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David E Sanin

@davidesanin.bsky.social
735 followers 530 following 44 posts

Assistant Professor at Johns Hopkins University and macrophage enthusiast! | he/him 🏳️‍🌈 Opinions are my own! linktr.ee/davidesanin

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Reposted by David E Sanin
Jaz @jaz.sh · 27/09/2026
Okay so I've built a new Atlas, this time it lets you explore the conversations on Bluesky over the past 7 days graphically. It should update every ~6 hours and help you navigate the information environment that exists on here. I've learned a LOT about what people do here today... atlas.jazco.dev
atlas.jazco.dev
Atlas
A living map of what Bluesky is talking about: the past week's conversations, grouped into topics and regions and rebuilt every six hours.
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David E Sanin @davidesanin.bsky.social · 30/04/2026
Immune cells are a little obsessed with specific foods! immunologyexplained.aai.org/news/immune-...
immunologyexplained.aai.org
Immune Cells Are Picky Eaters! - Immunology Explained
Understanding how the nutrients available affect immune cells can help save and improve lives—from fighting cancer to infectious disease.
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David E Sanin @davidesanin.bsky.social · 29/04/2026
Amazing!!! Macrophages taking little bites from living cells to maintain self-tolerance. Incredible study!!
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Reposted by David E Sanin
The American Association of Immunologists @aai.org · 29/04/2026
We are incredibly proud to announce that 5 AAI members have been elected to the U.S. National Academy of Sciences in recognition of their distinguished achievements in original immunological research. Join us in celebrating this prestigious honor! Learn more: ow.ly/x4jM50YS0kj.
Announcement honoring AAI members elected to the National Academy of Sciences with their names listed.
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David E Sanin @davidesanin.bsky.social · 25/04/2026
Mitochondrial dynamics in macrophages has not been clearly defined before. Super excited to read this!!!
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Reposted by David E Sanin
Jakub Nowosad @jakubnowosad.com · 22/04/2026
a5R brings the A5 pentagonal geospatial index to R. Equal-area pentagonal cells across 31 resolutions, encoded as 64-bit integers, with millimetre-level precision at the finest scale 🗺️ R package by Hugh Graham; a5 by Felix Palmer github.com/belian-earth... #rstats #rspatial #dggs
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David E Sanin @davidesanin.bsky.social · 17/04/2026
This is super cool. Proteins as templates for DNA synthesis. Goes to show how biology confounds are best efforts to apply rigid dogmas!! Protein-templated synthesis of dinucleotide repeat DNA by an antiphage reverse transcriptase | Science www.science.org/doi/10.1126/...
science.org
Science | AAAS
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David E Sanin @davidesanin.bsky.social · 10/04/2026
Cool paper showing a new moonlighting function of iNOS in macrophages! It apparently binds IRG1 in the mitochondria and NO-independently regulates itaconate production!! Pretty cool stuff! Need to dive into the details but curious if it holds in human macs! www.nature.com/articles/s42...
nature.com
iNOS modulates inflammatory responses in an NO-independent manner through direct interaction with IRG1 in mitochondria - Nature Metabolism
This study reveals a non-canonical immunomodulatory function for the enzyme iNOS, based on the direct interaction in mitochondria with the itaconate-producing protein IRG1, which limits itaconate production in mouse and human macrophages
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David E Sanin @davidesanin.bsky.social · 04/04/2026
Wow!
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Reposted by David E Sanin
Denis Wirtz @deniswirtz.bsky.social · 02/04/2026
We integrate H&E and IHC sections (CODA) to generate 3D immune maps of tumors and precancerous lesions in the human pancreas. CODA allows to map very large volumes of tumors at single-cell resolution. More here: www.cell.com/cell-press-b...
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Denis Wirtz @deniswirtz.bsky.social · 01/04/2026
Watch this great video that Dr. Ashley Kiemen has made. It shows how we use AI to map individual immune cells in the vicinity of precancerous lesions of the human pancreas (PanINs). More here: www.cell.com/cell-press-b...
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John Bistline @bistline.bsky.social · 01/04/2026
This is my favorite climate change chart. Japanese monks, aristocrats, and emperors kept meticulous records of cherry blossom festivals for 1,200 years and accidentally built the world's longest climate dataset.
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Reposted by David E Sanin
Stephen Collins @stephencollins.bsky.social · 28/03/2026
I think the clocks in UK go back tonight. Or forward. Not sure. Is it forward
1 [Nurse talking to camera]
This is usually our busiest time of year at the centre 

2 [Show a sign outside a medical institution reading:]

Centre for Adults Who Still Can’t Get Their Heads Round Daylight Savings

3 
NURSE:
We have a spike in admissions when BST starts

4 
CONFUSED PATIENT BEING LAID DOWN BY NURSES:
Is it forward or back?

NURSE:
Lie down love

5 
We often see the same patients ever year

PATIENT:
So it’s like… time travel?

