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Senthil Kumar

@drsenthil.bsky.social

674 followers 618 following 56 posts

MBBS, DNB (Gen.Med.), MRCP (UK), DrNB (Neph.). Consultant nephrologist, Sree Abirami hospital, Coimbatore, India. Passion for internal medicine and love for nephrology. Always believe in "Live and let live"

Posts Replies Media

Senthil Kumar @drsenthil.bsky.social · 08/02/2025

Happy to receive a prize on IgA quiz by Kidney Kolumns from @isn-india.bsky.social at WCN 2025. Thank you 🙏Dr. Mayuri Trivedi, Dr. Shyam Bansal and Dr. Vineet Behera. #ISNWCN

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Senthil Kumar @drsenthil.bsky.social · 08/02/2025

Doctors shouldn't measure BP 😅 We suck at it. 🤐 There are quite significant pre-requisites for it. All trials did automated BP recording. @hswapnil.medsky.social #ISNWCN

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Senthil Kumar @drsenthil.bsky.social · 08/02/2025

@nephjc.bsky.social session is happening now. @hswapnil.medsky.social @nephromythri.bsky.social #ISNWCN

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Senthil Kumar @drsenthil.bsky.social · 08/02/2025

10-20% variability in eGFR. 40-50% variability in Albuminuria. Make your clinical judgment accordingly.👌 #ISNWCN

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Senthil Kumar @drsenthil.bsky.social · 07/02/2025

@argaiz.bsky.social killing with his teaching skills. It was an amazing session on POCUS and VExUS 👏🔥. Thank you 🙏 #ISNWCN

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Senthil Kumar @drsenthil.bsky.social · 07/02/2025

Eisei Sohara talking about importance of genetic testing in CKD. ➡️10-15% of so called ADPKD do not have family history yet have PKD1/2 mutation. ➡️ Other genes involved in PKD (IFT40, CFAP47). ➡️10% of dialysis patients with unknown cause actually have genetic cause. #ISNWCN

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Senthil Kumar @drsenthil.bsky.social · 21/01/2025

Alisporivir, an original antiviral (HepC) drug had shown to increase in mutant trimers in Alport's syndrome acc. to this paper. It's also a cyclosporin derivative binding to cyclophilin and not to calcineurin. This was a final DrNB theory question 😑 journals.lww.com/kidney360/fu...

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Senthil Kumar @drsenthil.bsky.social · 30/12/2024

My bad. 😀 And yes sir. It gives in most of the important points.

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Senthil Kumar @drsenthil.bsky.social · 08/12/2024

👉20 - 30% Na reabsorption in TALH. 50% of that occurs paracellularly😮 ➖️NKCC2 probably inhibits paracellular reabsorption as well (Mg and Ca loss). ❓️But why didn't ROMK,the main channel responsible for paracellular reabsorption,inhibitors pick up? Still wondering if we can increase the arsenal.

Chapter 21 from Oxford Textbook of clinical nephrology

K reabsorption via NKCC2 gets secreted back into lumen ensuring K availability for NKCC2 function. Hence, it also keeps lumen electropositive, causing paracellular absorption of cations. Tight junctions are not permeable to anions, otherwise there will be secretion of it due to the electropositivity.

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Senthil Kumar @drsenthil.bsky.social · 25/11/2024

So GFR >90 ml and ACR < 30 mg/g with with any one of the following criteria for >3 months are classified under G1 A1. So an ANCA vasculitis or LN with N renal fn and in remission or Bartter’s syndrome with N electrolytes at present are still classified as CKD G1 A1? #askrenal @askrenal.bsky.social

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Senthil Kumar @drsenthil.bsky.social · 14/11/2024

Going through the FLOW trial and found that apart from the white population, where it clearly favours semaglutide, for the rest of the ethnicities, 95%CI lie on both sides. Given that there were 231 Indian patients and Asian population also not giving conclusive results, how to go about it?

Subgroup analysis of primary endpoint in FLOW trial

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