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Cathryn Lewis

@cathrynlewis.bsky.social
1.2K followers 760 following 30 posts

Genetics - Statistics - Psychiatry. Depression pharmacogenetics. SGDP Centre, King’s College London. Psychiatric Genomics Consortium.

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Reposted by Cathryn Lewis
Inspire the Mind ✍️🧠 @inspirethemind.bsky.social · 29/10/2025
In today’s article, @kingsioppn.bsky.social Professor Cathryn Lewis @cathrynlewis.bsky.social discusses current evidence on the efficacy of #antidepressants and how research should move forward to support #precisionmedicine approaches in #mentalhealth. www.inspirethemind.org/post/underst...
inspirethemind.org
Understanding who benefits from antidepressants
Why is the use of antidepressants so controversial, and how could we prescribe them more effectively? This question is a priority in my research at King’s College London, where I work as professor of ...
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Cathryn Lewis @cathrynlewis.bsky.social · 23/09/2025
Autumns has arrived - the @kingsioppn.bsky.social campuses are buzzing with new students but still sunny and mild enough for an early morning coffee outside at Ortus.
Outdoor cafe table with laptop and coffee cup
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Cathryn Lewis @cathrynlewis.bsky.social · 15/09/2025
If your Monday morning is challenging, this post is a reminder of positive changes over the last 10 years. From cancer treatment to music access to dresses-with-pockets Hang in there amid the turmoil.
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Cathryn Lewis @cathrynlewis.bsky.social · 11/08/2025
🚨Come work with us!🚨 Open post for Clinical Psychology Lecturer, combining NHS clinical work with research and education at the SGDP Centre.
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Cathryn Lewis @cathrynlewis.bsky.social · 11/08/2025
Do you analyse #polygenic scores across ancestry groups? See Oliver Pain's extension to the GenoPred pipeline, with recommendations for good practice and efficient analysis. @oliverpain.bsky.social 🔗 Paper: lnkd.in/evJ9daBF 🔗 GenoPred pipeline: lnkd.in/eKwFr9kQ www.linkedin.com/posts/oliver...
linkedin.com
🚨 My new paper is out! | Oliver Pain, PhD posted on the topic | LinkedIn
🚨 My new paper is out! 🧬 Improving polygenic score (PGS) accuracy and equity across ancestrally diverse populations — with and without individual-level tuning data.  I benchmarked leading single-sou...
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Reposted by Cathryn Lewis
Sam Westwood @samwestwood.bsky.social · 11/06/2025
We're back, with a fresh new lineup of talks and workshops! Get your place while you still can to learn about how to make your research more robust and how to deal with scientific fraud! This event is free and open to all: tinyurl.com/3ewaduvm
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Reposted by Cathryn Lewis
Hanna Maria Kariis @hannamariakariis.bsky.social · 02/07/2025
🎉(1/4) Excited to share that our latest paper is now published! We investigated genetic factors linked to antidepressant side effects in 13,000 individuals from the @estbiobank.bsky.social , leveraging data from questionnaires and clinical notes using NLP. www.nature.com/articles/s41...
nature.com
Genetic influences on antidepressant side effects: a CYP2C19 gene variation and polygenic risk study in the Estonian Biobank - European Journal of Human Genetics
European Journal of Human Genetics - Genetic influences on antidepressant side effects: a CYP2C19 gene variation and polygenic risk study in the Estonian Biobank
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Cathryn Lewis @cathrynlewis.bsky.social · 27/06/2025
This morning's email had *four* paper review requests - again. Important to contribute to keeping peer review moving. We have two papers languishing at journals for 6-9 months, with real impact on #ECR careers. Suggestions for short-term fixes to help this broken system? #academia #publishing
Sunflowers in my garden - pretty, but no relevance to the message.
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Cathryn Lewis @cathrynlewis.bsky.social · 09/06/2025
At @edinburghup.bsky.social University for two day AMBER team meeting. @wellcometrust.bsky.social project to identify the causal mechanisms underlying #antidepressants using informatics, genomics & cellular approaches.
Presenter giving project updates
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Reposted by Cathryn Lewis
Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 05/06/2025
(1/2) Only one-third of people taking antidepressants for depression respond to the first drug they are prescribed and we know little about WHICH drug will work for each patient.
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Reposted by Cathryn Lewis
Magdalena Skipper @magdalenaskipper.bsky.social · 31/05/2025
Women make up only 16% of corresponding authors who submit to Nature, a new Springer Nature analysis revealed. This is not enough - there are 30-40% #womeninSTEM We want to change it, through targeted editorial policies & outreach. But change will take everyone! 🧪 www.nature.com/articles/d41...
nature.com
Gender equality in research publishing is a responsibility for everyone
A concerted effort is needed to support women in their choice of journal when submitting their manuscript.
