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Senthil Kumar @drsenthil.bsky.social · 04/12/2025

Significant reduction in proteinuria with the C3 and C3b inhibitor pegcetacoplan in IC-MPGN and C3GN. I hope we get to use this drug in India some day!

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Cristina Popa @nephroseeker.medsky.social · 08/02/2025

🔥Hot Debate—"The "KDIGO BP Targets in CKD Are (Un)Achievable and (Un)Realistic with @hswapnil.medsky.social pro unbiased take #ISNWCN His job was to convince a full room of unbelievers in low BPs #NephSky

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Cristina Popa @nephroseeker.medsky.social · 08/02/2025

10/ We shouldn't be afraid of creatinine #ISNWCN #MedSky @scoca1.bsky.social made it very easy to understand: maybe attach this to every consult? @glaucomflecken.bsky.social

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Cristina Popa @nephroseeker.medsky.social · 08/02/2025

2/ It was so close... but there was a winner. Curious to see who won? #ISNWCN

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Senthil Kumar @drsenthil.bsky.social · 08/02/2025

Happy to receive a prize on IgA quiz by Kidney Kolumns from @isn-india.bsky.social at WCN 2025. Thank you 🙏Dr. Mayuri Trivedi, Dr. Shyam Bansal and Dr. Vineet Behera. #ISNWCN

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Senthil Kumar @drsenthil.bsky.social · 08/02/2025

Doctors shouldn't measure BP 😅 We suck at it. 🤐 There are quite significant pre-requisites for it. All trials did automated BP recording. @hswapnil.medsky.social #ISNWCN

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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 08/02/2025

Screening criteria per Endocrine society for PA Contrast with actual screening rates - summarized here pubmed.ncbi.nlm.nih.gov/36965825/ from @ajkd.bsky.social #ISNWCN #NephSky

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Senthil Kumar @drsenthil.bsky.social · 08/02/2025

10-20% variability in eGFR. 40-50% variability in Albuminuria. Make your clinical judgment accordingly.👌 #ISNWCN

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Senthil Kumar @drsenthil.bsky.social · 07/02/2025

@argaiz.bsky.social killing with his teaching skills. It was an amazing session on POCUS and VExUS 👏🔥. Thank you 🙏 #ISNWCN

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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 07/02/2025

This is the algorithm he prefers from a 2020 for biopsy and management www.kidney-international.org/article/S008... 2020 @kidneyint.bsky.social - looks #OpenAccess #ISNWCN #NephSky #Onconeph Watch this space for biomarkers I say 😎

Figure 4 Approach to immune checkpoint inhibitor (ICPI) nephrotoxicity.∗Treat the underlying disease. AKI, acute kidney injury; ATI, acute tubular injury; ATIN, acute tubulointerstitial nephritis; GN, glomerulonephritis; IrAE, immune-related adverse event; RBC, red blood cell; RTEC, renal tubular epithelial cell; WBC, white blood cell.

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Senthil Kumar @drsenthil.bsky.social · 07/02/2025

Eisei Sohara talking about importance of genetic testing in CKD. ➡️10-15% of so called ADPKD do not have family history yet have PKD1/2 mutation. ➡️ Other genes involved in PKD (IFT40, CFAP47). ➡️10% of dialysis patients with unknown cause actually have genetic cause. #ISNWCN

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Joel Topf @kidneyboy.bsky.social · 30/01/2025

And we need to play by local rules and those rules say, we need to repost rather than just like. It was okay to be a lurker on #MedTweeter, but here we have to embrace our inner extrovert. Repost rather than like to help build #MedSky

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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 24/01/2025

The excellent overview of IgA management and the upcoming @kdigo.org guidelines from Prof IgA himself, Dr Barratt youtu.be/OChs5BcTEGE?... #NephGR #NephSky

youtu.be

Updates to the KDIGO Guidelines for the treatment of IgA nephropathy, with Prof Jonathan Barratt

YouTube video by Ottawa Nephrology

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KDIGO @kdigo.org · 21/01/2025

