In a recent Nature article, Tou et al. introduce INSTALL, a strategy that couples immune-evasive circular single-stranded DNA (cssDNA) technology with recombinase-based genome editing to overcome innate immune barriers and enable the integration of large DNA cargos.

In a recent Nature article, Tou et al.1 introduce INSTALL, a strategy that couples immune-evasive circular single-stranded DNA (cssDNA) technology wit…

INSTALL overcomes fundamental challenges for DNA delivery and integration methods by synergizing immune-stealth nucleic acids with recombinases to enable kilobase-scale integration strategies without ...

Nature Reviews Genetics, Published online: 13 May 2026; doi:10.1038/s41576-026-00971-1In this Tools of the Trade article, Connor Tou presents INSTALL, a recombinase-driven, kilobase-scale DNA integration method that employs partially duplexed circular single-stranded DNA to evade the cellular immune system.

In this Tools of the Trade article, Connor Tou presents INSTALL, a recombinase-driven, kilobase-scale DNA integration method that employs partially duplexed circular single-stranded DNA to evade the c...

Nature Biotechnology - Immune-stealth DNA for large cargo integration

INSTALL overcomes fundamental challenges for DNA delivery and integration methods by synergizing immune-stealth nucleic acids with recombinases to enable kilobase-scale integration strategies without ...

INSTALL overcomes fundamental challenges for DNA delivery and integration methods by synergizing immune-stealth nucleic acids with recombinases to enable kilobase-scale integration strategies without viral vectors.

INSTALL overcomes fundamental challenges for DNA delivery and integration methods by synergizing immune-stealth nucleic acids with recombinases to enable kilobase-scale integration strategies without ...

Former Intellia scientist John Finn reflects on gene editing's evolution and the closure of Tome Biosciences, highlighting the industry's focus on tools over medicines.

Defense-associated reverse transcriptases (DRTs) employ diverse and distinctive mechanisms of cDNA synthesis to protect bacteria against viral infection. However, much of DRT family diversity remains ...

This year, as in past years, we've found inspiring stories and innovative research. All are blazing new trails as they attempt to answer some of the

Click editing uses DNA polymerases, HUH endonucleases and oligonucleotide templates for genome modification.

A study of retrotransposon activity repurposes a retroelement called R2Tocc to create a programmable system called STITCHR that enables diverse genome edits including efficient, scarless large pa...

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