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Senthil Kumar @drsenthil.bsky.social · 04/12/2025

Significant reduction in proteinuria with the C3 and C3b inhibitor pegcetacoplan in IC-MPGN and C3GN. I hope we get to use this drug in India some day!

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Cristina Popa @nephroseeker.medsky.social · 08/02/2025

🔥Hot Debate—"The "KDIGO BP Targets in CKD Are (Un)Achievable and (Un)Realistic with @hswapnil.medsky.social pro unbiased take #ISNWCN His job was to convince a full room of unbelievers in low BPs #NephSky

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Cristina Popa @nephroseeker.medsky.social · 08/02/2025

10/ We shouldn't be afraid of creatinine #ISNWCN #MedSky @scoca1.bsky.social made it very easy to understand: maybe attach this to every consult? @glaucomflecken.bsky.social

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Cristina Popa @nephroseeker.medsky.social · 08/02/2025

2/ It was so close... but there was a winner. Curious to see who won? #ISNWCN

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Senthil Kumar @drsenthil.bsky.social · 08/02/2025

Happy to receive a prize on IgA quiz by Kidney Kolumns from @isn-india.bsky.social at WCN 2025. Thank you 🙏Dr. Mayuri Trivedi, Dr. Shyam Bansal and Dr. Vineet Behera. #ISNWCN

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Senthil Kumar @drsenthil.bsky.social · 08/02/2025

Doctors shouldn't measure BP 😅 We suck at it. 🤐 There are quite significant pre-requisites for it. All trials did automated BP recording. @hswapnil.medsky.social #ISNWCN

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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 08/02/2025

Screening criteria per Endocrine society for PA Contrast with actual screening rates - summarized here pubmed.ncbi.nlm.nih.gov/36965825/ from @ajkd.bsky.social #ISNWCN #NephSky

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Senthil Kumar @drsenthil.bsky.social · 07/02/2025

@argaiz.bsky.social killing with his teaching skills. It was an amazing session on POCUS and VExUS 👏🔥. Thank you 🙏 #ISNWCN

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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 07/02/2025

This is the algorithm he prefers from a 2020 for biopsy and management www.kidney-international.org/article/S008... 2020 @kidneyint.bsky.social - looks #OpenAccess #ISNWCN #NephSky #Onconeph Watch this space for biomarkers I say 😎

Figure 4 Approach to immune checkpoint inhibitor (ICPI) nephrotoxicity.∗Treat the underlying disease. AKI, acute kidney injury; ATI, acute tubular injury; ATIN, acute tubulointerstitial nephritis; GN, glomerulonephritis; IrAE, immune-related adverse event; RBC, red blood cell; RTEC, renal tubular epithelial cell; WBC, white blood cell.

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Senthil Kumar @drsenthil.bsky.social · 07/02/2025

Eisei Sohara talking about importance of genetic testing in CKD. ➡️10-15% of so called ADPKD do not have family history yet have PKD1/2 mutation. ➡️ Other genes involved in PKD (IFT40, CFAP47). ➡️10% of dialysis patients with unknown cause actually have genetic cause. #ISNWCN

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Joel Topf @kidneyboy.bsky.social · 30/01/2025

And we need to play by local rules and those rules say, we need to repost rather than just like. It was okay to be a lurker on #MedTweeter, but here we have to embrace our inner extrovert. Repost rather than like to help build #MedSky

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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 24/01/2025

The excellent overview of IgA management and the upcoming @kdigo.org guidelines from Prof IgA himself, Dr Barratt youtu.be/OChs5BcTEGE?... #NephGR #NephSky

youtu.be

Updates to the KDIGO Guidelines for the treatment of IgA nephropathy, with Prof Jonathan Barratt

YouTube video by Ottawa Nephrology

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KDIGO @kdigo.org · 21/01/2025

1️⃣ We are pleased to announce the publication of the KDIGO 2025 ADPKD Guideline! This first-ever KDIGO guideline focused on a rare kidney disease provides practical tools to improve diagnosis, care, and treatment. Read the news release: kdigo.co/2025-ADPKD-G... #ADPKD

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Senthil Kumar @drsenthil.bsky.social · 21/01/2025

@askrenal.bsky.social #askrenal One of our DrNB final theory questions. Role of nephrologists to promote Donation after Brain Death (DBD) programme in the country.😕 All I could write was SoMe campaign, talks, posters etc. What would #NephSky and #MedSky add to it?

