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Joyce Ohm

@epigenohmics.bsky.social
986 followers 2.7K following 75 posts

Mostly I am just going to share cool sarcoma and epigenetics papers that I want to read 🧬🧪, with a sprinkling of the cutest dogs ever (mine🐶🐶) and maybe some food and 🏈!

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Reposted by Joyce Ohm
David Ho @davidho.bsky.social · 20/09/2026
Trump asked Russ Vought, OMB Director and the devil incarnate, to draft an executive order placing political appointees in charge of NIH grant funding, following the NIH director’s refusal to cut grants to Harvard.
politico.com
Trump asked budget chief to draft order bringing health research funding under his control
The move came after the NIH director refused Trump’s request to cut Harvard grants in an Oval Office meeting.
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Reposted by Joyce Ohm
foghornleghorn1357.bsky.social @foghornleghorn1357.bsky.social · 18/09/2026
Buffalo Bills Fans Sang O Canada Last Night And A Handful Of Fragile Americans Completely Lost Their Minds deanblundell.substack.com/p/buffalo-bi...
deanblundell.substack.com
Buffalo Bills Fans Sang O Canada Last Night And A Handful Of Fragile Americans Completely Lost Their Minds
Up to 20% of that crowd drives in from Ontario, and a few tough guys still got hurt by a 90 second song.
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Joyce Ohm @epigenohmics.bsky.social · 23/07/2026
We had a new friend visiting this morning on the honeysuckle. 😊#hummingbird vibes
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Joyce Ohm @epigenohmics.bsky.social · 16/07/2026
I sent everyone home. 🙁
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Joyce Ohm @epigenohmics.bsky.social · 29/06/2026
Don’t forget Inizio… 🤣
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Joyce Ohm @epigenohmics.bsky.social · 29/06/2026
So… I have a Rosie’s within walking distance… don’t hate me.
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Joyce Ohm @epigenohmics.bsky.social · 29/06/2026
Ice cream!
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Joyce Ohm @epigenohmics.bsky.social · 17/06/2026
You give me so much hope!
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Karim Wafa-Al Hussaini @karimwafa.bsky.social · 14/06/2026
Sharing this poem again because I think the world needs these words now more than ever.
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bioRxiv Cancer Bio @biorxiv-cancer.bsky.social · 05/06/2026
The RNA helicase DDX21 cooperates with ETS1 and FLI1 in cell cycle, immune evasion, and snoRNA processing in activated B-cell-like diffuse large B-cell lymphoma cells www.biorxiv.org/content/10.64898/20…
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Reposted by Joyce Ohm
Brilliance Proper @brillianceproper.com · 10/05/2026
Good morning Blacksky. Teach the babies to play instruments.
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Roswell Park Comprehensive Cancer Center @roswellpark.bsky.social · 20/04/2026
Celebrating an incredible achievement! 👏 Emily Isenhart, a predoctoral candidate in genetics, genomics and bioinformatics at Roswell Park, has been named one of Buffalo Business First’s 2026 30 Under 30 honorees. #30Under30 #FutureLeaders
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Reposted by Joyce Ohm
Harmit Singh Malik @harmitmalik.bsky.social · 19/04/2026
There needs to be a giant billboard in every major American city that touts this. In any other era except this suicidal science administration, this would be a miraculous, wondrous thing.
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Joyce Ohm @epigenohmics.bsky.social · 17/04/2026
This job is soul crushing. I’ve gotten plenty of NDs in my career. Got another one today. no big deal. Y’all are missing cool science. But hearing from a mentee, a promising physician/scientist with a 6% K08 being told that it is outside the fundable range today? What is even the f’ing point? SMH
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Reposted by Joyce Ohm
WeRateDogs @weratedogs.com · 13/04/2026
This is Sadie. She was finally reunited with her human, astronaut Christina Koch, after her mom’s voyage around the moon took her the furthest any human has ever been from their dog. She can't wait to hear all about the universe. 14/10 (IG: astro_christina)
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Jason Shepherd @jasonsynaptic.bsky.social · 10/04/2026
It’s brutal in academia right now. A lot is out of our control, but it doesn’t cost anything to remember that there are humans behind papers and grants…reviewers, program officials and funders can be more empathetic in the face of unprecedented chaos in the US scientific enterprise.
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Blue Wave @votebiue.bsky.social · 05/04/2026
Closeup of our Earth & Moon !
