Reposted by Ryan TownleyMariah 🇺🇸🦋🇺🇸🦋🇺🇸🦋 @mariahbrown.bsky.social · 11/08/2026Remembering Robin Williams on the anniversary of his passing. His humor, kindness, and incredible talent continue to touch our hearts and inspire us every day. (July 21, 1951 – August 11, 2014) 339103501853
Ryan Townley @drtfromkc.bsky.social · 23/06/2026Yep! Thank you. This is not good news for the 100% of patients that come through my clinic that notice their difficulty with remembering people’s names as they get older :) 110
Reposted by Ryan TownleyEric Topol @erictopol.bsky.social · 12/05/2026Personalized neoantigen vaccines vs cancer: we've seen benefits for pancreatic, renal and melanoma. Today initial, encouraging results vs glioblastoma in 9 patients with this deadly brain cancer www.nature.com/articles/s43...nature.comAdjuvant personalized multivalent neoantigen DNA vaccination for MGMT unmethylated glioblastoma: a phase 1 trial - Nature CancerJohanns and colleagues report the results (including safety, efficacy and immunogenicity) of a phase 1 clinical trial of a DNA-based personalized therapeutic cancer vaccine administered following surg... 217647
Reposted by Ryan Townleydriftglass @driftglass.bsky.social · 12/05/2026In his 2nd Inaugural, Abraham Lincoln delivered what might be the most devastating rebuttal to the Both Sides lie in history. "Both parties deprecated war but one of them would make war rather than let the nation survive, and the other would accept war rather than let it perish. And the war came." 91721390
Reposted by Ryan TownleyEd Hawkins @edhawkins.org · 08/05/2026Spiralling global temperatures (1850-2026) It is exactly 10 years since I first put this animated graphic of changes in global temperature online. #ClimateSpiral It instantly went viral. People watched it over and over again. It still offers the power to shock a decade on. 6726161499
Ryan Townley @drtfromkc.bsky.social · 08/10/2025October is Lewy Body Awareness month. Please see attached educational opportunity for both medical professionals and families this Saturday morning on Zoom: 030
Reposted by Ryan TownleyInsta Science @instascience.bsky.social · 06/08/2025Smart! Raven loves winning Tic Tac Toe. 387180112983
Reposted by Ryan TownleyEric Topol @erictopol.bsky.social · 04/08/2025One in 4 people carry one copy of the APOE4 allele, the strongest known genetic risk factor for Alzheimer's disease. We've just learned how that risk is mediated—the immune system erictopol.substack.com/p/our-braini... 526785
Reposted by Ryan TownleyWashU Medicine Knight ADRC @washumedadrc.bsky.social · 30/07/2025FIRST ON CNN: Dramatic lifestyle changes can fight early-stage Alzheimer’s, study says. Here’s how | CNN www.cnn.com/2025/07/...cnn.comFIRST ON CNN: Dramatic lifestyle changes can fight early-stage Alzheimer’s, study says. Here’s how | CNNAdopting intensive lifestyle changes can slow or stop progression of early-stage Alzheimer’s disease, according to a new study. 011
Reposted by Ryan TownleyEric Topol @erictopol.bsky.social · 23/07/2025What's the optimal number of steps of physical activity this is associated with multiple (9) favorable outcomes? The largest, systematic review of 57 studies, 35 cohorts. 7,000 steps is clinically meaningful, benefit also seen for 4,000 steps cf 2,000 steps thelancet.com/journals/lan...thelancet.comDaily steps and health outcomes in adults: a systematic review and dose-response meta-analysisAlthough 10 000 steps per day can still be a viable target for those who are more active, 7000 steps per day is associated with clinically meaningful improvements in health outcomes and might be a mor... 9399107
Reposted by Ryan TownleyJohn Green @johngreensbluesky.bsky.social · 22/06/2025I seriously think the Social Internet is 21st century cigarettes. Complete with secondary smoke causing a lot of harm in nonusers. 984421502
Ryan Townley @drtfromkc.bsky.social · 19/06/2025This fits with my theories here of dementia being a multiple hit hypothesis and structural changes over a decade before lay the groundwork for brain failure in the setting of cognitive/systemic stressors. 031
Ryan Townley @drtfromkc.bsky.social · 16/06/2025Amazing thread. Trump has shown us on countless occasions that he has no shame. It’s more troublesome that there are enough like minded individuals he has surrounded himself with to propagate this metastatic hate. 000
Reposted by Ryan TownleyGuy Kawasaki @guykawasaki.bsky.social · 04/06/2025“A society grows great when old men plant trees whose shade they know they shall never sit in.” — Greek proverb 322608389
