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Reposted by Paul A. Welling, MD

APS Publications @apspublications.bsky.social · 31/08/2026

Function | Monday Insights ☕ Don't miss out. Subscribe for alerts today! ow.ly/LNzo50ZGHT3

Paul A. Welling, MD @pawellingmd.bsky.social · 15/07/2026

Our review sheds light on a hidden driver of hypertension: low dietary potassium & the kidney’s “potassium switch.” The switch regulates potassium balance with ancient, low-sodium diets; in today’s high-salt, low-potassium diet, it increases BP and cardiovascular risk www.nature.com/articles/s41...

nature.com

The kidney distal tubule potassium switch, modern diet and hypertension - Nature Reviews Nephrology

This Review focuses on the potassium switch signalling pathway and its regulation of urinary sodium excretion according to plasma potassium levels. Welling and colleagues examine how this pathway affe...

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Reposted by Paul A. Welling, MD

American Physiological Society @apsphysiology.bsky.social · 07/07/2026

🚨APS has submitted formal comments to the Office of Management and Budget urging it to withdraw proposed sweeping changes to the federal research grant funding process. More on the full comments and how to make your voice heard: ow.ly/AG8C50ZlbSP #FightForPhysiology #SciPol #Advocacy 🧪

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Reposted by Paul A. Welling, MD

anil oza @aniloza.bsky.social · 17/06/2026

A 20 year study on 2 NIH diversity programs in Science Advances shows they doubled undergrads' odds of getting a Ph.D. That is, before the funding for those programs and for the study itself was terminated last year: www.statnews.com/2026/06/17/n...

statnews.com

NIH diversity programs doubled undergraduates’ odds of getting a Ph.D., 20-year study finds

A new study found that two diversity-oriented programs supported by the NIH doubled the odds that an undergraduate would earn a Ph.D.

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Paul A. Welling, MD @pawellingmd.bsky.social · 15/06/2026

Call for a paradigm shift in dietary management of hypertension and associated cardiovascular-kidney disease. New evidence supports broadening the current approach, which focuses solely on sodium reduction, to place equal emphasis on increasing potassium intake. www.sciencedirect.com/science/arti...

sciencedirect.com

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Reposted by Paul A. Welling, MD

American Physiological Society @apsphysiology.bsky.social · 03/06/2026

The White House proposes sweeping changes to federal grant-making. APS Science Policy Director Rebecca Osthus discusses what’s at stake and how to make your voice be heard. Submit a comment by 7/13: ow.ly/bc7V50Z7kib #SciPol #Advocacy #FightForPhysiology 🧪

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Paul A. Welling, MD @pawellingmd.bsky.social · 03/06/2026

Five Alarm Fire on US Science. Please provide public comment.

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Reposted by Paul A. Welling, MD

Jeremy Berg @jeremymberg.bsky.social · 28/05/2026

This is a substantial power grab by OMB. Comment period starts tomorrow. Here are two relevant excerpts. 1/3

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Reposted by Paul A. Welling, MD

Jess Calarco @jessicacalarco.com · 29/05/2026

This is bad. Bad for researchers. Bad for science. Bad for universities. Bad for professional associations. For example: 1. Every award would be vetted by political appointees, who could overrule peer reviewers and deny the award if it doesn't advance the president's priorities. 1/🧵

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Reposted by Paul A. Welling, MD

American Physiological Society @apsphysiology.bsky.social · 12/05/2026

❓Did you know? #APS2027 will feature 80 Foundational Science Sessions submitted from APS members and our broader scientific community—will yours be one of them? We're accepting submissions now, but don't delay—the deadline is June 5: ow.ly/zz3n50YVjEL #WeArePhysiology #ProfDev

Speaker presenting at a physiology conference with a call for session proposals due June 5.

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Reposted by Paul A. Welling, MD

American Physiological Society @apsphysiology.bsky.social · 13/03/2026

This could truly be a game changer for the millions suffering from chronic pain. Join us April 24 at #APS2026 to hear about emerging research on the pathophysiology of chronic pain and how it could unlock therapeutic breakthroughs: ow.ly/wZZb50YpOwf #ChronicPain #WeArePhysiology 🧪

Presentation slide titled 'Unraveling Chronic Pain' for APS 2026 by Daniela Salvemini, PhD, and Arkady Khoutorsky, DVM, PhD.

