How Two Large Outcome Trials Based on Surrogate Metrics Failed

Solar lease-to-own could unlock Ireland's energy future — Uruguay, the Netherlands and Germany have all made this work with straightforward rules, writes Mary Teehan

Coding agents like Claude Code, Cursor, and Codex have taken the software engineering field by storm. What makes them tick?

De novo peptide sequencing from tandem mass spectrometry is pivotal in proteomics, enabling identification of novel peptides without reference databases. While recent Transformer-based encoder-decoder...

Immigration sometimes needs brakes, but the proposal would be like driving into a wall

Causal inference seeks to estimate the effect of an intervention on an outcome using observed data, typically via Rubin's potential-outcome framework or Pearl's do-calculus. Following section 9 of Ric...

Exposure–response analyses are central to dose selection in drug development. The estimand framework, formalized in ICH E9(R1) regulatory guidance, provides a structured approach to define scientific...

In epidemiology, some have argued that multiple comparison corrections are not necessary as there is rarely interest in the universal null hypothesis. From a parameter estimation perspective, epidemio...

Facilitates estimating, visualizing, and testing average dose-response functions (ADRFs) for characterizing the causal effect of a continuous (i.e., non-discrete) treatment or exposure. Includes suppo...

Uruguay built a power grid that runs 99% on renewables—at half the cost of fossil fuels. Here’s how its bold energy overhaul became a global model.

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IL-17 signalling restricts C. albicans pathogenicity in the colonized oral cavity. Lack of IL-17 is associated with overt filamentation due to impaired zinc nutritional immunity and over time leads to...

Even at an accelerated recent pace, seizing Ukraine’s eastern regions would take more than two years

It is a sad mix of naked opportunism and strategic myopia

The best drug to fight malaria is facing increased resistance from the parasites it fights. Now there's an alternative in the pipeline and it looks promising.