Reposted by Charlotte Odendall
#ChangeTheDogma! #TLRpower! @jkagan1.bsky.social @danielhfisch.bsky.social &co show @nature.com that TRAM, so far believed to control endosomal TLR4 signaling & interferon #IFN production, is essential to release the #myddosome from #TIRAP & the plasma membrane allowing full NFkB signaling!
nature.com
TRAM promotes Toll-like-receptor-free myddosome signal transduction - Nature
TRAM is a regulator of myddosome assembly through dissociating MyD88 from the TLR–TIRAP complex to enable myddosome maturation and durable downstream signal transduction.