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Senthil Kumar @drsenthil.bsky.social · 21/01/2025

Alisporivir, an original antiviral (HepC) drug had shown to increase in mutant trimers in Alport's syndrome acc. to this paper. It's also a cyclosporin derivative binding to cyclophilin and not to calcineurin. This was a final DrNB theory question 😑 journals.lww.com/kidney360/fu...

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Vivek Jha @vjha.bsky.social · 04/01/2025

Good noon all, IJN: Year: 2025, Volume: 35, Issue: 1, January-February Issue of Indian Journal of Nephrology is live. Kindly follow the link: indianjnephrol.org/current-issue/ @arvindcanchi.bsky.social @priti899.bsky.social

indianjnephrol.org

2024 – A Year in Review - Indian Journal of Nephrology

[article]

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Senthil Kumar @drsenthil.bsky.social · 30/12/2024

#askrenal Why has @goKDIGO not released any transplant recipient guidelines since 2009? As per that, HCV needs to be treated with IFN, only if benefits outweigh risks! 🤷‍♂️ Of course, '2018 tx candidate' and '2022 HepC' guidelines mention DAA for treatment in transplant pts.

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Senthil Kumar @drsenthil.bsky.social · 12/12/2024

One request for the journals. Can we have the article downloaded in PDF format with title mentioning the title of the article or the first author name and not some PIIS123?

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Senthil Kumar @drsenthil.bsky.social · 10/12/2024

I guess the hype for Google's Willow is real. What do you think Willow and it's quantum computing can change in the medical field?

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Tony Breu @tonybreu.bsky.social · 31/12/2021

1/17 [Why] is furosemide susceptible to malabsorption from "gut edema"? When a patient with heart failure is hospitalized with congestion I often hear "let's use IV furosemide; they're probably not absorbing the PO." It's a comment unique to furosemide. But is it accurate?

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Senthil Kumar @drsenthil.bsky.social · 08/12/2024

👉20 - 30% Na reabsorption in TALH. 50% of that occurs paracellularly😮 ➖️NKCC2 probably inhibits paracellular reabsorption as well (Mg and Ca loss). ❓️But why didn't ROMK,the main channel responsible for paracellular reabsorption,inhibitors pick up? Still wondering if we can increase the arsenal.

Chapter 21 from Oxford Textbook of clinical nephrology

K reabsorption via NKCC2 gets secreted back into lumen ensuring K availability for NKCC2 function. Hence, it also keeps lumen electropositive, causing paracellular absorption of cations. Tight junctions are not permeable to anions, otherwise there will be secretion of it due to the electropositivity.

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Dr. Smita Divyaveer, MD, DM Nephrology @divyaveerssneph.bsky.social · 06/12/2024

A warm welcome to every one again in this #ECNeph session 🙏🙏🙏 Greetings from Chandigarh, one of the most planned cities of India ! Lets start with the discovery of Parvovirus B19! Latin word ‘parvus’ or ‘parvum’ means small or tiny @myadla.bsky.social @theisn.org #ECNeph #Nephtwitter #Nephsky

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Juan Carlos Q Vélez, MD @juancarlosqvelez.bsky.social · 05/12/2024

12/12 in conclusion, be bold, NE + Lasix works and does not throw pts back into HRS. Push the MAP up, diurese away.

media.tenor.com

a large body of water is coming down a dam wall

ALT: a large body of water is coming down a dam wall

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ISNkidneycare @theisn.org · 05/12/2024

Happening Tomorrow on Bluesky #NephSky Join us for the inaugural #ECNeph Discussion by @DivyaveerSS.bsky.social , moderation by @myadla.bsky.social An interesting post-transplant case!

