Tissue expansion mass spectrometry imaging enables the mapping of lipids, metabolites, proteins, peptides and N-glycans at high spatial resolution.

Abstract. Benign prostatic hyperplasia (BPH) is a disease affecting the majority of aging men; 90% of men develop histological BPH by the time they reach t

Neuropeptides are chemically diverse signaling molecules that regulate physiology and behavior, yet many species lack neuropeptidomic characterization due to sparse genomic annotation. Here, we integr...

Human pancreatic islets are highly heterogeneous; thus, understanding their biological organization is crucial for elucidating metabolic function and diabetes pathogenesis. High-resolution mass spectr...

Click to launch & play an online audio visual presentation by Prof. Brandon T. Ruotolo on Introduction to mass spectrometry 1, part of a collection of multimedia lectures.

Protein glycosylation and phosphorylation are critical post-translational modifications (PTMs) that regulate diverse physiological and pathological pr…

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Characterizing the proteome of an organism can provide critical insights into the proteins that regulate key biological processes such as development, physiology, and environmental interactions. While...

Data-independent acquisition (DIA) has emerged as a powerful approach in quantitative proteomics, offering more comprehensive and reproducible proteome coverage than the conventional data-dependent ac...

Single-cell mass spectrometry imaging (MSI) has emerged as a transformative technology for dissecting complex biological systems with high spatial pre…

Osteoarthritis (OA) is a complex and increasingly prevalent condition, affecting an estimated 600 million people worldwide and significantly reducing quality of life. Understanding OA as both an infla...

Professor Lingjun Li reflects on her lab’s interdisciplinary research, the importance of spatial molecular imaging, and how tools like AI and mass spectrometry are shaping the future of biomedical sci...

Molecular Psychiatry - Increased expression of ATase1/NAT8B or ATase2/NAT8 in the mouse results in an autistic-like phenotype with altered dendritic branching and spine formation