Yi Xiao @yixiao.bsky.social · 25/09/2026Super excited that part of my postdoc work is online now! 011
Reposted by Yi XiaoChildren's Research Institute at UT Southwestern @cri-utsw.bsky.social · 16/09/2026ONLINE NOW in @cellpress.bsky.social: McBrayer Lab's #relentlessdiscovery finds 100-fold accumulation of metabolite GAA overstimulates nearby neurons to fuel aggressive brain tumor growth. 🧪 Read more ⬇️ cri.utsw.edu/scientists-d...cri.utsw.eduScientists discover metabolite fueling aggressive brain tumor growth - Children's Medical Center Research Institute (CRI) | Dallas TexasStudy from McBrayer Lab shows brain tumors exploit metabolite to activate nearby neurons DALLAS – Sept. 15, 2026 – Virtually all high-grade, aggressive gliomas in adults accumulate massive amounts of ... 121
Reposted by Yi XiaoChildren's Research Institute at UT Southwestern @cri-utsw.bsky.social · 05/08/2026ONLINE NOW in @science.org Translational Medicine from CRI's McBrayer Lab: www.science.org/doi/10.1126/.... Full 🧵 in comments ⬇️ #relentlessdiscovery 🧪science.orgVorasidenib improves response to subsequent chemoradiation in a genetically engineered mouse model of IDH-mutant gliomaA genetic mouse model of IDH-mutant glioma responds to mutant IDH inhibitor (mIDHi) and shows that prior mIDHi treatment improves response to chemoradiation. 1133
Reposted by Yi XiaoChildren's Research Institute at UT Southwestern @cri-utsw.bsky.social · 16/07/2026ONLINE NOW in @science.org: Latest #relentlessdiscovery from CRI's McBrayer Lab uses their newly developed biosensor to track missing metabolite (αKG) in rare childhood brain disorder, GPT2 deficiency. 🧪 Read more ⬇️ cri.utsw.edu/new-biosenso...cri.utsw.eduNew biosensor tracks down missing metabolite from childhood brain disorder - Children's Medical Center Research Institute (CRI) | Dallas TexasScience study shows alpha-ketoglutarate supplementation may delay progression of GPT2 deficiency, rare inborn error of metabolism DALLAS – July 16, 2026 – Scientists at Children’s Medical Center Resea... 021
Reposted by Yi XiaoChildren's Research Institute at UT Southwestern @cri-utsw.bsky.social · 01/07/2026Here at CRI #relentlessdiscovery = #NeverChaseReality and McBrayer Lab is ready to cheer the #USMNT to the next round. Gooooooooal ⚽️🏆#StarsAndStripes #FIFAWorldCup #FWC26 #WeAre26 011
Reposted by Yi XiaoMilan Savani @milansavani.com · 29/04/20261/12 🛣️ Mapping nitrogen metabolism has lagged carbon due to substrate diversity. In @natmetabolism.nature.com, we introduce a platform to do this mapping at scale and identify mechanisms by which differentiation state dictates pyrimidine synthesis. 🧵👇 🔗 www.nature.com/articles/s42... 3135
Reposted by Yi XiaoChildren's Research Institute at UT Southwestern @cri-utsw.bsky.social · 19/09/2025We have the best postdocs! We appreciate you being a critical part of our CRI team to help discover the treatments of tomorrow. #npaw2025 #npaw #relentlessdiscovery 🧪 032
Yi Xiao @yixiao.bsky.social · 19/09/2025Excited to share another piece of my postdoc work, together with colleagues, we revealed an unappreciated signaling metabolite that stimulates neuronal activity in the glioma microenvironment and promotes glioma growth! 010
Yi Xiao @yixiao.bsky.social · 14/08/2025My postdoc preprint is online now! We revealed GSX2 as a target of mutant IDH in glioma. Check full text below. 010
Reposted by Yi XiaoChristian Frezza @frezzalab.bsky.social · 31/07/2025Silencing mitochondrial gene expression in living cells | Science www.science.org/doi/10.1126/...science.orgSilencing mitochondrial gene expression in living cellsMitochondria fulfill central functions in metabolism and energy supply. They express their own genome, which encodes key subunits of the oxidative phosphorylation system. However, the central mechanis... 13111
Reposted by Yi XiaoDeBerardinis Lab at UT Southwestern Medical Center @rjdlab.bsky.social · 05/12/2024Join us in Austin, TXm Feb 9-10 2025, for an Abcam-sponsored symposium on Cancer and Metabolism. -RJD events.abcam.com/event/cancer...events.abcam.comHome - Cancer and Metabolism 14513