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Reposted by Paul A. Welling, MD

Albert and Mary Lasker Foundation @laskerfdn.bsky.social · 30/01/2026

Are you a physician-scientist in training? Are you looking to connect with other trainees? We are proud to help sponsor two upcoming APSA Regional meetings: the South and Mid-Atlantic Regional meetings. 🧪 Find your meeting: www.physicianscientists.org/page/Re…

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Paul A. Welling, MD @pawellingmd.bsky.social · 30/01/2026

Early-Stage Investigator (ESIs) Resource Showcase Travel Awards to support ESI participation and attendance at the inaugural George M. O’Brien Kidney Resource Alliance (OKRA) Resource Showcase. To apply, complete the online application (okra.awardsplatform.com) by 022326.

okra.awardsplatform.com

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Reposted by Paul A. Welling, MD

Bruce Springsteen @brucespringsteen.net · 28/01/2026

I wrote this song on Saturday, recorded it yesterday and released it to you today in response to the state terror being visited on the city of Minneapolis. It’s dedicated to the people of Minneapolis, our innocent immigrant neighbors and in memory of Alex Pretti and Renee Good. Stay free

youtu.be

Bruce Springsteen - Streets Of Minneapolis (Official Audio)

YouTube video by Bruce Springsteen

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Reposted by Paul A. Welling, MD

Chris Murphy @chrismurphyct.bsky.social · 21/01/2026

I spent the morning at the San Antonio immigration court. It’s out of control. Crawling with ICE - arresting legal immigrants showing up for court appearances. I asked one officer who they are prioritizing. His answer: everyone. I need to share with you what I saw.

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Reposted by Paul A. Welling, MD

APS Publications @apspublications.bsky.social · 20/01/2026

Review article by Yuuta Imoto and Shigeki Watanabe "Beyond Clathrin: Decoding the Mechanism of Ultrafast Endocytosis" 🖱️https://ow.ly/evL150XY7S2 #UltrafastEndocytosis

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Reposted by Paul A. Welling, MD

Eric Topol @erictopol.bsky.social · 08/01/2026

Here's a summary of all the data that supports adding more red meat to your diet

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Paul A. Welling, MD @pawellingmd.bsky.social · 08/01/2026

Remarkable: a treatment-induced increase in plasma potassium levels led to a significantly lower risk of appropriate ICD therapy, unplanned hospitalization for arrhythmia or heart failure, or death from any cause than standard care.

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Reposted by Paul A. Welling, MD

American Physiological Society @apsphysiology.bsky.social · 07/01/2026

From unraveling chronic pain to exploring the body's sensing system, #APS2026 game changers feature some of the biggest topics in the life sciences. Don't miss top scientists from around the world as they discuss these vital issues. More: ow.ly/Clpz50XSBG9 #WeArePhysiology 🧪

Speaker addressing a large audience at the American Physiology Summit in a spacious, well-lit conference hall.

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Reposted by Paul A. Welling, MD

PKD Research Resource Consortium @pkdresearch.bsky.social · 06/01/2026

Did you miss the PKD RRC Monthly Scientific Roundtable for January 2026? No worries, the outstanding presentation by Vishal D. Patel, M.D., UTSWMC, is now available at www.pkd-rrc.org/pkd-rrc-mont... #endPKD #PolycysticKidneyDisease

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Reposted by Paul A. Welling, MD

APS Publications @apspublications.bsky.social · 05/12/2025

🌟 Call for Applications for Editor-in-Chief of AJP-Heart and Circ 🌟 We're looking for an engaging and dynamic Editor who will be actively involved in shaping the strategic direction of the journal. To submit your application ➡️ ow.ly/AkAp50XC57C American Physiological Society

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Reposted by Paul A. Welling, MD

APS Publications @apspublications.bsky.social · 04/12/2025

🌟 Call for Applications for Editor-in-Chief of Physiological Reviews🌟 We're looking for an engaging & dynamic Editor to actively commission Reviews from high impact authors across all areas of #physiology. ow.ly/2oSy50XC4Nb American Physiological Society

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Reposted by Paul A. Welling, MD

APS Publications @apspublications.bsky.social · 08/12/2025

Congrats to Diogo Manoel, et. al, for the #APSselect paper "Functional characterization and cAMP-mediated rescue of a novel truncating AVPR2 mutation causing nephrogenic diabetes insipidus" in @AJPEndoMetab @saraivalmr @saraivalab @sidramedicine ow.ly/c38u50XFNEc

