Our new preprint is on ChemRxiv. We combine mRNA display with DNA-encoded chemistry, using two successive residue-selective modifications recorded by DNA barcodes. The approach generated ~20 million nominal chemical structures and was demonstrated by selection against CAIX.
chemrxiv.org
DNA-Encoded Chemical Diversification of mRNA Display Libraries | ChemRxiv
mRNA display can survey vast peptide populations, but the chemical diversity available
to selection remains largely constrained by translation. DNA-encoded libraries possess
the complementary advantag...