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Senthil Kumar @drsenthil.bsky.social · 05/12/2024

The main transporter responsible for Na entry into cells is NHE3 in proximal tubular cells of kidney. The encoded gene is SLC9A3. SLC - SoLute Carrier. I couldn't figure out how the numbering of SLC was done. Is it by the order of discovery like interleukins or anything else?

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Senthil Kumar @drsenthil.bsky.social · 04/12/2024

While going through H indexes of various investigators, found a "shark profile" and his most cited article. 😉 scholar.google.com/scholar_url?...

scholar.google.com

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Nephrology Journal Club @nephjc.bsky.social · 04/12/2024

T3e #nephjc BPROAD, the largest BP trial in high-risk T2D (n=12,821), used attended office BP measurements like ACCORD and ESPRIT but shifted to home monitoring during COVID-19, unlike SPRINT's unattended approach Table made by @shahsonride.bsky.social

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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 02/12/2024

But if a spike in first 6 months, but then keeps going up throughout … 3/

Figure 2 Cumulative incidence plots of AKI (Panel A) and kidney failure (Panel B) in patients with IBD undergoing partial or total colectomy.

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Senthil Kumar @drsenthil.bsky.social · 29/11/2024

Fantastic thread 👏 Thirst is because of (begin underline) effective osmole, causing intracellular dehydration (end underline).

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Senthil Kumar @drsenthil.bsky.social · 25/11/2024

Wonderful results favouring urgent start APD vs HD for those on maintenance PD. I feel in a corporate setup in India, PD in general is costlier than HD unless enrolled in some scheme. So to convince based on cost is ruled out here 😞

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Senthil Kumar @drsenthil.bsky.social · 24/11/2024

So who all come under CKD G1 A1 class?

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WHO @who.int · 20/11/2024

We heard you and we are verified on Bluesky! Follow the World Health Organization here for public health updates.🎉

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c0nc0rdance @c0nc0rdance.bsky.social · 20/11/2024

The MOST ABUNDANT PROTEIN ON EARTH is probably the one that almost all life depends on. It makes up ~3% of the mass of every leaf & blade of grass on the planet: a total weight of 10^11 kg. Let's talk about Ribulose-1,5-bisphosphate carboxylase/oxygenase or 'RuBisCO'. www.pnas.org/doi/10.1073/...

pnas.org

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

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Rafe Meager (they/them) @economeager.bsky.social · 20/11/2024

someone needs to put this in a development economics lecture

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Praveen G @nephtales.bsky.social · 14/11/2024

Nephrology - is not for normal doctors but for exceptionally skilled physicians 😎 #nephsky from www.thelancet.com/journals/lan....

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Senthil Kumar @drsenthil.bsky.social · 14/11/2024

Going through the FLOW trial and found that apart from the white population, where it clearly favours semaglutide, for the rest of the ethnicities, 95%CI lie on both sides. Given that there were 231 Indian patients and Asian population also not giving conclusive results, how to go about it?

Subgroup analysis of primary endpoint in FLOW trial

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Senthil Kumar @drsenthil.bsky.social · 13/11/2024

A medical oncologist in a state run Indian hospital, who recently underwent aortic valve replacement and on anticoagulants, was stabbed in the neck by the patient's son due to alleged neglected treatment of his mother. He's taken for surgery, but is very critical. Hope the situation improves 😥

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Senthil Kumar @drsenthil.bsky.social · 13/11/2024

Steatorrhea with renal failure think about enteric oxalosis. Can anyone tell me the prevalence of renal failure in enteric oxalosis? My search couldn't pick up any figure. #Nephsky #Medsky

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Senthil Kumar @drsenthil.bsky.social · 12/11/2024

This bluesky gives the nostalgic Twitter feel...

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