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Ryan Townley

@drtfromkc.bsky.social
819 followers 950 following 62 posts

Girl dad x 3 👸 | Dog dad x 2 🐶| Cognitive & Behavioral Neurologist 🧠| Program Director 🎬| Leading clinical trials in AD, DLB, and FTD. 👨‍🔬🔬Unraveling the mysteries of the mind, one axon at a time.

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Reposted by Ryan Townley
Mariah 🇺🇸🦋🇺🇸🦋🇺🇸🦋 @mariahbrown.bsky.social · 11/08/2026
Remembering Robin Williams on the anniversary of his passing. His humor, kindness, and incredible talent continue to touch our hearts and inspire us every day. (July 21, 1951 – August 11, 2014)
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Ryan Townley @drtfromkc.bsky.social · 23/06/2026
Yep! Thank you. This is not good news for the 100% of patients that come through my clinic that notice their difficulty with remembering people’s names as they get older :)
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Ryan Townley @drtfromkc.bsky.social · 23/06/2026
The link appears to have forgotten its pathing
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Eric Topol @erictopol.bsky.social · 12/05/2026
Personalized neoantigen vaccines vs cancer: we've seen benefits for pancreatic, renal and melanoma. Today initial, encouraging results vs glioblastoma in 9 patients with this deadly brain cancer www.nature.com/articles/s43...
nature.com
Adjuvant personalized multivalent neoantigen DNA vaccination for MGMT unmethylated glioblastoma: a phase 1 trial - Nature Cancer
Johanns and colleagues report the results (including safety, efficacy and immunogenicity) of a phase 1 clinical trial of a DNA-based personalized therapeutic cancer vaccine administered following surg...
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driftglass @driftglass.bsky.social · 12/05/2026
In his 2nd Inaugural, Abraham Lincoln delivered what might be the most devastating rebuttal to the Both Sides lie in history. "Both parties deprecated war but one of them would make war rather than let the nation survive, and the other would accept war rather than let it perish. And the war came."
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Ed Hawkins @edhawkins.org · 08/05/2026
Spiralling global temperatures (1850-2026) It is exactly 10 years since I first put this animated graphic of changes in global temperature online. #ClimateSpiral It instantly went viral. People watched it over and over again. It still offers the power to shock a decade on.
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Ryan Townley @drtfromkc.bsky.social · 08/10/2025
October is Lewy Body Awareness month. Please see attached educational opportunity for both medical professionals and families this Saturday morning on Zoom:
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Insta Science @instascience.bsky.social · 06/08/2025
Smart! Raven loves winning Tic Tac Toe.
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Eric Topol @erictopol.bsky.social · 04/08/2025
One in 4 people carry one copy of the APOE4 allele, the strongest known genetic risk factor for Alzheimer's disease. We've just learned how that risk is mediated—the immune system erictopol.substack.com/p/our-braini...
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WashU Medicine Knight ADRC @washumedadrc.bsky.social · 30/07/2025
FIRST ON CNN: Dramatic lifestyle changes can fight early-stage Alzheimer’s, study says. Here’s how | CNN www.cnn.com/2025/07/...
cnn.com
FIRST ON CNN: Dramatic lifestyle changes can fight early-stage Alzheimer’s, study says. Here’s how | CNN
Adopting intensive lifestyle changes can slow or stop progression of early-stage Alzheimer’s disease, according to a new study.
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Eric Topol @erictopol.bsky.social · 23/07/2025
What's the optimal number of steps of physical activity this is associated with multiple (9) favorable outcomes? The largest, systematic review of 57 studies, 35 cohorts. 7,000 steps is clinically meaningful, benefit also seen for 4,000 steps cf 2,000 steps thelancet.com/journals/lan...
thelancet.com
Daily steps and health outcomes in adults: a systematic review and dose-response meta-analysis
Although 10 000 steps per day can still be a viable target for those who are more active, 7000 steps per day is associated with clinically meaningful improvements in health outcomes and might be a mor...
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John Green @johngreensbluesky.bsky.social · 22/06/2025
I seriously think the Social Internet is 21st century cigarettes. Complete with secondary smoke causing a lot of harm in nonusers.
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Ryan Townley @drtfromkc.bsky.social · 19/06/2025
This fits with my theories here of dementia being a multiple hit hypothesis and structural changes over a decade before lay the groundwork for brain failure in the setting of cognitive/systemic stressors.
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Ryan Townley @drtfromkc.bsky.social · 16/06/2025
Amazing thread. Trump has shown us on countless occasions that he has no shame. It’s more troublesome that there are enough like minded individuals he has surrounded himself with to propagate this metastatic hate.