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Reposted by Paul A. Welling, MD

ASN Publications @asnpublications.bsky.social · 04/12/2025

This #ASNJASN research explored how two transcription factors, Dmrt2 and Hmx2, influence the differentiation of intercalated cells in the kidney, which are crucial for acid-base balance. Read more: kidney.pub/JASN0885 #BasicScience

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Reposted by Paul A. Welling, MD

American Physiological Society @apsphysiology.bsky.social · 01/12/2025

Physiology provides the foundation every medical advancement depends on. Our Physiology: The Science Life Depends On campaign elevates awareness of physiology’s crucial role in science and advocates for sustained research funding. Learn more at fightforphysiology.org #FightForPhysiology🧪

Young child with brown hair looking sideways under text about the importance of physiology in science and life.

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Reposted by Paul A. Welling, MD

American Physiological Society @apsphysiology.bsky.social · 10/11/2025

ICYMI, last week we launched "Physiology: The Science Life Depends On," a campaign to champion the discipline and protect the science behind every breakthrough. Our goal: to reintroduce physiology to the world. Learn more and join the #FightForPhysiology: fightforphysiology.org 🧪

Portrait of an elderly person outdoors with text promoting progress in physiology science. The text reads The Science Life Depends On. Let's drive physiology forward.

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Reposted by Paul A. Welling, MD

American Physiological Society @apsphysiology.bsky.social · 06/11/2025

Today, APS is launching Physiology: The Science Life Depends On, a campaign to champion #physiology and protect the science behind every breakthrough. It's time to reintroduce physiology to the world, together. Join the #FightForPhysiology at fightforphysiology.org 🧪

A young child with brown hair looks off to the side with a thoughtful expression against a soft gray background. Above her, bold text reads: “The science life depends on. Let’s drive physiology forward.” The word “life” is written in colorful script, and “physiology” is underlined in pink.

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Reposted by Paul A. Welling, MD

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 31/10/2025

Is it not really TGF - and something else in the tubules? Fascinating Biomarker study in @ajkd.bsky.social from the EMPA-KIDNEY group www.ajkd.org/article/S027... cc @pranavgarimella.bsky.social #NephSky #RevengeOfTheTubules

Figure 1 Effect of empagliflozin versus placebo on study average concentration of urine biomarkers (indexed to urine creatinine). The MMRM model was adjusted for the prognostic variables specified in the minimized randomization algorithm (i.e., age, sex, prior diabetes, eGFR, uACR, and trial site region) in the same categories used in the minimization process, initial freezer storage temperature (-20°C versus below -20°C) and baseline log2-transformed urine biomarker-creatinine ratio. A weighted average of 2- and 18- month values proportional to the amount of time between visits was used to estimate the study average log2-transformed urine biomarker-to-creatinine ratio in each arm. Absolute values indicate geometric mean (approximate SE) creatinine-indexed urine biomarker concentration in the units specified. The size of the boxes represents the amount of information estimated.

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Reposted by Paul A. Welling, MD

ASN Publications @asnpublications.bsky.social · 28/10/2025

This #ASNCJASN original research identified ten plasma proteins associated with dietary potassium and CKD risk in a US adult population, highlighting mechanisms involving iron deposition, mitochondrial function, inflammation, and fibrosis. Read more: kidney.pub/CJASN0864 @pawellingmd.bsky.social

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Reposted by Paul A. Welling, MD

ASN Publications @asnpublications.bsky.social · 16/10/2025

A randomized controlled trial in #ASNJASN finds that adjuvant thiazide improved diuretic response more than loop dose increased in patients with acute heart failure and diuretic resistance. Read more: kidney.pub/JASN0887 @pawellingmd.bsky.social

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Reposted by Paul A. Welling, MD

NEJM.org @nejm.org · 15/10/2025

BaxHTN phase 3 trial: Aldosterone dysregulation is considered a key driver of hard-to-control hypertension. Research findings on baxdrostat, a highly selective, potent aldosterone synthase inhibitor, in hard-to-control hypertension are summarized in a new Quick Take video. nej.md/3KCsQGJ

A visual representation of the BaxHTN phase 3 trial, which evaluated baxdrostat, a highly selective, potent aldosterone synthase inhibitor, in patients with hard-to-control hypertension.

