Traditional precious metal catalysis benefits from well-characterized inner-sphere elementary steps in which a single complex binds and unites substrates at the metal center. By contrast, base metal c...

The vaccine from Merck and Moderna prevented melanoma recurrence in combination with Merck’s Keytruda

Biocatalysis has become an important part of synthetic chemistry, particularly in the pharmaceutical industry. It is therefore important for chemistry students to learn about biocatalysis in their pro...

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A rapidly unfolding Ebola crisis in the Democratic Republic of Congo is a reminder of the value of maintaining robust global disease surveillance and response systems — and the dire consequences of we...

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Historically, many compelling therapeutic targets have been accessible only by injectable biologic drugs. Macrocyclic peptides, such as the proprotein convertase subtilisin/kexin type 9 inhibitor enli...

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IDVYNSO is approved for adults with virologically suppressed HIV-1 with no history of virologic treatment failure and no known substitutions associated with resistance to doravirine IDVYNSO is the fir...

Controlled placement of branch points along carbon chains is a core capability in the synthesis of materials, agrochemicals, and pharmaceuticals. Metal hydride hydrogen atom transfer (MHAT) to alkenes...

Carbanions of phenylacetonitriles, benzyl sulfones, and dialkyl benzylphosphonates add nitroarenes at the ortho-position to the nitro group to form $$\sigma ^\mathrm{H}$$ σ H -adducts that, upon treat...

The vaccines are tailor-made to target each patient's unique cancer.