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mRNA display can survey vast peptide populations, but the chemical diversity available to selection remains largely constrained by translation. DNA-encoded libraries possess the complementary advantag...

Many biological proteins function by changing shape upon small-molecule binding. Here, we present a general strategy for designing de novo proteins that undergo small-molecule-induced conformational c...

WARF helps steward the cycle of innovation with a team that includes intellectual property, commercialization, investment and engagement professionals.

AbstractSplit-aptamer biosensors offer exceptionally low background by assembling only in the presence of a target analyte; however, their performance is f

Proximity labeling (PL) can identify endogenous proteins in specific subcellular regions. APEX2 (enhanced ascorbate peroxidase 2) enables PL with high…

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A “reverse translation” technique converts protein sequences into DNA, enabling unprecedented detection sensitivity.

SAVEMONEY is a computational tool that guides users to mix plasmids prior to nanopore sequencing, reducing the effective cost of whole-plasmid sequencing to below that of Sanger sequencing.

YouTube video by CAS, a division of the American Chemical Society

Photocatalytic hydrolysis offers a shortcut for renewable chemicals

Merck KGaA's non-pyrophoric butyllithium in poly(α-olefin) oil make BuLi stable to air and water

Conformational biasing (CB) is a rapid and streamlined computational method that uses contrastive scoring by inverse folding models to predict protein variants biased toward desired conformational sta...

Inventing the future from the atom up

4.8k words, 22 minute reading time

The stereoselective functionalization of C–H bonds represents a central challenge in modern organic synthesis. Despite decades of innovation in C–H activation chemistry, methods for Z-selective functi...

Copper is an essential element for sustaining life. However, disruptions in copper homeostasis underpin disease, as illustrated by cuproptosis, an emerging form of cell death resulting from aberrant a...

Aptamer-based biosensors offer several advantages for detecting small molecules, including chemical stability and compatibility with diverse sensing formats. However, developing highly specific DNA ap...

N-glycans on glycoRNAs prevent innate immune sensing of endogenous small RNAs, and the natural mechanism they use demonstrates how glycoRNAs exist on the cell surface and in the endosomal network with...

To support graduate students (M.S. and Ph.D.), within one year of degree completion, whose education and training were disrupted due to recent termination or cancellation of research grants. Funding w...

Some obsolete lab equipment is quickly replaced, while other items are stubbornly persistent. What modern tech will survive to the 2060s?

We present example assessments featuring spectroscopic unknown puzzles, where the solution to the puzzle is the outcome of a known chemical reaction. These spectroscopic exercises engage students in a substantially more authentic manner than the conventional structure elucidation puzzles that are ubiquitous in organic chemistry instruction. Students use the same information available to practicing organic chemists, i.e., the chemicals added to the reaction vessel and information regarding the intended reaction outcome, to support their interpretation of GC-MS, IR, and NMR data. This centers the purpose of spectroscopy and spectrometry on understanding chemical phenomena, often chemical reactions, rather than on solving inauthentic unknown puzzles which are not connected to a chemical phenomenon. We anticipate that repeated use of spectroscopy and spectrometry in this manner will communicate to students why organic chemists highly value these techniques and how they are used to construct knowledge in organic chemistry.