DOCTOR:
No

6 Every year we try to explain BST to them in a fun and memorable way

[The patients are sat around a fun show, with people dressed in bunny suits jumping around a giant clock] 

BUNNY: And now I *spring forward*...

7
[Bunny springs forward one hour on clock]

8 
PATIENT WATCHING SHOW:
I don’t get it

9 
The hardest patients are the Summer Time refusers

10 PATIENT [sat strapped to a chair as a doctor talks to him through a screen, through a tannoy]

PATIENT: But why is it better?

DOCTOR [talking through microphone]: 

Because it complicates things.

11 
PATIENT: 
How is that good?

DOCTOR: 
It makes you more tired.

12 

DOCTOR [to assistant]:
Fetch the cattle prod

[Ends]
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David E Sanin @davidesanin.bsky.social · 16/03/2026
A new pre-print from the lab!!! Check out SpotGraphs a simple little R package to explore spatial transcriptomics data using graph tools! www.biorxiv.org/content/10.6...
biorxiv.org
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Reposted by David E Sanin
James Briscoe @jamesbriscoe.bsky.social · 09/03/2026
New Perspective form Rory Maizels & me: "Gene regulatory networks: from correlative models to causal explanations" Gene regulatory networks are supposed to give us mechanistic explanations of development, so why are we drowning in 'hairballs' of statistical correlations? rdcu.be/e7zx7
rdcu.be
Gene regulatory networks: from correlative models to causal explanations
Nature Reviews Genetics - In this Perspective, Maizels and Briscoe discuss the limitations of current models of gene regulatory networks and outline solutions to harness data abundance without...
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David E Sanin @davidesanin.bsky.social · 20/02/2026
I'll be heading to IMMUNOLOGY2026™ from April 15–19, 2026!
i.snoball.it
Register for IMMUNOLOGY2026™ | April 15-19, 2026
The leading annual all-immunology event worldwide!
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David E Sanin @davidesanin.bsky.social · 11/02/2026
Context is everything in metabolism! This super elegant study on how hexokinase isoforms are conditionally essential depending on culture media and mitochondrial association highlights how much we need to work towards methods that let us probe these phenomena in vivo! rdcu.be/e3xOV
rdcu.be
Hexokinase detachment from mitochondria drives the Warburg effect to support compartmentalized ATP production
Nature Metabolism - Hexokinase detachment from the outer mitochondrial membrane is shown to support aerobic glycolysis in cancer cells. Differential localization of the HK1 isoform to the outer...
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David E Sanin @davidesanin.bsky.social · 11/02/2026
Metabolic control of immune cells impacts every aspect of their function. We show that monocytes transitioning to tissue resident macrophages need DHPS, otherwise monocytes are stalled in an immature state. Super excited to see this story published after a ton of work! rdcu.be/e3wKe
rdcu.be
The transition from monocyte to tissue-resident macrophage requires DHPS
Nature - In mice, DHPS supports the maturation, maintenance and function of tissue-resident macrophages via the polyamine–hypusine axis, with implications for macrophage-targeting therapies.
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David E Sanin @davidesanin.bsky.social · 11/02/2026
This is so cool!! Amazing work expanding single cell metabolomics to thousands of metabolites and hundreds of thousands of cells! Shame you need a custom built mass cytometer to do this 🥲 but hopefully someone is on this to make it widely accessible!
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David E Sanin @davidesanin.bsky.social · 08/02/2026
Looking forward to reading this!! Always fascinating how cells fine tune responses to common cytokines.
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Reposted by David E Sanin
Alan Dreams of Candy Corn @alans9.bsky.social · 13/01/2026
I can't say I'm surprised by this www.theguardian.com/environment/...
theguardian.com
‘A bombshell’: doubt cast on discovery of microplastics throughout human body
Exclusive: Some scientists say many detections are most likely error, with one high-profile study called a ‘joke’
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Chris Martine | Plant People FTW @martinebotany.bsky.social · 13/01/2026
Holy smokes
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Dr. Jean Fan @jef.works · 13/01/2026
I've seen some cool gesture-based point cloud controllers. So I noted the JS libraries used and vibe coded a similar web app to explore the relationship between spatial, UMAP, and PCA embeddings for spatial transcriptomics data. Next level interactivity via 🖐️ Try it out: jef.works/GestureGraph/
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Science News @scinews.bsky.social · 13/01/2026
All models are wrong, and yours is useless www.nature.com/articles/s41...
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David E Sanin @davidesanin.bsky.social · 12/01/2026
Super proud of Andrei Dorobantu who was named a @society4science.bsky.social #RegeneronSTS scholar for work that he performed in my lab. Only 300 young scientists are selected for this honor. bit.ly/4j6k8Oe
bit.ly