1️⃣ We are pleased to announce the publication of the KDIGO 2025 ADPKD Guideline! This first-ever KDIGO guideline focused on a rare kidney disease provides practical tools to improve diagnosis, care, and treatment. Read the news release: kdigo.co/2025-ADPKD-G... #ADPKD

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Senthil Kumar @drsenthil.bsky.social · 21/01/2025

Some pivot is probably with ICUs and maybe neurgosurgical teams. So I also added a good rapport with them is also translational. 😜 Of course governments need to make a stronger push. Unless governmental action brings in with stronger effort, I'm not sure what as we nephrologists could do🤷

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Senthil Kumar @drsenthil.bsky.social · 21/01/2025

@askrenal.bsky.social #askrenal One of our DrNB final theory questions. Role of nephrologists to promote Donation after Brain Death (DBD) programme in the country.😕 All I could write was SoMe campaign, talks, posters etc. What would #NephSky and #MedSky add to it?

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Senthil Kumar @drsenthil.bsky.social · 21/01/2025

Tacrolimus search didn't show any result and only cyclosporin did. (I guess because of no binding to cyclophilin). Alisporivir binds only to cyclophilin and not to calcineurin, hence I assume doesn't have the immunosuppressive action.

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Senthil Kumar @drsenthil.bsky.social · 21/01/2025

On doing literature search, there were few reports mentioning improvements of proteinuria with cyclosporin but most were case reports. One observational study which studied immunosuppressants (+CysA) didn't show benefit. It will be interesting to see if it picks up further.

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Senthil Kumar @drsenthil.bsky.social · 21/01/2025

Alisporivir, an original antiviral (HepC) drug had shown to increase in mutant trimers in Alport's syndrome acc. to this paper. It's also a cyclosporin derivative binding to cyclophilin and not to calcineurin. This was a final DrNB theory question 😑 journals.lww.com/kidney360/fu...

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Senthil Kumar @drsenthil.bsky.social · 12/01/2025

This looks quite some time back. But I'm able to see all your posts.

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Senthil Kumar @drsenthil.bsky.social · 12/01/2025

Clearly seen. Is this some sorta prank?🙄

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Senthil Kumar @drsenthil.bsky.social · 11/01/2025

DIPAK. Lanreotide didn't help.

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Vivek Jha @vjha.bsky.social · 04/01/2025

Good noon all, IJN: Year: 2025, Volume: 35, Issue: 1, January-February Issue of Indian Journal of Nephrology is live. Kindly follow the link: indianjnephrol.org/current-issue/ @arvindcanchi.bsky.social @priti899.bsky.social

indianjnephrol.org

2024 – A Year in Review - Indian Journal of Nephrology

[article]

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Senthil Kumar @drsenthil.bsky.social · 11/01/2025

Unfortunately research in India is all about quantity and never about quality. Glad it has come out.

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Senthil Kumar @drsenthil.bsky.social · 03/01/2025

I'm guessing with Na at high N(141) and K at low N(3.8), definitely Aldosterone action is going high despite ACEi + ARB. So my strong guess is MRA should stop it's work, decrease proteinuria as well and probably would negate the need for dual AT blockers. Just a theoretical assumption sir.

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Senthil Kumar @drsenthil.bsky.social · 02/01/2025

What's surprising here is that Losartan is at 100 mg BD, Enalapril at 5 mg BD and Dapagliflozin at 5mg OD, yet the patient's K is just 3.8. So I would assume aldosterone breakthrough happening full blown, sir?

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Senthil Kumar @drsenthil.bsky.social · 30/12/2024

💯%. I just felt the lag is more here. 😅 But anyways point duly noted sir 👍

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Senthil Kumar @drsenthil.bsky.social · 30/12/2024

My bad. 😀 And yes sir. It gives in most of the important points.

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Senthil Kumar @drsenthil.bsky.social · 30/12/2024

#askrenal Why has @goKDIGO not released any transplant recipient guidelines since 2009? As per that, HCV needs to be treated with IFN, only if benefits outweigh risks! 🤷‍♂️ Of course, '2018 tx candidate' and '2022 HepC' guidelines mention DAA for treatment in transplant pts.

