A spatiotemporal atlas of the human meninges during early-to-mid gestation identifies asynchronous layer development and transcriptomic features of meningeal cells and demonstrates that pial fibroblas...

Astrocytes make up one-quarter of the brain, but researchers are only now realizing their true value.

The meninges, which envelop and protect the brain, host a large number of resident macrophages that play a crucial role in regulating homeostasis and neuroinflammation. Intracellular Ca2+ signaling me...

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Seeing stars – astrocytes in primary visual cortex drive migraine pain.

Functional imaging and multiplexed in situ hybridization were combined to investigate how trigeminal neurons encode heat and mechanical stimuli, revealing distinct cellular mechanisms for continuing p...

T cells have emerged as orchestrators of pain amplification, but the mechanism by which T cells control pain processing is unresolved. We found that regulatory T cells (Treg cells) could inhibit nocic...

Zhang et al. identify unimodal neural representations in the spinal cord of cutaneous mechanical and heat stimuli gated by a shared feed-forward local inhibitory neuron type and a neural transition du...

Itch is a dominant symptom in dermatitis, and scratching promotes cutaneous inflammation, thereby worsening disease. However, the mechanisms through which scratching exacerbates inflammation and wheth...