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Reposted by Cathryn Lewis
NIHR Biomedical Research Centre: Maudsley @nihrmaudsleybrc.bsky.social · 29/05/2025
"This work is a first step in using health records to define and predict SSRI drug responses." - Professor Cathryn Lewis @cathrynlewis.bsky.social is Deputy Lead of our Trials, Genomics and Prediction theme, and the research was supported by @nihr.bsky.social and @wellcometrust.bsky.social 👇
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Cathryn Lewis @cathrynlewis.bsky.social · 28/05/2025
Our new paper assessing switching between antidepressants as a measure of non-response is now out in BPGOS. Genetic studies show prediction from polygenic scores of remission from clinical studies. Paper: www.sciencedirect.com/science/arti... @kingsioppn.bsky.social Webstory ⬇️
sciencedirect.com
Antidepressant Switching as a Proxy Phenotype for Drug Nonresponse: Investigating Clinical, Demographic, and Genetic Characteristics
Selective serotonin reuptake inhibitors (SSRIs) are a first-line pharmacological therapy in major depressive disorder (MDD), but treatment response ra…
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Cathryn Lewis @cathrynlewis.bsky.social · 27/05/2025
Congratulations to Lachlan Gilchrist for his successful #PhD viva on Friday. He even admitted to enjoying the discussion! Thanks to examiners @daniellenewby.bsky.social and Golam Khandaker & my @drivehealth.bsky.social co-supervisor @ppetra.bsky.social. @kingsioppn.bsky.social
Picture of five people in an academic office - stuent, two supervisors and two examiners.  Broad smiles!
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Cathryn Lewis @cathrynlewis.bsky.social · 22/05/2025
The SGDP Centre Atrium bookshare captures so much of our work culture. From The Very Hungry Caterpillar to Neuropsychiatry to Jane Austen & Sarah J Maas. Books in English, Chinese, French. Suggested donations supporting local charity. All welcome to donate & borrow, @kingsioppn.bsky.social
Picture of a book case, overloaded with books, in an open space at the SGDP Centre at King's College London
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Cathryn Lewis @cathrynlewis.bsky.social · 14/05/2025
#IoPPNFestival Fran Denk @denklab.bsky.social, winner of @kingsioppn.bsky.social Dean’s award for Research Integrity highlighting the importance of statistical understanding and application to support good research practices - honest, rigorous, open, respectful. #statistics rocks!
Lecture theatre and slide
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Reposted by Cathryn Lewis
Institute of Psychiatry, Psychology & Neuroscience @kingsioppn.bsky.social · 14/05/2025
The #IoPPNResearchFest is here! Join us for rapid-fire talks by IoPPN staff on the latest research in psychiatry, psychology + neuroscience, from the power of belief, neurotrauma and more. Follow us and @thementalelf.bsky.social for highlights and key messages. #AcademiaSky
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Cathryn Lewis @cathrynlewis.bsky.social · 29/04/2025
#BNA2025 Great addition to a conference- a Reading Room - with a view. Thanks to The Queen’s Reading Room for funding and interesting sessions on reading + neuroscience
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Cathryn Lewis @cathrynlewis.bsky.social · 28/04/2025
#BNA2025 Ekta Patel from the Psychiatry Consortium, part of @md-catapult.bsky.social launches our Academia - Industry symposium. Strengthening collaborations through grand challenges, target validation and engagement
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Cathryn Lewis @cathrynlewis.bsky.social · 08/04/2025
Postdoc closing soon - two more days to apply for our statistical genetics role in antidepressant response at @kingsioppn.bsky.social
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Reposted by Cathryn Lewis
POP-GEM Lab @popgemlab.bsky.social · 04/04/2025
(1/1) 🧠🌎 Just published in Nature Genetics: “Psychiatric genetics in the diverse landscape of Latin American populations” A comprehensive review of progress, challenges, and future directions. 🔗 www.nature.com/articles/s41... #PsychiatricGenetics #GlobalGenomics
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Cathryn Lewis @cathrynlewis.bsky.social · 27/03/2025
📬New job 📬 Postdoc role on the AMBER project, to undertake genetic analyses of antidepressant response. Join us! Important science, rich data, nice people. Please repost. @kingsioppn.bsky.social #depression #statistics #genetics #pharmacogenetics #antidepressants my.corehr.com/pls/coreport...
Picture of Cathryn Lewis' research group at the SGDP Centre, waving and smiling.