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Reposted by David E Sanin
Dr. Jean Fan @jef.works · 11/01/2026
Newfound disappointment: receiving shallow peer reviews that are entirely AI-generated. The whole point is critical feedback from YOU as a real expert. If reviewers are outsourcing to AI, I think we've lost the plot 🤷‍♀️ As an editor, I'm definitely keeping better track of reviewers I can trust...
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Reposted by David E Sanin
Johns Hopkins Data Science and AI Institute @hopkinsdsai.bsky.social · 19/12/2025
Join us in advancing data science and AI research! The Johns Hopkins Data Science and AI Institute Postdoctoral Fellowship Program is now accepting applications for the 2026–2027 academic year. Apply now! Deadline: Jan 23, 2026. Details and apply: apply.interfolio.com/179059
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Reposted by David E Sanin
Fabian Theis @fabiantheis.bsky.social · 15/12/2025
🚀 New preprint! The Human Cytokine Dictionary - 9.7M cells, 12 donors, 90 cytokines - our largest human single-cell perturbation atlas yet. Users can map cytokine activity in their own data. Huge thanks to Lukas, Sören, Larsen, Parse Bio & Seelig lab! 🔗 www.biorxiv.org/content/10.6...
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David E Sanin @davidesanin.bsky.social · 25/11/2025
Hot from the presses! Laura Sena's @laurasenamd.bsky.social team at at Johns Hopkins working hard to expand the toolkit to treat patients with prostate cancer! Super excited to see out: doi.org/10.1158/0008... This study was made possible by the support of the PCF @pcf-science.bsky.social
doi.org
Androgen receptor drives polyamine synthesis creating a vulnerability for prostate cancer
Abstract. Supraphysiological androgen (SPA) treatment can paradoxically restrict growth of castration-resistant prostate cancer with high androgen receptor (AR) activity, which is the basis for use of...
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David E Sanin @davidesanin.bsky.social · 17/11/2025
Excited to dig into this!!!
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Reposted by David E Sanin
Chris Marcum 📖 @csmarcum.sciences.social.ap.brid.gy · 13/11/2025
The Social Security Administration wants to share your data with the Department of Homeland Security. You might have something to say about that, and if you do, comment here: www.federalregister.gov/documents/2…
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Reposted by David E Sanin
Mark A. Hanson @hansonmark.bsky.social · 01/11/2025
Just tried q.e.d. by @odedrechavi.bsky.social et al. with a few papers including by myself & others where I knew a claim within was flawed based on a misunderstanding of the signal. 1) it was impressive. I see what the hype is about. 2) it hallucinated. www.qedscience.com Overly long #SciPub🧵 1/n
qedscience.com
q.e.d Science
Critical Thinking AI for constructive criticism and science evaluation
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David E Sanin @davidesanin.bsky.social · 22/08/2025
🚨 Want to find interesting cells in single-cell RNAseq data independently of clusters? Try our method to identify transcriptional shifts using OAR scores! Pre-print: doi.org/10.1101/2025... R tool and tutorials: sanin-lab.github.io/OARscRNA/ @biorxiv-bioinfo.bsky.social 1/n
doi.org
Missing data in single-cell transcriptomes reveals transcriptional shifts
Profiling thousands of single cell transcriptomes is routine, yet cell prioritization based on response to biological perturbations is challenging and confounded by clustering, normalization and dimen...
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David E Sanin @davidesanin.bsky.social · 20/07/2025
Interesting study showing macrophage gene regulation in response to cellular pH changes! www.cell.com/cell/fulltex...
cell.com
Regulation of inflammatory responses by pH-dependent transcriptional condensates
BRD4 functions as an intracellular pH sensor through a conserved histidine-rich intrinsically disordered region. Inflammation-associated acidification triggers a pH-dependent switch in transcriptional...
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Reposted by David E Sanin
Adam Braithwaite @braithwaiteat.bsky.social · 03/07/2025
Stimulating immune cells in vitro is a common experimental lab model. We profiled 150K blood immune cells treated with 11 different stimuli to compare the effects. The data are freely available for researchers. See the preprint for our findings and to access the data 🧪 doi.org/10.1101/2025...
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Jeffrey Keese @jeffreykeese.bsky.social · 21/06/2025
Meant to mention this last week, but if you have a young person in your life who’s into history or graphic novels or just good books, buy them George Takei’s “They Called Us Enemy.” My oldest couldn’t put it down.
Cover of George Takei’s They Called Us Enemy” showing a young Japanese American boy in a line of people being sent to an internment camp guarded by a uniformed American soldier
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Denis Wirtz @deniswirtz.bsky.social · 02/06/2025
Research Saves Lives At Hopkins, we just went live with an expansive website showing the extraordinary value of research, the impact of cuts to research, what's at stake, resources for our research community, etc. Check it out: researchsaveslives.jhu.edu
