Zinngrebe et al. propose that adipocyte immunity represents an underappreciated component of host defense, with adipocyte functions extending far beyond energy storage to pathogen sensing and antimicrobial activity. At pathogen entry sites, adipocytes provide local host defense to contain microbial infections and preserve tissue integrity.

A preprint by Martins, Blankehaus et al. highlights an important role for monocyte-derived macrophages in iron homeostasis and its control of systemic energy metabolism.

In this Review, Erez and colleagues examine the complex interactions among tumours, their microenvironment and the host, shaping a metabolic macroenvironment that drives cancer progression. They explo...