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Replies

Shannon Macauley @macauleylab.bsky.social · 22/05/2025

This is interesting. Suggests different anti-amyloid antibodies don’t bind different forms of abeta. Anti-amyloid antibody equilibrium binding to Aβ aggregates from human Alzheimer disease brain

#NeuroDegeneration preprints@prepub-neurodegen.bsky.social

Anti-amyloid antibody equilibrium binding to Aβ aggregates from human Alzheimer disease brain #NeuroDegeneration 🧪🧠 https://www.biorxiv.org/content/10.1101/2025.05.20.654902v1

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Ryan Townley @drtfromkc.bsky.social · 22/05/2025

Interesting. I prefer the hypothesis that APOE4 has more CAA and disrupts BBB enough that more drug gets into the CNS than those without APOE4. If we could accurately measure BBB integrity we could tweak doses to reduce side effects. Or we just wait for the transferrin shuttle version :)

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Andrew Stern @andrewmstern.bsky.social · 22/05/2025

Thanks guys. To be clear, I still favor that antibody directly binding to CAA could be a cause of ARIA. We just found that the difference in ARIA-E between lec and adu can’t be fully explained by differences in CAA preference.

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