Background: Posttraumatic stress disorder (PTSD) occurs following potentially traumatic experiences, but not everyone who experiences trauma develops PTSD. Genetic factors play an important role in...

A major new study carried out in collaboration with an international partnership of researchers, has, for the first time, compared the genetics of people with binge eating versus those without any eat...

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Genome-wide association studies of individuals with binge-eating behavior, anorexia nervosa or neither identify distinct genetic associations with each phenotype. Although both eating disorder phenoty...

This research identified six areas in the genome that are associated with binge eating, and eight areas that are associated with anorexia nervosa, in people of European ancestry. Binge eating has both...

This course will develop your knowledge about genetic and environmental causes of developmental psychopathology across the lifespan.

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The ability to discriminate thousands of odors in our environment requires each olfactory neuron to express a single olfactory receptor from hundreds of available genes. The biochemical mechanism enfo...

Gene-environment interactions are critical for understanding the genetics of PTSD, although it remains unclear how they differ across traumas. Using data from the UK Biobank and GLAD-EDGI-COPING (N=14...

Unlocking mental health insights with UK Biobank data: Past use and future opportunities - Volume 55

This study used fine-mapping to analyze genetic regions associated with bipolar disorder, identifying specific risk genes and providing new insights into the biology of the condition that may guide fu...

Nature Human Behaviour - This study uncovered genetic associations with environmental sensitivity in psychiatric and neurodevelopmental traits in an international collaboration using data from more...

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Background This paper introduces the UK Biobank (UKB) second mental health questionnaire (MHQ2), describes its design, the respondents and some notable findings. UKB is a large cohort study with over ...

Eating disorders - including anorexia nervosa (AN), bulimia nervosa, and binge eating disorder - are clinically distinct but exhibit symptom overlap and diagnostic crossover. Genomic analyses have mos...

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Eugenics, that promoted planned breeding to ensure 'racial improvement', was central to the development of genetics and led to horrifying policies. However, eugenics is not dead and continues to influ...

Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

Using genome-wide meta-analyses of clinical measures of depression and biobank data, the authors investigate symptom-specific genetic associations between depression and subsequent risk for Alzheimer’...

Trans-ancestry GWAS of major depression identifies 697 genetic variants and 308 genes, implicating neural and molecular mechanisms and drug repurposing opportunities.

Background: This paper introduces the UK Biobank (UKB) second mental health questionnaire (MHQ2), describes its design, the respondents and some notable findings. UKB is a large cohort study with over...