iiinova — where your digital self keeps evolving

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Rémi Fronzes @fronzeslab.bsky.social · 29/09/2026

CryoFIB SEM installed at the @bic-bordeaux.bsky.social 🍾🎉🍾🎉

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McGill University @mcgill.ca · 14/09/2026

Meet the Titan Krios 300 kV cryo-EM. 🔬 One of only 3 in Canada, this towering 4.5 m microscope reveals highly accurate structures of cells, proteins and more. A key tool for advancing medical research. 📷 Nature Index, Integrated Structural Biology Grenoble (ISBG)

A McGill researcher wearing a white lab coat operates a Titan Krios cryo-electron microscope in a laboratory. The instrument’s access door is open, revealing internal components, with a computer workstation visible in the background.

Close-up view of the internal components of a Titan Krios cryo-electron microscope. The image shows a complex assembly of metallic cylinders, cables, sensors, and electronic components mounted within the instrument’s chamber, illuminated by blue and white lighting.

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Ben Engel @cellarchlab.com · 08/09/2026

MemBrain v2 is on @natmethods.nature.com now? I never had a @biorxivpreprint.bsky.social with 164 citations before😅 ...Which is also to say: Thank you to the amazing #TeamTomo community, many of whom not only beta tested, but also contributed diverse training data. This one belongs to all of us! 🤗🔬🧪

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CNRS Biologie @cnrsbiologie.bsky.social · 07/09/2026

#ResultatScientifique🔎| L’attention adaptative au bruit : clé d’une segmentation robuste des microtubules en microscopie ✍️ @bouvraish.bsky.social 🔬 @igdrennes.bsky.social 👋 @cnrs-bretagneloire.bsky.social @rennesuniv.bsky.social buff.ly/EOhBolv

insb.cnrs.fr

L’attention adaptative au bruit : clé d’une segmentation robuste des microtubules en microscopie

Les 'squelette

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Institut Jacques Monod @ijmonod.bsky.social · 01/09/2026

📣Paris Cytoskeleton Day - Registrations are open! 📅 November, 24th 📍Institut Jacques Monod Abstract submission closes on 2 November Registration closes on 16 November 🔗 pcd2026.sciencesconf.org

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Denis Chrétien @dchretien.bsky.social · 28/08/2026

Oui bien sûr, on n'arrive pas à se débarrasser de Cheichette, donc on la garde 😆

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Denis Chrétien @dchretien.bsky.social · 28/08/2026

Huge congratulations to Céline @celine-callens.bsky.social for her outstanding work on this study! Now, we’re eagerly awaiting her PhD defense in November to present these findings—and, of course, the final publication! (3/3)

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Denis Chrétien @dchretien.bsky.social · 28/08/2026

These microtubules exhibit remarkable structural heterogeneity with varying protofilament and helical-start numbers (as heterogeneous as in vitro-assembled microtubules). Even more intriguing: they contain an internal scaffold which may confer enhanced rigidity to support their functions.

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Denis Chrétien @dchretien.bsky.social · 28/08/2026

Dear #CryoEM and #Microtubule enthusiasts, I’m thrilled to have been part of this exciting journey: www.biorxiv.org/content/10.6... We discovered and characterized a manchette-like microtubule machinery in Xenopus spermatids, likely involved in sperm reshaping and membrane reorganization. (1/3)

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Denis Chrétien @dchretien.bsky.social · 27/08/2026

It can be used for a 2D classification approach, and also to facilitate analysis of cryo-EM images of microtubules, with its companion TubuleJ. Any feedback will be welcomed. (2/2).

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Denis Chrétien @dchretien.bsky.social · 27/08/2026

Dear #Cryo-EM and #Microtubule lovers. TubulePy is online at github.com/dchretien35/... TubulePy allows calculation of microtubule protofilament skew angles (θ) and helical parameters for different protofilament numbers (N) and helical-start numbers (S). (1/2).

github.com

GitHub - dchretien35/TubulePy: TubulePy allows calculation of microtubule helical parameters to built models from PDB files.

TubulePy allows calculation of microtubule helical parameters to built models from PDB files. - dchretien35/TubulePy

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Denis Chrétien @dchretien.bsky.social · 16/08/2026

Thanks for advancing the field! It's very nice to make these softs at the disposal of the cryo-EM/Microtubule community ;-)

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Reposted by Denis Chrétien

EMBL Events @events.embl.org · 22/06/2026

#EESMicrotubules brought together an amazing community of microtubule researchers last week 🥼 Thank you to our wonderful participants, speakers, and organisers for 4 days of outstanding science and thought-provoking discussions! We hope to see you again at the next edition.

