For Peer Review Week 2026, we asked the Chefs two questions: What is one uncomfortable truth about peer review that the scholarly publishing community doesn’t talk about enough? And, beyond recruiting...

X-chromosome inactivation involves chromosome-wide gene silencing accompanied by extensive chromatin changes, as well the loss of topologically associating domains. Yet discrete regions of the inactiv...

Development depends on gene regulation by enhancers across long genomic distances. This Perspective discusses mechanisms enabling long-range enhancer–promoter communication and the potential advantage...

Tener 'superpoderes' no siempre es positivo y tampoco se asocia siempre a héroes que salvan el mundo. Se define como una habilidad o facultad extraordinaria, es decir, fuera de lo común, y es lo que ocurre con las células tumorales capaces de iniciar la metástasis. Patricia Altea (Sevilla, 1988), directora del grupo de Regulación Metabólica y Señalización en Cáncer del Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER) quiere descubrir porqué estas unidades concretas tienen dicha cualidad y junto con su equipo en el CABIMER investiga cómo funciona este proceso para cambiar el pronóstico de las pacientes con cáncer de mama. Ella fue la ganadora del premio a la mejor investigadora joven de los Premios Hipatia de elEconomista.es en su última edición.

Chromosome conformation analysis in Drosophila wing discs reveals the requirement of specific meta-loops during regeneration.

We show that, in a genomic locus with minimal complexity, the distance between promoter and enhancer modulates the frequency of clustered transcriptional bursts. Thus, besides the nucleotide sequence,...

Coral reefs depend on an intracellular symbiosis between cnidarian hosts and photosynthetic dinoflagellates that is disrupted by ocean warming, causing coral bleaching. Yet how these responses are dis...

Palikyras and colleagues investigate chromatin reorganization upon senescence induction, reporting that components of nuclear speckles coordinate chromatin rewiring and a senescence-associated splicin...

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The idea that cells remember past states to prepare their future endeavors has split into two parallel languages that rarely converse. On one side, chromatin epigenetics defines inheritance through th...

ALT: Bugs Bunny Says Thank You

Previously uncharacterized supporting-like cells are involved in testicular and ovarian development.

ALT: Bugs Bunny with Carrots and E. Coyote Sign

What should Europe do when demand for its most successful frontier research programme keeps rising? Restrict access, or invest in the excellence it has created? A new open letter, spearheaded by Sara...

The 2026 Gordon Research Conference on Mammalian Reproduction will be held in Newry, Maine. Apply today to reserve your spot.