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Reposted by Paul A. Welling, MD

NEJM.org @nejm.org · 08/10/2025

In a national cohort of veterans, the 2024–2025 Covid-19 vaccine was linked to reduced risks of emergency department visits, hospitalizations, and deaths from Covid-19 across the overall cohort and in various subgroups. Full study results: nej.md/47anKdz #MedSky #IDSky

A graph showing the Covid-19–associated composite outcome over 180 days in the 2024–2025 vaccination season

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Reposted by Paul A. Welling, MD

American Physiological Society @apsphysiology.bsky.social · 01/10/2025

It's time! The #APS2026 abstract portal is open! Submit your best work through 12/3 and we'll see you in Minneapolis in April: ow.ly/EjFJ50X4p89 #WeArePhysiology 🧪

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Reposted by Paul A. Welling, MD

Vaughn Cooper @vscooper.micropopbio.org · 21/08/2025

Our Pitt Microbiology and Molecular Genetics department in the School of Medicine is recruiting.. Microbiologists! 🧫🦠🔬🧪 Please apply to join our faculty and enjoy these views 👀 while doing great science cfopitt.taleo.net/careersectio...

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Reposted by Paul A. Welling, MD

American Physiological Society @apsphysiology.bsky.social · 15/08/2025

#BornThis Day in 1896, Gerty Cori was the first American woman to receive the 1947 #NobelPrize in #Physiology or Medicine (with scientist-husband Carl). Their work: How the body metabolizes sugar. More from @jwaonline.bsky.social: ow.ly/7YBR50WFiWz #ISpyPhysiology 🧪

A woman in a lab coat holds up a test tube for examination while a man in a lab coat stands beside her. They are surrounded by glassware, beakers, and scientific equipment in a laboratory setting.

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Paul A. Welling, MD @pawellingmd.bsky.social · 14/08/2025

The George M. O’Brien Kidney Resource Alliance announces its 3rd Opportunity Pool Program, supporting pilot grants (up to a maximum of $50,000 total costs) that address scientific and technological gaps in kidney research and promote new collaborations. www.uab.edu/okra/funding...

uab.edu

OKRA Opportunity Pool Program - George M. O’Brien Kidney Resource Alliance

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Reposted by Paul A. Welling, MD

Mark Peifer (He, him) @peiferlabunc.bsky.social · 12/08/2025

NIH is considering changes in supporting publication costs--some ideas are quite radical and would endanger our ability to publish at all. I don't love the cots from the big for-profits but it does cost$ to run a journal. Please repost. Comment at: osp.od.nih.gov/comment-form....

Dear SDB Members,

NIH is planning to cap APC (Article Processing Charges) from grant funds for publications, starting in January 2026.

https://grants.nih.gov/grants/guide/notice-files/NOT-OD-25-138.html

Proposed Policy Options for Keeping Publication Costs Reasonable:

Option 1: Disallow all publication costs.
Option 2: Set a $2,000 limit on allowable costs per publication.
Option 3: Set a $2,000 limit on allowable costs per publication and allow up to $3,000 when peer reviewers are compensated.
Option 4: Set an 0.8% limit on the total amount of an award that can be spent on publication costs, up to $20,000. For example, $250,000 direct cost grant = $2,000 per year for publications.
Option 5: Set a $6,000 limit on both the per publication cost and the total amount of an award (0.8% up to $20k) that can be spent on publications.

The NIH is requesting comments by Sept 15.

It is also possible to contribute comments that are not about any of the 5 options.

Comments should be submitted electronically to the following webpage: https://osp.od.nih.gov/comment-form-maximizing-research-funds-by-limiting-allowable-publishing-costs/.

Responses are voluntary and may be submitted anonymously.

The SDB encourages you to submit your opinions on this important issue.

Best,
Richard Behringer
President, SDB

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Reposted by Paul A. Welling, MD

Edgar V. Lerma 🇵🇭 @edgarvlermamd.medsky.network · 10/08/2025

Urine sodium (Urine Na) levels post-saline infusion in differentiating non-edematous hyponatremia ca. 2025 #Nephpearls #NephSky 👉🏼 pubmed.ncbi.nlm.nih.gov/40775013/

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