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Denis Chrétien @dchretien.bsky.social · 03/07/2026

In situ structural biology: bridging molecular mechanisms with system-wide approaches www.embl.org/about/info/c...

embl.org

In situ structural biology: bridging molecular mechanisms with system-wide approaches

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Direct Electron @directelectron.bsky.social · 02/07/2026

More throughput. More particles. More structures. On a JEOL CRYO ARM 300 II, Apollo sustained 1,820 movies/hour across a complete cryo-EM dataset—collecting over 500,000 particles and reconstructing apoferritin to 1.72 Å in a single afternoon. Read how: ow.ly/kEYn50ZjOFX

ow.ly

HIGH-THROUGHPUT CRYO-EM WITH APOLLO - Direct Electron

Up to 2,904 movies per hour and sustained 1,820 movies per hour, reconstructing apoferritin at 1.72 Å in a single afternoon.

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Reposted by Denis Chrétien

Lena Schindler @lena-schindler.bsky.social · 23/06/2026

I am thrilled to share my PhD work with @nicolettapetridou.bsky.social @embl.org: www.biorxiv.org/cgi/content/... A fun collaboration with Bernat Corominas-Murtra, Adrián Aguirre-Tamaral, @bart-smeets.bsky.social , Jef Vanghel and Tom Belpaire! Read the story in the comments below ⤵️

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Denis Chrétien @dchretien.bsky.social · 23/06/2026

Well done. But is GTP-tubulin in an expanded state at the tip of growing microtubules? Indeed, nobody knows 🤔

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Reposted by Denis Chrétien

GIS IBiSA @ibisa.net · 15/06/2026

La #plateforme TEM2C de l'UAR Biosit propose ses services en cryo-microscopie électronique, cryo-tomographie et cryo-CLEM pour la biologie structurale et cellulaire ➡️ www.ibisa.net/plateformes-... @cnrsbiologie.bsky.social @inserm.fr @rennesuniv.bsky.social

ibisa.net

Transmission electron microscopy, cryo and CLEM (TEM2C)

Approches intégrées de cryo-microscopie électronique, cryo-tomographie et cryo-CLEM pour la biologie structurale et cellulaire.

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Eugene Katrukha 🇺🇦 @ekatrukha.bsky.social · 31/03/2026

The new release of #BigVolumeBrowser (0.1.0) finally adds animation render functionality to it, plus some other navigation improvements and bug fixes. Here is a movie I've made for the microtubule network (via ExM) in different cell types. Contact me if you want it for educational/research purposes.

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Leah @hoxinsocks.bsky.social · 31/05/2026

I love us

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RCSB Protein Data Bank @rcsbpdb.bsky.social · 16/05/2026

Try this new online training game from Leandro F. Estrozi designed for newcomers in structural biology, with a focus on cryo-EM and cryo-ET map interpretation: rico.ibs.fr/helixplo...

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Christophe 🔬 Leterrier @christlet.bsky.social · 13/05/2026

Check the little video they made from the interview (with the “Rolex” Rave skateboards tee-shirt 😆)

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Denis Chrétien @dchretien.bsky.social · 13/05/2026

Congratulations, you undoublty deserve it!

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Reposted by Denis Chrétien

Royal Microscopical Society @royalmicrosoc.bsky.social · 12/05/2026

We are very pleased to announce Prof. Paul Guichard and Dr. Virginie Hamel @centriolelab.bsky.social as joint winners of the RMS Award for Light Microscopy 🔬 👏 🏅 Huge congratulations to both! Read more about Paul and Virginie's achievements: www.rms.org.uk/resource/pro...

Prof. Paul Guichard (left) and Dr. Virginie Hamel both pictured smiling against a plain background. Head and shoulders images.

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Denis Chrétien @dchretien.bsky.social · 12/05/2026

Great discovery from Manuel Thery, even the Musée d'Orsay has a cytoskeleton 😍

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Reposted by Denis Chrétien

Aryan Taheri @aryantaheri.bsky.social · 08/05/2026

How do #tubulin dimers assemble and disassemble to form the #microtubule #cytoskeleton? Our recent #cryo-EM structures, published in #ScienceAdvances, demonstrate the processes of tubulin biogenesis and degradation. Click on the video and link below to learn more! www.science.org/doi/10.1126/...

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Denis Chrétien @dchretien.bsky.social · 06/05/2026

You loved the A- and B-type lattices in microtubules? Discover the C- and D-types specific to the GTP-like state of tubulin during the talk of Matthieu Benoit, 8th May, 10:30 warwick.ac.uk/fac/sci/med/... #microtubule #tubulin #CryoEM

warwick.ac.uk

Motors and Filaments

Mechanochemistry of molecular motors and cytoskeletal filaments - a scientific meeting at the University of Warwick

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Denis Chrétien @dchretien.bsky.social · 06/05/2026

The full EMBO microtubule program is now online 🤩 Note the talk of Celine Callens from our lab presenting the discovery and structural characterization of internal proteins within Xenopus spermatid microtubules on Thursday, 10:40 😍 www.embl.org/about/info/c... #microtubule #CryoEM

embl.org

Microtubules: from atoms to complex systems

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Reposted by Denis Chrétien

SBCF @sbcf.bsky.social · 04/05/2026

Ready for #CellLaVie2026? Program & registration are live! Join us Oct 21–23, 2026 at Institut Pasteur, Paris, for multidisciplinary cell biology, imaging, talks, posters & outreach, w/ Manuel Théry's behind-the-scenes look at the Musée d’Orsay video-mapping project. www.atoutcom.com/cell-la-vie/

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Anne Straube @anne.mechanochemistry.org · 01/05/2026

Barely a week to go until our "Motors and Filaments" meeting. Programme is ready. Catering ordered. My 3d printer has been busy too: have a look into the mingle bingo and dinner quiz prizes box. tinyurl.com/mechanochemi...