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Senthil Kumar @drsenthil.bsky.social · 12/12/2024

One request for the journals. Can we have the article downloaded in PDF format with title mentioning the title of the article or the first author name and not some PIIS123?

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Senthil Kumar @drsenthil.bsky.social · 10/12/2024

I guess the hype for Google's Willow is real. What do you think Willow and it's quantum computing can change in the medical field?

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Tony Breu @tonybreu.bsky.social · 31/12/2021

1/17 [Why] is furosemide susceptible to malabsorption from "gut edema"? When a patient with heart failure is hospitalized with congestion I often hear "let's use IV furosemide; they're probably not absorbing the PO." It's a comment unique to furosemide. But is it accurate?

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Senthil Kumar @drsenthil.bsky.social · 08/12/2024

👉20 - 30% Na reabsorption in TALH. 50% of that occurs paracellularly😮 ➖️NKCC2 probably inhibits paracellular reabsorption as well (Mg and Ca loss). ❓️But why didn't ROMK,the main channel responsible for paracellular reabsorption,inhibitors pick up? Still wondering if we can increase the arsenal.

Chapter 21 from Oxford Textbook of clinical nephrology

K reabsorption via NKCC2 gets secreted back into lumen ensuring K availability for NKCC2 function. Hence, it also keeps lumen electropositive, causing paracellular absorption of cations. Tight junctions are not permeable to anions, otherwise there will be secretion of it due to the electropositivity.

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Senthil Kumar @drsenthil.bsky.social · 08/12/2024

Interesting. Coming across the end cutting needle for the first time.

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Senthil Kumar @drsenthil.bsky.social · 07/12/2024

Need some verified profiles here to bring in the authenticity for crowd pulling.

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Dr. Smita Divyaveer, MD, DM Nephrology @divyaveerssneph.bsky.social · 06/12/2024

A warm welcome to every one again in this #ECNeph session 🙏🙏🙏 Greetings from Chandigarh, one of the most planned cities of India ! Lets start with the discovery of Parvovirus B19! Latin word ‘parvus’ or ‘parvum’ means small or tiny @myadla.bsky.social @theisn.org #ECNeph #Nephtwitter #Nephsky

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Senthil Kumar @drsenthil.bsky.social · 06/12/2024

Fantastic review of SLC9 family 👌 I did go through the individual channel naming according to the function. But my question is why SLC1 is High-affinity glutamate and neutral amino acid transporter family and SLC2 is GLUT family and not the other way round?

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Juan Carlos Q Vélez, MD @juancarlosqvelez.bsky.social · 05/12/2024

12/12 in conclusion, be bold, NE + Lasix works and does not throw pts back into HRS. Push the MAP up, diurese away.

media.tenor.com

a large body of water is coming down a dam wall

ALT: a large body of water is coming down a dam wall

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ISNkidneycare @theisn.org · 05/12/2024

Happening Tomorrow on Bluesky #NephSky Join us for the inaugural #ECNeph Discussion by @DivyaveerSS.bsky.social , moderation by @myadla.bsky.social An interesting post-transplant case!

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Senthil Kumar @drsenthil.bsky.social · 05/12/2024

The main transporter responsible for Na entry into cells is NHE3 in proximal tubular cells of kidney. The encoded gene is SLC9A3. SLC - SoLute Carrier. I couldn't figure out how the numbering of SLC was done. Is it by the order of discovery like interleukins or anything else?

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Senthil Kumar @drsenthil.bsky.social · 04/12/2024

While going through H indexes of various investigators, found a "shark profile" and his most cited article. 😉 scholar.google.com/scholar_url?...

scholar.google.com

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Senthil Kumar @drsenthil.bsky.social · 04/12/2024

16:26 - 19:05. Promptly explained about subgroup analysis. P values for interactions are somewhat useful and not foolproof. And not gonna overinterpret subgroups from now on 👍 Btw that was a fantastic talk, sir @hswapnil.bsky.social 👏 youtu.be/67M4uxZ8fR4?...

youtu.be

How to analyse a scientific article Dr Swapnil Hiremath

YouTube video by Mumbai Kidney Foundation (MumbaiKidneyFoundation)

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