEF probes! Preprint at 👉 www.doi.org/10.26434/chemrxiv-2024-4w549 Skeeturial (??) below ⬇️ #ChemSky #ChemBio

Graphical abstract of scientific paper. Chemical structures of oxSTEF probes and N-terminal cysteine, showing their reaction followed by a schematic of a proteomics experiment

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