Mouse demyelination models are widely used to study myelin loss and repair in the central nervous system. Here, the authors use single-cell RNA sequencing to compare glial responses across mouse model...

Remyelination can restore neural function. Here, the authors characterize the drivers and limits of endogenous remyelination and explore a therapy that rescued remyelination deficits and accelerated n...

Protein kinase C modulation with bryostatin-1 enables innate immune cells in the central nervous system to promote myelin repair and regeneration.

Tripotential intermediate progenitor cells are responsible for the local production of GABAergic neurons, oligodendrocyte precursor cells and astrocytes in the human neocortex.

An international research team, including researchers at Karolinska Institutet, has mapped the genes expressed in the brain cells of people with multiple sclerosis (MS). The atlas, which is presented ...

Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...

Single-cell and single-nucleus genomics pave the way for a comprehensive understanding of the nervous system and its diverse cell populations. Realizing this...