Neuropeptides are chemically diverse signaling molecules that regulate physiology and behavior, yet many species lack neuropeptidomic characterization due to sparse genomic annotation. Here, we integr...

The task force determines which preventive services insurers must cover at no cost to patients.

The Latin Times reports: In celebration of Pride Week, more than five thousand LGBTQ+ activists converged on Mexico City’s Zócalo to form the world’s largest human LGBT flag. Under a shower of rain an...

Transgender and gender nonconforming (TGnC) people are a primary target of the Trump administration. Multiple executive orders seek to erase TGnC protections; mandate denial of gender identity; and ba...

Neuropeptides are critical endogenous signaling molecules involved in a wide range of biological processes, including neurotransmission, hormonal regulation, immune responses, and stress management. D...

After just 100 days, agency scientists say U.S. health institutes are demoralized and have lost essential staff and funding

Neuropeptides are vital signaling molecules involved in neural communication, hormonal regulation, and stress response across diverse taxa. Despite their critical roles, neuropeptide research remains ...

Petra Boynton looks at what advice UK universities should give US-bound researchers and students

Scientists, with expertise in fields that include mental health, cancer and infectious disease, typically serve five-year terms and were not given a reason for their dismissal.

Mass spectrometry imaging (MSI) has gained popularity in clinical analyses due to its high sensitivity, specificity, and throughput. However, global profiling experiments are often still restricted to LC-MS/MS analyses that lack spatial localization due to low-throughput methods for on-tissue peptide identification and confirmation. Additionally, the integration of parallel LC-MS/MS peptide confirmation, as well as histological stains for accurate mapping of identifications, presents a large bottleneck for data analysis, limiting throughput for untargeted profiling experiments. Here, we present a novel platform, termed MSIght, which automates the integration of these multiple modalities into an accessible and modular platform. Histological stains of tissue sections are coregistered to their respective MSI data sets to improve spatial localization and resolution of identified peptides. MS/MS peptide identifications via untargeted LC-MS/MS are used to confirm putative MSI identifications, thus generating MS images with greater confidence in a high-throughput, global manner. This platform has the potential to enable large-scale clinical cohorts to utilize MSI in the future for global proteomic profiling that uncovers novel biomarkers in a spatially resolved manner, thus widely expanding the utility of MSI in clinical discovery.

Nearly 40 students report canceled visas over minor infractions as Trump intensifies crackdown on universities

A number of grant proposals have disappeared from scientists’ review pipelines, with little explanation. Applicants are bewildered and frustrated.