Ryan Townley @drtfromkc.bsky.social · 22/05/2025Interesting. I prefer the hypothesis that APOE4 has more CAA and disrupts BBB enough that more drug gets into the CNS than those without APOE4. If we could accurately measure BBB integrity we could tweak doses to reduce side effects. Or we just wait for the transferrin shuttle version :) 110
Reposted by Ryan TownleyEric Topol @erictopol.bsky.social · 15/05/2025Astrocytes have long been conceived as passive support player cells in the brain. But today @science.org (via 3 reports) they got a big upgrade for their active role in neuromodulation and control of brain function www.science.org/doi/10.1126/... 526271
Reposted by Ryan TownleyAlzheimer's Association @alzassociation.bsky.social · 15/05/2025Read our full statement calling on Sec. Kennedy to stop spreading harmful Alzheimer’s myths: bit.ly/43dRIKw. 4/4bit.lyContrary to Clear, Verifiable Facts, Secretary Kennedy Continues to Repeat Harmful Myths About Alzheimer’s and Dementia ResearchThe Alzheimer's Association calls on HHS Secretary Kennedy to stop dangerous fabrications about the state of Alzheimer’s and dementia research. 13016
Reposted by Ryan TownleyDr. Rachel Zoffness @drzoffness.bsky.social · 14/05/2025🔥 Most important paper I've read all year🔥 👉 Injury/disease doesn't reliably predict pain 👉 Biomarkers alone can't explain pain 👉 PSYCHOSOCIAL factors reliably determine chronic pain 👉 Painful conditions can be predicted from the SYNERGY btwn bio + psychosocial factors www.nature.com/articles/s41...nature.comBiological markers and psychosocial factors predict chronic pain conditions - Nature Human BehaviourFillingim et al. show that biological and psychosocial factors jointly predict conditions associated with chronic pain. 35722
Ryan Townley @drtfromkc.bsky.social · 13/05/2025Exciting! I know uses/cost will vary for UK but we did put together two related CME pieces: Biomarker training: kuadrc.org/bhb-training For more comprehensive cognitive evals (putting ptau217 into greater context) see my series: PCP training: kuadrc.org/pcpguidebookkuadrc.orgKU Primary Care Brain Health Program Empowering Pr 021
Reposted by Ryan TownleyKai Ryssdal @kairyssdal.bsky.social · 10/05/2025I just really need everybody to understand that everything that’s happening in and to the global economy now (and all the businesses and people in it) is the entirely predictable result of the intentional decisions of one guy who doesn’t understand how the global economy works. 833254765601
Reposted by Ryan TownleyEric Topol @erictopol.bsky.social · 04/05/2025The gylmphatics of our brain, which clear waste products, interact with our immune system and are key to preserving brain health, modulating its aging process, and propensity for neurodegenerative diseases A superb review @cp-immunity.bsky.social @jonykipnis.bsky.social 822150
Reposted by Ryan TownleyCodify Baseball @codifybaseball.bsky.social · 30/04/2025Catch probability? You wouldn’t believe me. 1968995
Reposted by Ryan TownleyDr. Lucky Tran @luckytran.com · 28/04/2025Deaths from heart disease down 75%, that’s NIH. Deaths from stroke down 75%, that’s NIH. HIV/AIDS no longer a death sentence, that’s NIH. 99% of FDA approved drugs in the last decade, that’s NIH. Please show this video to anyone who doesn’t understand why the NIH is so important. 5650322378
Reposted by Ryan TownleyJames Fallows @jfallows.bsky.social · 22/04/2025Almost every line of this story would have been simply unbelievable a few months ago: —Pioneering cancer researcher; —*Arrested* at airport in Boston; —Now indefinite ICE detention in Louisiana; —"Crime": not declaring some frog-embryo samples for research. Read it. www.nbcnews.com/news/us-news...nbcnews.comNew images could change cancer diagnostics, but ICE detained the Harvard scientist who analyzes themWithout scientist Kseniia Petrova’s expertise, no one can fully unlock the data’s potential, putting crucial advancements in early cancer detection at risk. 7242906813512
Reposted by Ryan TownleyChris Kluwe @chriswarcraft.bsky.social · 20/04/2025Personally, I think it should be front page news for at least a month if a sitting US President is using falsified evidence to try and deny due process to a man who has committed no crime, but that’s just me 7825178111287
Reposted by Ryan TownleyKevin M. Kruse @kevinmkruse.bsky.social · 15/04/2025We've seen videos like this before, but usually when you see a tearful wife pleading with the kidnappers who have taken her husband, she's not talking to the U.S. president 182198164850
Ryan Townley @drtfromkc.bsky.social · 12/04/2025They aren’t looking hard enough 😂 The reluctance to diagnose DLB on its own, even when a patient meets full criteria, is baffling to me. I see it often as a 2nd/3rd opinion referral. Board certified in neurology (ABPN) and BNNP certified - behavioral neurology and neuropsychiatry = wide gap! 010