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Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 30/04/2026

#ESR Faudra-t-il en arriver là pour financer la recherche ? youtu.be/x2XMfjfG2ug?...

youtu.be

ICM - Le strip-tease

YouTube video by Publicis Conseil

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Alex Merz 🇺🇸🇨🇦🇺🇦 @merz.bsky.social · 23/04/2026

Vaults are still among the most mysterious of all structures found in eukaryotes. This is extremely cool and unexpected.

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Quanta Magazine @quantamagazine.org · 20/04/2026

A powerful electrical motor propels bacteria in virtually every gut and puddle on Earth. After 50 years, it has finally been understood. @nattyover.bsky.social reports: www.quantamagazine.org/what-physica...

quantamagazine.org

What Physical ‘Life Force’ Turns Biology’s Wheels? | Quanta Magazine

The bacterial flagellar motor is finally understood after 50 years. In its workings, columnist Natalie Wolchover finds the essence of life.

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Bui Lab @McGill @builab.bsky.social · 12/04/2026

The cartwheel was first visualized ~70 years ago in the symbiont Trichonympha in the wood termite gut. We’ve discovered the cartwheel’s secret: a unique zigzag stacking of SAS-6 tetramers that facilitates the iconic 9-fold symmetry of cilia. #cellbiology #teamtomo #SAS6 #cartwheel

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Denis Chrétien @dchretien.bsky.social · 11/04/2026

This concept is based on one GTP analogue (GMPCPP), and a GTP hydrolysis deficient recombinant version. But most other GTP/GDP-Pi analogues induce a compacted state of tubulin (GTPgS, BeF3-, AlF3-) similar to that of GDP-tubulin in microtubules. Let's humbly recognise that this issue remains 'open'.

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Denis Chrétien @dchretien.bsky.social · 11/04/2026

A very nice study showing that there is no obvious relationship between tubulin compaction/expansion state and its nucleotide state. Indeed, there is no experimental data demonstrating that GTP-tubulin is expanded in the GTP-cap at microtubule growing ends.

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Caitie McCafferty @computingcaitie.bsky.social · 08/04/2026

I am excited to share our most recent work collaborating with @centriolelab.bsky.social and @stearnslab.bsky.social to look at the ciliary base of mammalian multiciliated cells w/ cryo-ET, XL/MS, and U-ExM www.biorxiv.org/content/10.6...

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Denis Chrétien @dchretien.bsky.social · 03/04/2026

Opening of our JEOL Cryo-ARM 200, 2 April 2026 :-) Don't hesitate to get in touch with us if you want nice cryo-EM and/or cryo-ET data ! biosit.univ-rennes.fr/en/tem2c #cryo-EM #microtubule

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Benoît Zuber @benoitzuber.bsky.social · 30/03/2026

New paper in Nature Communications: we identified ANTXR2 (CMG2) as the cellular receptor for C. perfringens NetF toxin, causing hemorrhagic enteritis in dogs and foals. ANTXR2 was previously known as the receptor for anthrax toxin PA. doi.org/10.1038/s414...

doi.org

Identification and structural characterization of anthrax toxin receptor 2 as the Clostridium perfringens NetF receptor - Nature Communications

This study identifies ANTXR2 as the cellular receptor for Clostridium perfringens toxin NetF and determines its structure bound to the toxin using cryo-EM, revealing a distinct lateral binding mechani...

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Leah Lavery @helloleahlavery.bsky.social · 23/03/2026

Congratulations to Dr. Julia Mahamid on receiving the 2026 Gottfried Wilhelm Leibniz Prize! 🎉 Her pioneering work in cryo-ET is reshaping our understanding of how molecular architecture drives cellular processes and disease. #teamtomo #LeibnizPrize #StructuralBiology #LifeSciences #Innovation

dfg.de

Julia Mahamid, Ph.D. – Gottfried Wilhelm Leibniz Prizewinner 2026

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Carter Lab @carter-lab.bsky.social · 24/03/2026

Excited to share our work on the structure and function of cytoplasmic lattices within mouse embryos. A collaborative effort with @niakanlab.bsky.social and work led by @kashishsingh.bsky.social and @inaharasimov.bsky.social . It is now out on BioRxiv: www.biorxiv.org/content/10.6...

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