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Guy Kawasaki @guykawasaki.bsky.social · 04/06/2025
“A society grows great when old men plant trees whose shade they know they shall never sit in.” — Greek proverb
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Ryan Townley @drtfromkc.bsky.social · 22/05/2025
Interesting. I prefer the hypothesis that APOE4 has more CAA and disrupts BBB enough that more drug gets into the CNS than those without APOE4. If we could accurately measure BBB integrity we could tweak doses to reduce side effects. Or we just wait for the transferrin shuttle version :)
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Ryan Townley @drtfromkc.bsky.social · 15/05/2025
Timeline cleanser
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Eric Topol @erictopol.bsky.social · 15/05/2025
Astrocytes have long been conceived as passive support player cells in the brain. But today @science.org (via 3 reports) they got a big upgrade for their active role in neuromodulation and control of brain function www.science.org/doi/10.1126/...
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Alzheimer's Association @alzassociation.bsky.social · 15/05/2025
Read our full statement calling on Sec. Kennedy to stop spreading harmful Alzheimer’s myths: bit.ly/43dRIKw. 4/4
bit.ly
Contrary to Clear, Verifiable Facts, Secretary Kennedy Continues to Repeat Harmful Myths About Alzheimer’s and Dementia Research
The Alzheimer's Association calls on HHS Secretary Kennedy to stop dangerous fabrications about the state of Alzheimer’s and dementia research.
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Dr. Rachel Zoffness @drzoffness.bsky.social · 14/05/2025
🔥 Most important paper I've read all year🔥 👉 Injury/disease doesn't reliably predict pain 👉 Biomarkers alone can't explain pain 👉 PSYCHOSOCIAL factors reliably determine chronic pain 👉 Painful conditions can be predicted from the SYNERGY btwn bio + psychosocial factors www.nature.com/articles/s41...
nature.com
Biological markers and psychosocial factors predict chronic pain conditions - Nature Human Behaviour
Fillingim et al. show that biological and psychosocial factors jointly predict conditions associated with chronic pain.
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Ryan Townley @drtfromkc.bsky.social · 13/05/2025
Exciting! I know uses/cost will vary for UK but we did put together two related CME pieces: Biomarker training: kuadrc.org/bhb-training For more comprehensive cognitive evals (putting ptau217 into greater context) see my series: PCP training: kuadrc.org/pcpguidebook
kuadrc.org
KU Primary Care Brain Health Program Empowering Pr
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Kai Ryssdal @kairyssdal.bsky.social · 10/05/2025
I just really need everybody to understand that everything that’s happening in and to the global economy now (and all the businesses and people in it) is the entirely predictable result of the intentional decisions of one guy who doesn’t understand how the global economy works.
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Ryan Townley @drtfromkc.bsky.social · 10/05/2025
Nightmare fuel
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Eric Topol @erictopol.bsky.social · 04/05/2025
The gylmphatics of our brain, which clear waste products, interact with our immune system and are key to preserving brain health, modulating its aging process, and propensity for neurodegenerative diseases A superb review @cp-immunity.bsky.social @jonykipnis.bsky.social
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Codify Baseball @codifybaseball.bsky.social · 30/04/2025
Catch probability? You wouldn’t believe me.
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Dr. Lucky Tran @luckytran.com · 28/04/2025
Deaths from heart disease down 75%, that’s NIH. Deaths from stroke down 75%, that’s NIH. HIV/AIDS no longer a death sentence, that’s NIH. 99% of FDA approved drugs in the last decade, that’s NIH. Please show this video to anyone who doesn’t understand why the NIH is so important.
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James Fallows @jfallows.bsky.social · 22/04/2025
Almost every line of this story would have been simply unbelievable a few months ago: —Pioneering cancer researcher; —*Arrested* at airport in Boston; —Now indefinite ICE detention in Louisiana; —"Crime": not declaring some frog-embryo samples for research. Read it. www.nbcnews.com/news/us-news...
nbcnews.com
New images could change cancer diagnostics, but ICE detained the Harvard scientist who analyzes them
Without scientist Kseniia Petrova’s expertise, no one can fully unlock the data’s potential, putting crucial advancements in early cancer detection at risk.
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Chris Kluwe @chriswarcraft.bsky.social · 20/04/2025
Personally, I think it should be front page news for at least a month if a sitting US President is using falsified evidence to try and deny due process to a man who has committed no crime, but that’s just me
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Kevin M. Kruse @kevinmkruse.bsky.social · 15/04/2025
We've seen videos like this before, but usually when you see a tearful wife pleading with the kidnappers who have taken her husband, she's not talking to the U.S. president
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Ryan Townley @drtfromkc.bsky.social · 12/04/2025
They aren’t looking hard enough 😂 The reluctance to diagnose DLB on its own, even when a patient meets full criteria, is baffling to me. I see it often as a 2nd/3rd opinion referral. Board certified in neurology (ABPN) and BNNP certified - behavioral neurology and neuropsychiatry = wide gap!
