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Thomas P. Mathews, PhD

@mathews-tom.bsky.social
73 followers 102 following 6 posts

Assistant Professor studying #metabolism and #lipidmetabolism; leading #massspectrometery at CRI at UTSW. #metabolomics #lipidomics Views are my own.

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Thomas P. Mathews, PhD @mathews-tom.bsky.social · 02/09/2026
You are what you eat! Omega-6 and omega-3 fatty acids are essential fatty acids, meaning we only get them from the foods we eat and our bodies need them to thrive. These fats are essential for maintaining the fluidity of cellular membranes, but they’re also powerful signaling molecules in the cell.
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Thomas P. Mathews, PhD @mathews-tom.bsky.social · 03/03/2026
Great paper from Shana Kelley’s group about how the elongation of fatty acids by ELOVL6 maintains membrane anchor points that activate pathogenic KRAS variants. An unexpected way that fatty acid metabolism regulates a yet “unbridgeable” oncogenic variant. Very cool. www.nature.com/articles/s41...
nature.com
ELOVL6 activity attenuation induces mutant KRAS degradation - Nature Chemical Biology
Inhibition of ELOVL6, a fatty acid elongation enzyme, selectively degrades mutant KRAS, disrupts its membrane localization and suppresses tumor growth, revealing a novel vulnerability in KRAS-driven c...
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