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Joyce Ohm @epigenohmics.bsky.social · 03/04/2026
Mentoring 101: if you are a faculty member on a graduate student thesis committee and you find yourself talking about the student instead of to the student about a concern. You don’t belong on that thesis committee (or probably any thesis committee.)
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Reposted by Joyce Ohm
Jeremy Berg @jeremymberg.bsky.social · 26/03/2026
My NIH update Let me start by saying again how glad I am that NIH is now posting these curves on the Reporter front page. It is satisfying that leading by example from outside has led to this change and (I hope) reflects a commitment for NIH_leadership™ to hold itself accountable for this. 1/6
A graph from the from page of the NIH Reporter website showing the number of extramural awards award by month for fiscal years 2022-2026. The curve for fiscal year 2026 lies below the other curves.
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Joyce Ohm @epigenohmics.bsky.social · 18/03/2026
Laughing… oh… I do know what meeting that was. 🤣🤣🤣🤣🤣👎
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Joyce Ohm @epigenohmics.bsky.social · 18/03/2026
WTH is going on in Pharmacology to bring on so much angst? Come downstairs. We’re a lot more chill in genetics. 🧬
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Joyce Ohm @epigenohmics.bsky.social · 10/03/2026
I sometimes wish people would yell at my faculty meetings. Too quiet. 🙁
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Mike Feigin 🥯 @mikefeigin.bsky.social · 06/03/2026
Buffalo Stand Up for Science speaker announcement: Dr Joyce Ohm! Meet the star of a recent Super Bowl commercial, a department chair, great scientist, and fantastic mentor! (I can’t find a picture of her speaking last year, so here’s Ethan.) @epigenohmics.bsky.social @standupforscience.bsky.social
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Joyce Ohm @epigenohmics.bsky.social · 06/03/2026
Plus my Resist sweatshirt is really cool!
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Joyce Ohm @epigenohmics.bsky.social · 06/03/2026
And probably pouring! 🌧️ 🤣
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Joyce Ohm @epigenohmics.bsky.social · 06/03/2026
I am the definition of resistance. I hope my resist sweatshirt is clean for tomorrow!
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Mike Feigin 🥯 @mikefeigin.bsky.social · 03/03/2026
Join us in Buffalo to take back our science, health and democracy! March 7th, 1-3PM, Niagara Square! Outstanding speakers including local scientists, politicians, and activists (details at the link)! fight2win.standupforscience.net/Buffalo-March/ @standupforscience.bsky.social
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Joyce Ohm @epigenohmics.bsky.social · 28/02/2026
Wise guys is excellent! Great first choice.
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Joyce Ohm @epigenohmics.bsky.social · 27/01/2026
Worst possible choice. So stupid.
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Joyce Ohm @epigenohmics.bsky.social · 18/01/2026
This… this right here is breaking my brain.
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Joyce Ohm @epigenohmics.bsky.social · 28/12/2025
This aged well! 💙❤️💙
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Roswell Park Comprehensive Cancer Center @roswellpark.bsky.social · 18/12/2025
🚨 𝗕𝗿𝗲𝗮𝗸𝘁𝗵𝗿𝗼𝘂𝗴𝗵 𝗶𝗻 𝗖𝗔𝗥 𝗧-𝗰𝗲𝗹𝗹 𝘁𝗵𝗲𝗿𝗮𝗽𝘆! Roswell Park researchers have developed IL-36 gamma “armored” CAR T cells that reprogram neutrophils to attack solid tumors. 🔗Read the full press release here: roswellpark.org/newsroom/202... #CARTCells #RoswellPark
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Joyce Ohm @epigenohmics.bsky.social · 14/12/2025
Send them to our mini lending library on the 2nd floor. Lots of good selections there including several recommended here!
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JAMA @jama.com · 27/10/2025
2025 Albert Lasker Basic Medical Research Award winner Steven McKnight describes discoveries that exposed the structures and functions of low-complexity domains within protein sequences. ja.ma/4hoxpRg
A JAMA viewpoint article titled, "The Enigma of Protein Domains of Low-Sequence Complexity" by Steven L. McKnight, PhD, discussing the 2025 Albert Lasker Basic Medical Research Award and discoveries related to protein structures.
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Magdalena Skipper @magdalenaskipper.bsky.social · 20/10/2025
“I believe he has ideas about becoming a scientist; on his present showing, this is quite ridiculous.” A privilege to have known John. He always listened to what one had to say with great intent. If you knew him, you know what I mean. 🧪 www.nature.com/articles/d41...
nature.com
John Gurdon obituary: Biologist who made cloning possible
He showed that specialized cells retain the genes to form an organism.