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Ryan Townley @drtfromkc.bsky.social · 12/04/2025
It’s diagnosed in our clinic: 1. Amnestic dementia with RBD and hallucinations +/- Parkinsonism 2. Multidomain dementia with DLB criteria and hippocampal atrophy 3. Biomarker positivity for AD/DLB ICD10: major neurocognitive disorder d/t multiple pathologies. Then list AD and DLB underneath
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Natalie Christie Peluso 🧠 @nataliepeluso.com · 09/04/2025
“Inside that tiny speck is an entire architecture like an exquisite forest..." 🧠❤️ #neuroskyence www.theguardian.com/science/2025...
theguardian.com
US scientists create most comprehensive circuit diagram of mammalian brain
The 3D map of a cubic millimetre of mouse brain reveals half a billion synapses and 5.4km of neuronal wiring
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Ryan Townley @drtfromkc.bsky.social · 08/04/2025
Lifestyle matters!! KU has put together our LEAP (Lifestyle Enrichment for Alzheimer’s Prevention) www.kumc.edu/research/alz...
kumc.edu
Lifestyle Empowerment for Alzheimer's Prevention (LEAP!)
Small lifestyle changes in diet, exercise, sleep and other areas can positively influence your risk of Alzheimer's.
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southpaw @nycsouthpaw.bsky.social · 07/04/2025
The Fourth Circuit is famously succinct. storage.courtlistener.com/recap/gov.us...
The United States Government has no legal authority to snatch a person who is lawfully present in the United States off the street and remove him from the country without due process. The Government's contention otherwise, and its argument that the federal courts are powerless to intervene, are unconscionable.
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Ryan Townley @drtfromkc.bsky.social · 05/04/2025
#corgi focus
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Popehat @kenwhite.bsky.social · 03/04/2025
The penguins are globalists and rich liberal elitists. Just look how they’re dressed.
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Ian Kremer @wolverinebear.bsky.social · 01/04/2025
press.vib.be
Scientists create protein ‘seeds’ that trigger key pathological features of ALS and frontotemporal dementia
28 March 2024, Leuven, Belgium — Accumulation of a protein called TDP-43 is a key feature of ALS and frontotemporal dementia. In a newly published...
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Ryan Townley @drtfromkc.bsky.social · 28/03/2025
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Eric Topol @erictopol.bsky.social · 27/03/2025
New @science.org Hedonic eating (eating for pleasure, not need) is mediated by dopamine neurons (in the brain ventral segmental area, VTA) and they are antagonized by GLP-1 drugs, such as semaglutide, leading to weight loss www.science.org/doi/10.1126/...
science.org
Hedonic eating is controlled by dopamine neurons that oppose GLP-1R satiety
Hedonic eating is defined as food consumption driven by palatability without physiological need. However, neural control of palatable food intake is poorly understood. We discovered that hedonic eatin...
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Ryan Townley @drtfromkc.bsky.social · 28/03/2025
Shouting it from the mountain tops:
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Shannon Macauley @macauleylab.bsky.social · 27/03/2025
A great write up on our recent work in PNAS attempting to understand metabolic drivers of sleep, led by @ncons95.bsky.social ! uknow.uky.edu/research/fue...
uknow.uky.edu
Fueling sleep: UK researchers show key metabolic link to restful nights
Scientists have long recognized the brain’s need for energy, but groundbreaking research from the University of Kentucky’s Sanders-Brown Center on Aging has now illuminated how the brain’s energy uti...
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Science Friday @scifri.bsky.social · 20/03/2025
Researchers found 14 of the 20 amino acids essential for life on Earth in samples from the ancient asteroid Bennu.
sciencefriday.com
Building Blocks Of Life Found On Asteroid Bennu
Early analysis of asteroid samples from NASA’s OSIRIS-REx mission show the residue of an icy brine, and a soup of amino acids.
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Ryan Townley @drtfromkc.bsky.social · 17/03/2025
bsky.app/profile/sant...
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Ryan Townley @drtfromkc.bsky.social · 17/03/2025
Elon Musk as Wile E Coyote running into an ACME wall is too on the nose
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Eric Topol @erictopol.bsky.social · 14/03/2025
On the cyclic benefits of intermittent fasting and metabolic switching, this is an outstanding new perspective @naturemetabolism.bsky.social www.nature.com/articles/s42...
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Ryan Townley @drtfromkc.bsky.social · 14/03/2025
*Screams into the void*
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DocAtCDI @docatcdi.com · 12/03/2025
About fifty years ago, NASA strapped a message in a bottle to a rocket and flung it into the deep dark It wasn’t supposed to go this far, but it did. Long past its mission, it’s still out there so far away now that a simple hello takes a day to reach it, and another day to hear if it says hello back
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Atul Gawande @agawande.bsky.social · 13/03/2025
Nothing will kill more children than the ongoing decimation of CDC, NIH, and USAID work to lift vaccine uptake in the US and world. Child survival rose 75% in the last 50 years. Vaccines account for 40% of that. Measles vax alone was 60% of the benefit. www.thelancet.com/journals/lan...
thelancet.com
Contribution of vaccination to improved survival and health: modelling 50 years of the Expanded Programme on Immunization
Since 1974 substantial gains in childhood survival have occurred in every global region. We estimate that EPI has provided the single greatest contribution to improved infant survival over the past 50...
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Kai Ryssdal @kairyssdal.bsky.social · 13/03/2025
Found some waste…
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