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David E Sanin @davidesanin.bsky.social · 29/05/2025
This is cool! Electron transport chain imbalance leading to RET and health complications, with evidence in human settings. www.nature.com/articles/s41...
nature.com
CoQ imbalance drives reverse electron transport to disrupt liver metabolism - Nature
Reverse electron transport is the mechanism behind excess mitochondrial reactive oxygen species in the livers of obese mice, which has implications for developing therapeutics for fatty liver dis...
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Reposted by David E Sanin
Denis Wirtz @deniswirtz.bsky.social · 28/05/2025
Dream Police alert: InterpolAI for enhanced 3D imaging (CODA, MRI, EM, confocal). Read about and InterpolAI here: www.nature.com/articles/s41...
nature.com
InterpolAI: deep learning-based optical flow interpolation and restoration of biomedical images for improved 3D tissue mapping
Nature Methods - InterpolAI leverages optimal flow-based artificial intelligence to produce synthetic images between pairs of images for diverse three-dimensional image types. InterpolAI is more...
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David E Sanin @davidesanin.bsky.social · 02/05/2025
This is WILD! 85% reduction in NAD+ and the tissue just functions as if nothing had happened!?! NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging: Cell Metabolism www.cell.com/cell-metabol...
cell.com
NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging
NAD depletion in skeletal muscle does not impair tissue integrity and function or accelerate aging, as shown in a mouse model with an 85% decrease in muscle NAD+ levels. Muscle structure, metabolism, ...
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Noam Teyssier @noamteyssier.bsky.social · 29/04/2025
Extracting @NCBI SRA files with fasterq-dump can require 17x the size of the accession while decompressing. Our new tool xsra extracts sequences at 5x throughput with significantly less disk usage, built-in compression, and optional BINSEQ outputs github.com/arcInstitute...
github.com
GitHub - ArcInstitute/xsra: An efficient CLI to extract sequences from the SRA
An efficient CLI to extract sequences from the SRA - ArcInstitute/xsra
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David E Sanin @davidesanin.bsky.social · 17/04/2025
The power of data!!! Dispassionately analyzed and meaningfully visualized!!! Just wow!! www.nytimes.com/interactive/...
nytimes.com
Opinion | To Understand Global Migration, You Have to See It First (Gift Article)
These estimates, drawn from the location data of three billion Facebook users, provide a view of human migration in extraordinary detail.
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Agnieszka Anna Pierwola @agnieszkaanna.bsky.social · 08/04/2025
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Denis Wirtz @deniswirtz.bsky.social · 04/04/2025
This integrated method shows how misleading traditional 2D assessments of immune cells localization in tissues is misleading. 3D assessments are a must.
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David E Sanin @davidesanin.bsky.social · 16/03/2025
Over the past few decades the world has collectively reduced poverty and disease at an outstanding rate! Collectively, we should continue doing that! There is no other moral position. www.nytimes.com/interactive/...
nytimes.com
Opinion | Musk Said No One Has Died Since Aid Was Cut. That Isn’t True. (Gift Article)
A journey through the front lines of global poverty shows that when the world’s richest men slash aid for the world’s poorest children, the result is sickness, starvation and death.
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Adam MacLean @adamlmaclean.bsky.social · 12/02/2025
Thanks to everyone for a fantastic meeting #SACB2025 @cancersysbio.bsky.social (I sure needed an injection of great science in *these times*) @mathcancer.bsky.social closing out the show...
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Krista Bledsoe @kristabledsoe.bsky.social · 12/02/2025
I'm co-organizing a Cell Symposia on Metabolites in Organellar Communication with @robzonculab.bsky.social, Kivanc Birsoy, and Allyson Evans (@cp-cellmetabolism.bsky.social). It will be in Sitges May 11-13. Submit an abstract by Feb 14. Hope to see you in Spain! cell-symposia.com/metabolites-...
cell-symposia.com
Home – Cell Symposia: Metabolites: organellar communication in health and disease
Cell Symposia: Metabolites: organellar communication in health and disease
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Association for Cancer Systems Biologists @cancersysbio.bsky.social · 11/02/2025
The #SACB2025 immunology session closes out with @davidesanin.bsky.social discussing myeloid cell regulation in prostrate cancer
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David E Sanin @davidesanin.bsky.social · 11/02/2025
Enjoying day one of #SACB2025! Amazing line up of speakers today!! Good reminder of the amazing communities of scientists using all kinds of tools and working towards helping patients with cancer!
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