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Joyce Ohm @epigenohmics.bsky.social · 03/10/2025
I wrote a really cool grant this week.
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Reposted by Joyce Ohm
Nicole Rust @nicolecrust.bsky.social · 01/10/2025
Wise cartoon posted outside a @princetonneuro.bsky.social PhD student office. Let’s all remember to enjoy the journey today (and all days).
Cartoon showing a stick figure looking toward an end goal w/ a bumpy path to it.
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Reposted by Joyce Ohm
Barbara Marte @barbmarte.bsky.social · 26/09/2025
new out in Nature www.nature.com/articles/s41...
nature.com
In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma - Nature
In vivo loss-of-function CRISPR screens were performed to identify genes influencing CAR T cell persistence and function in human multiple myeloma, highlighting CDKN1B as a promising target.
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Reposted by Joyce Ohm
Graham Dellaire @docdellaire.bsky.social · 26/09/2025
📣 CRISPR had its day... meet Bridge RNA recombinases from the brilliant Patrick Hsu lab - 3rd Generation Gene Editing is HERE! 🔥🔥🔥🔥🔥🔥🔥 www.science.org/doi/10.1126/...
science.org
Megabase-scale human genome rearrangement with programmable bridge recombinases
Bridge recombinases are naturally occurring RNA-guided DNA recombinases that we previously demonstrated can programmably insert, excise, and invert DNA in vitro and in Escherichia coli. In this study,...
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Reposted by Joyce Ohm
Barbara Marte @barbmarte.bsky.social · 06/09/2025
new out in Nature www.nature.com/articles/d41...
nature.com
Compression causes cancer cells to start spreading
The switch between proliferation and invasion is triggered by mechanical force.
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Joyce Ohm @epigenohmics.bsky.social · 24/08/2025
Look at this cute little guy! #lakelife
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Bonky @shesbonky.bsky.social · 05/08/2025
If you think a golden ballroom is more important than childhood cancer research… I have nothing left to say to you. Please unfollow me. #pediatriccancer #cancermom
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Joyce Ohm @epigenohmics.bsky.social · 03/08/2025
Congratulations. That is so exciting.
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Joyce Ohm @epigenohmics.bsky.social · 09/07/2025
Hmmm… so… 1/5 after a 40% budget cut and the starting point was already a 7% payline at NCI. So a payline somewhere around 0.8%? 🤣🤣🤣
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Joyce Ohm @epigenohmics.bsky.social · 09/07/2025
This sounds ominous. Do I even want to know?
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Di Jiang @dijiang319.bsky.social · 16/06/2025
🧬🧪 @science.org RNA transcripts regulate G-quadruplex landscapes through G-loop formation | Science www.science.org/doi/10.1126/... @puckknipscheer.bsky.social @simonelsasser.bsky.social + al. @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social #DNA #RNA #genome #G-quadruplex #G-loop
science.org
RNA transcripts regulate G-quadruplex landscapes through G-loop formation
G-quadruplexes (G4s) are prevalent DNA structures that regulate transcription but also threaten genome stability. How G4 dynamics are controlled remains poorly understood. Here, we report that RNA tra...
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Joyce Ohm @epigenohmics.bsky.social · 13/06/2025
I learned this week that my MPI prostate cancer disparities R01 will be terminated this September at the end of year 1. Sounds like they are killing the whole disparities NOFO it was awarded under. Sigh… I am not surprised. I just hate all of this.
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Joyce Ohm @epigenohmics.bsky.social · 06/06/2025
That’s fine, but it’s still Ohm’s law.
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Joyce Ohm @epigenohmics.bsky.social · 23/05/2025
Wow, 7% depressing. In other news, please check your compiled grants in ERA Commons. 129 pages of our P50 missing going between the final preview of submitted Grant in ASSIST to the compiled grant in Commons. No errors. Put in ticket. Fixed. Still 2 pages missing. The NIH is not alright. 🙁
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Lars Velten @larsplus.bsky.social · 21/05/2025
Out @nature.com: Clonal tracing with somatic epimutations 🧬 Single cell methylome encodes cell state & clonal identity 🔨 EPI-Clone reads out both (+mutations, +RNA) at scale 🩸 Clonal expansions of HSCs are universal from age 50, not driven by CH mutations doi.org/10.1038/s415... 🧵
doi.org
Clonal tracing with somatic epimutations reveals dynamics of blood ageing - Nature
The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell lineage tracing th...
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