Ryan Townley @drtfromkc.bsky.social · 12/04/2025It’s diagnosed in our clinic: 1. Amnestic dementia with RBD and hallucinations +/- Parkinsonism 2. Multidomain dementia with DLB criteria and hippocampal atrophy 3. Biomarker positivity for AD/DLB ICD10: major neurocognitive disorder d/t multiple pathologies. Then list AD and DLB underneath 010
Reposted by Ryan TownleyNatalie Christie Peluso 🧠 @nataliepeluso.com · 09/04/2025“Inside that tiny speck is an entire architecture like an exquisite forest..." 🧠❤️ #neuroskyence www.theguardian.com/science/2025...theguardian.comUS scientists create most comprehensive circuit diagram of mammalian brainThe 3D map of a cubic millimetre of mouse brain reveals half a billion synapses and 5.4km of neuronal wiring 0298
Ryan Townley @drtfromkc.bsky.social · 08/04/2025Lifestyle matters!! KU has put together our LEAP (Lifestyle Enrichment for Alzheimer’s Prevention) www.kumc.edu/research/alz...kumc.eduLifestyle Empowerment for Alzheimer's Prevention (LEAP!)Small lifestyle changes in diet, exercise, sleep and other areas can positively influence your risk of Alzheimer's. 010
Reposted by Ryan Townleysouthpaw @nycsouthpaw.bsky.social · 07/04/2025The Fourth Circuit is famously succinct. storage.courtlistener.com/recap/gov.us... 300216025830
Reposted by Ryan TownleyPopehat @kenwhite.bsky.social · 03/04/2025The penguins are globalists and rich liberal elitists. Just look how they’re dressed. 1021737223
Reposted by Ryan TownleyIan Kremer @wolverinebear.bsky.social · 01/04/2025press.vib.beScientists create protein ‘seeds’ that trigger key pathological features of ALS and frontotemporal dementia28 March 2024, Leuven, Belgium — Accumulation of a protein called TDP-43 is a key feature of ALS and frontotemporal dementia. In a newly published... 082
Reposted by Ryan TownleyEric Topol @erictopol.bsky.social · 27/03/2025New @science.org Hedonic eating (eating for pleasure, not need) is mediated by dopamine neurons (in the brain ventral segmental area, VTA) and they are antagonized by GLP-1 drugs, such as semaglutide, leading to weight loss www.science.org/doi/10.1126/...science.orgHedonic eating is controlled by dopamine neurons that oppose GLP-1R satietyHedonic eating is defined as food consumption driven by palatability without physiological need. However, neural control of palatable food intake is poorly understood. We discovered that hedonic eatin... 11385109
Reposted by Ryan TownleyShannon Macauley @macauleylab.bsky.social · 27/03/2025A great write up on our recent work in PNAS attempting to understand metabolic drivers of sleep, led by @ncons95.bsky.social ! uknow.uky.edu/research/fue...uknow.uky.eduFueling sleep: UK researchers show key metabolic link to restful nightsScientists have long recognized the brain’s need for energy, but groundbreaking research from the University of Kentucky’s Sanders-Brown Center on Aging has now illuminated how the brain’s energy uti... 03411
Reposted by Ryan TownleyScience Friday @scifri.bsky.social · 20/03/2025Researchers found 14 of the 20 amino acids essential for life on Earth in samples from the ancient asteroid Bennu.sciencefriday.comBuilding Blocks Of Life Found On Asteroid BennuEarly analysis of asteroid samples from NASA’s OSIRIS-REx mission show the residue of an icy brine, and a soup of amino acids. 361029163
Ryan Townley @drtfromkc.bsky.social · 17/03/2025Elon Musk as Wile E Coyote running into an ACME wall is too on the nose 110
Reposted by Ryan TownleyEric Topol @erictopol.bsky.social · 14/03/2025On the cyclic benefits of intermittent fasting and metabolic switching, this is an outstanding new perspective @naturemetabolism.bsky.social www.nature.com/articles/s42... 1222042
Reposted by Ryan TownleyDocAtCDI @docatcdi.com · 12/03/2025About fifty years ago, NASA strapped a message in a bottle to a rocket and flung it into the deep dark It wasn’t supposed to go this far, but it did. Long past its mission, it’s still out there so far away now that a simple hello takes a day to reach it, and another day to hear if it says hello back 331639642
Reposted by Ryan TownleyAtul Gawande @agawande.bsky.social · 13/03/2025Nothing will kill more children than the ongoing decimation of CDC, NIH, and USAID work to lift vaccine uptake in the US and world. Child survival rose 75% in the last 50 years. Vaccines account for 40% of that. Measles vax alone was 60% of the benefit. www.thelancet.com/journals/lan...thelancet.comContribution of vaccination to improved survival and health: modelling 50 years of the Expanded Programme on ImmunizationSince 1974 substantial gains in childhood survival have occurred in every global region. We estimate that EPI has provided the single greatest contribution to improved infant survival over the past 50... 5135111679