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Reposted by Cathryn Lewis
International Society of Psychiatric Genetics @ispg.bsky.social · 23/03/2025
Join us for the ISPG Members' Meetup on March 26th! Dr. Oliver Pain will present his groundbreaking research on polygenic scores and the innovative GenoPred pipeline. Don't miss out: us06web.zoom.us/meeting/regi... #ISPG #Genetics #PolygenicScores #Bioinformatics
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Cathryn Lewis @cathrynlewis.bsky.social · 17/03/2025
Paper published: first output from our Wellcome Trust Mental Health Award, AMBER, on how UK Biobank participants report on whether antidepressants helped their depression. tl;dr 75% said SSRI antidepressants helped them feel better ➡️ Paper in Psychological Medicine bit.ly/4ifjcWC 🧵
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Reposted by Cathryn Lewis
Institute of Psychiatry, Psychology & Neuroscience @kingsioppn.bsky.social · 13/03/2025
Three quarters of people who have taken #antidepressants say they helped them "feel better" in new IoPPN research. Read more➡️ www.kcl.ac.uk/news/three-q... #SSRI @wellcometrust.bsky.social @edinburghuni.bsky.social @nihrmaudsleybrc.bsky.social @ukbiobank.bsky.social @kingscollegelondon.bsky.social
"While antidepressants don’t work for every user, this research provides reassuring evidence that many people report that this common type of medication is helping them manage what can be a severe illness." Dr Michelle Kamp, Postdoctoral Research Associate at King’s IoPPN
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Reposted by Cathryn Lewis
Alice Braun @alicebraun.bsky.social · 12/03/2025
The Ripke lab has worked on a new stable release of RICOPILI! Updates include compatibility with GRCh38 and imputation using Minimac4. A software tarball and YAML file are provided to help resolve dependency issues: github.com/Ripkelab/ric... Any feedback is highly welcome! @pgcgenetics.bsky.social
github.com
GitHub - Ripkelab/ricopili: Main ricopili repo for public releases
Main ricopili repo for public releases. Contribute to Ripkelab/ricopili development by creating an account on GitHub.
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Reposted by Cathryn Lewis
Institute of Psychiatry, Psychology & Neuroscience @kingsioppn.bsky.social · 24/02/2025
In 2016, TV reporter James Longman met with IoPPN researchers Profs @cathrynlewis.bsky.social & Roland Zahn on BBC Two to understand how #depression can run in families. His new memoir #TheInheritedMind documents his personal investigation into mental illness. www.theguardian.com/books/2025/f...
theguardian.com
The Inherited Mind by James Longman review – a moving memoir of mental illness in the family
The TV reporter’s struggles with depression and the suicide of his father, whose own father killed himself, prompt this incisive, highly personal investigation
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Reposted by Cathryn Lewis
Institute of Psychiatry, Psychology & Neuroscience @kingsioppn.bsky.social · 15/01/2025
NEW research by IoPPN (@cathrynlewis.bsky.social) and @edinburghuni.bsky.social (Andrew McIntosh) researchers have identified new genetic risk factors for #depression across all global populations for the 1st time, in study in Cell Read more: www.kcl.ac.uk/news/global-...
kcl.ac.uk
Global study pinpoints genes for depression across ethnicities
Researchers at King's College London and University of Edinburgh have identified new genetic risk factors for depression across all major global populations for the first time, allowing scientists to predict risk of depression regardless of ethnicity.
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Cathryn Lewis @cathrynlewis.bsky.social · 09/01/2025
To start 2025 on a cheerful note, the SGDP Centre, @kingsioppn.bsky.social are 'dopamine dressing'. Today - 🟥red, 16th Jan -🟦blue, 23rd Jan - 🟩green, 30th Jan - 🏳️‍🌈any bright colour. Even socks count!
Picture of scientists dressed in red
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Reposted by Cathryn Lewis
Institute of Psychiatry, Psychology & Neuroscience @kingsioppn.bsky.social · 19/12/2024
New research (Julian Mutz, Raquel Iniesta, @cathrynlewis.bsky.social) has evaluated AI-based metabolomic 'ageing clocks', which predict health and lifespan using data from blood. It was published in Science Advances, with support of the @nihrmaudsleybrc.bsky.social www.kcl.ac.uk/news/researc...
kcl.ac.uk
Researchers compare artificial intelligence 'ageing clocks' to predict health and lifespan
Researchers at the Institute of Psychiatry, Psychology & Neuroscience have conducted a comprehensive study to evaluate artificial intelligence based ageing clocks, which predict health and lifespan us...
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