Buchholz Lab @buchholzlab.bsky.social · 10/09/2026As part of ONCOnnect Dresden’s contribution to the evaluation of the EKFS Medical Scientist Kollegs in Frankfurt/Main on 7 Sep 2026, Pascal Wang from our lab gave a presentation on ‘Restoring cancer genomes: A base editing platform for precision oncology’. #CGT #medicine #oncology #science 000
Buchholz Lab @buchholzlab.bsky.social · 25/08/2026On August 21, Frank Buchholz joined the Dresden Summer Reception and brought the topic of spin-offs to the stage - sharing insights into the dynamic world of startups that bridge the gap between research and industry. Thank you to everyone who contributed to this inspiring evening! 👏 020
Buchholz Lab @buchholzlab.bsky.social · 19/08/2026Thrilled to have been part of this year’s CRISPR Frontiers meeting at Cold Spring Harbor Laboratory - an inspiring few days of exciting science and great discussions! In memory of Prof. J. Michael Bishop. #CSHL2026 #GenomeEngineering #GeneEditing #MichaelBishopLegacy #InspiringScience 000
Buchholz Lab @buchholzlab.bsky.social · 30/06/2026Read Frank Buchholz's latest Nature Biotechnology article! A must-read for researchers in functional genomics. lnkd.in/d98vhQwNlnkd.inLinkedInThis link will take you to a page that’s not on LinkedIn 121
Buchholz Lab @buchholzlab.bsky.social · 26/05/2026Read the research highlight from Frank Buchholz in Molecular Cell on INSTALL - a recombinase-driven approach using engineered single-stranded donors that bypass innate immunity. www.sciencedirect.com/science/arti... #Science #Biotech #GeneTherapy #Innovationsciencedirect.comINSTALLing recombinase-driven genome writing: Engineered single-stranded donors bypass innate immunity to enable large DNA integrationIn a recent Nature article, Tou et al.1 introduce INSTALL, a strategy that couples immune-evasive circular single-stranded DNA (cssDNA) technology wit… 031
Buchholz Lab @buchholzlab.bsky.social · 22/05/2026An inspiring week at ASGCT2026 in Boston! Haidy Saleh Hassan from our team resented her work on multiplex (epi)gene editing of T cell inhibitory pathways to enhance persistence and function of adoptive T cell therapy in solid tumors, addressing a key challenge in patient relapse. #GenomeEditing 010
Buchholz Lab @buchholzlab.bsky.social · 02/04/2026Seamless Therapeutics is recognized as a top European biotech startup for 2026. Exciting to see our science making an impact! #GeneEditing #Biotech #Innovation #SeamlessTherapeutics #ResearchImpact european-biotechnology.com/background/1...european-biotechnology.com10 European Startups to watch in 2026 - European Biotechnology MagazineTen young European biotechs are heading into 2026 with the kind of momentum that can quickly turn promising science into defining data: first clinical entries, platform-to-pipeline transitions, and fu... 010
Buchholz Lab @buchholzlab.bsky.social · 27/03/2026Dont' miss "you ask WE EXPLAIN" with Frank Buchholz tomorrow at 7 PM at MPI-CBG! 000
Buchholz Lab @buchholzlab.bsky.social · 13/03/2026Looking forward to seeing you at Dennis’s talk on Monday! 001
Reposted by Buchholz LabMax Planck Institute of Molecular Cell Biology and Genetics @mpi-cbg.de · 03/03/2026The public event "CRISPR Gene scissors in Dresden" is taking place March 26 to 29. The "CRISPR-Roadshow" is teaming up with partners @mpi-cbg.de, @tudresden.bsky.social, and @crtd-tud.bsky.social for a wide range of activities on the CRISPR/Cas method. www.crispr-whisper.de/2025/10/01/d...crispr-whisper.deDie Genschere in Dresden, 26.3.2026 bis 29.3.2026 - CRISPR-WhisperDie „CRISPR-Roadshow“ ist ein Projekt des Forschungskonsortiums SPP2141, mit dem Wissenschaft für jedermann verständlich und erlebbar wird. Der SPP2141 ist eine Gruppe von 20 Forschungslaboren, die vo... 096
Buchholz Lab @buchholzlab.bsky.social · 03/03/2026Join us for an exciting seminar by Dennis Kappei (CSI Singapore & NUS) on "Hyperactivation of the ALT Pathway: Persistent Telomeric Bridge Formation" – exploring how ALT hyperactivation could pave the way for new cancer therapies! 📅 16 March, 5 PM 📍 UKD H66, 3rd floor #CancerResearch #Genomics #NUS 000
Buchholz Lab @buchholzlab.bsky.social · 24/02/2026Meet Dr. Shady Sayed, a pioneering translational scientist in the national Translational Tandem Program for Gene- and Cell-based Therapies! Read Shady’s inspiring interview and discover how CRISPR-based technologies are driving innovation in medicine! www.nationale-strategie-gct.de/en/funding/p...nationale-strategie-gct.deFellow-Interview SayedDie Nationale Strategie GCT soll durch gezielte Förderung und Vernetzung den Transfer von gen- und zellbasierten Therapien in die Praxis beschleunigen 011
Reposted by Buchholz LabBuchholz Lab @buchholzlab.bsky.social · 10/02/2026Ricardo Ruijpers from Helmholtz Institute & TU Munich will be joining us to discuss: "Harnessing HERV Envelopes for targeted RNA delivery". When? Monday, 23 February 2026, at 10:00 AM Where? BIOZ, 5th floor, Rooms 1+2 Hosted by: Prof. Dr. Frank Buchholz #Innovation #RNAResearch #ScienceSeminar 011
Reposted by Buchholz LabCTGCT (Centre for the Technologies of Gene and Cell Therapy) @ctgct.bsky.social · 12/02/2026Can we "erase" cancer by fixing a single DNA typo? Dr. Sayed, from @tudresden.bsky.social, is pioneering the use of CRISPR base editors to rewrite mutations in the P53 gene, the "guardian of the genome." Read how this technology is the future of personalized medicine: ctgct.si/en/objave/mo...ctgct.siMolecular Surgery: How Base Editors are Rewriting the Future of Cancer Therapy - CTGCTImagine being able to open the "instruction manual" of a human cell and fix a single typo that causes a life-threatening disease. This is no longer science fiction; it is the reality of base editors, ... 032
Buchholz Lab @buchholzlab.bsky.social · 10/02/2026Ricardo Ruijpers from Helmholtz Institute & TU Munich will be joining us to discuss: "Harnessing HERV Envelopes for targeted RNA delivery". When? Monday, 23 February 2026, at 10:00 AM Where? BIOZ, 5th floor, Rooms 1+2 Hosted by: Prof. Dr. Frank Buchholz #Innovation #RNAResearch #ScienceSeminar 011
Buchholz Lab @buchholzlab.bsky.social · 02/12/2025🎉 We’re thrilled to announce that we have been granted a European patent for our groundbreaking work on "Methods and Means for Genetic Alteration of Genomes Utilizing Designer DNA Recombining Enzymes"! A huge thank you to everyone involved in this achievement! #GenomeEditing #Innovation #TUDresden 000
Buchholz Lab @buchholzlab.bsky.social · 27/11/2025Revolutionizing Cancer Research! Dr. Haidy Saleh Hassan wins the 2025 Dissertation Award from Kulturstiftung Dresden of Commerzbank for Innovative Cancer Research for her groundbreaking work on glioblastoma treatment using adaptable immune cells! 🎉👏 #CancerResearch #Innovation #DresdenAward 000
Buchholz Lab @buchholzlab.bsky.social · 14/11/2025Dr. Ludwig Mayerlein (Synovo GmbH) will discuss high-yield platforms for Marburg virus glycoprotein production and purification, addressing both innovation and scale-up challenges. Nov 17, 11:00 AM | CRTD SR3 All are welcome! #Science #Vaccines #MarburgVirus #Dresden #CMCB 010
Buchholz Lab @buchholzlab.bsky.social · 12/11/2025Our #BaseEditing paper is DG-GT’s “Paper of the Quarter”! 🎉 We used precise gene editing to correct cancer mutations in TP53 – and watched as corrected cells nearly vanished. A step toward mRNA therapies for cancer! 💡 Full paper: rdcu.be/exqtH #CancerResearch #GeneEditing #Science #DG_GTrdcu.beA base editing platform for the correction of cancer driver mutations unmasks conserved p53 transcription programs 000
Buchholz Lab @buchholzlab.bsky.social · 06/11/2025Our lab shone at EMBO Workshop CRISPR-Cas: From Biology to Therapeutic Applications in Sorrento! Haidy presented her award-winning poster on modulating anti-tumor efficacy & T cell exhaustion! 🏆Frank shared insights on developing a BE platform for cancer research. #CRISPR #EMBO #Science #GeneEditing 010
Buchholz Lab @buchholzlab.bsky.social · 04/11/2025We’re live! The Buchholz Lab’s 'CanCorrect' project has begun, funded by a BMFTR VIP+ grant. This grant will help us take our research to the next level, with the goal of advancing personalized cancer therapy. #CancerResearch #CRISPR #Science #Innovation #BMFTR 000
Buchholz Lab @buchholzlab.bsky.social · 30/10/2025Shaping the future of healthcare! Frank Buchholz was part of the German Federal Ministry of Health’s event in Berlin to discuss ATMP Innovation Centers. Exciting discussions on how advanced therapies can transform patient care. #Innovation #Healthcare #ATMP #FutureOfMedicine #CarstenMüller-Tidow 000
Buchholz Lab @buchholzlab.bsky.social · 28/08/2025Rewriting the Code of Life: A “The Scientist Speaks” podcast with Frank Buchholz on programmable recombinases Tune in to hear Frank’s insights and discover how this innovation is shaping the future of medicine and beyond!podcasts.apple.comThe Future of Gene Editing with Programmable RecombinasesPodcast-Folge · The Scientist Speaks · 27.08.2025 · 16 Min. 000
Buchholz Lab @buchholzlab.bsky.social · 31/07/2025🎉 Buchholz Lab's new study uses base editing to target TP53 mutations in cancer! We fixed mutations in various cell lines, revealing key insights for precision therapies. Big congrats to our team! 👏 Read more here 🔗 kurzlinks.de/p9r6link.springer.comA base editing platform for the correction of cancer driver mutations unmasks conserved p53 transcription programs 000
Buchholz Lab @buchholzlab.bsky.social · 17/06/2025Frank Buchholz has been awarded the ERC Advanced Grant for groundbreaking research on genome editing a second time! 🎉 His project titled “DNA-binding domain Conditioned Precision Genome Editing” has been selected for funding! 020
