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Nature - Drug trials have typically excluded pregnant people for safety reasons. But that’s now starting to change.

Lung cancer in never smokers (LCINS) is a growing global health challenge. Unlike smoking-related lung cancer, LCINS is characterized by distinct epidemiological patterns and unique molecular pathogenesis and, consequently, requires different clinical management approaches. Unfortunately, for patients with lung cancer who have never smoked, symptoms are nonspecific and often dismissed due to these patients not fitting a high-risk profile (e.g., smoker), underscoring the need for improved detection and interception. Emerging risk factors, including germline variants, clonal hematopoiesis, and environmental exposures, offer new avenues for risk stratification and preventive strategies. While low-dose computed tomography screening shows promise in high-risk subgroups, challenges remain in optimizing cost-effectiveness. Novel prevention approaches, from interleukin (IL)-1β inhibition to cancer vaccines, are under investigation. This opinion article discusses why LCINS demands unique clinical and research paradigms to address its biological complexity.

In the United States and elsewhere, there’s been a major shift in patients treated for lung cancer.

In 2020, lung cancer in people who had never smoked was the fifth most common cause of cancer death worldwide

The changes announced by a major UK science funder are putting scientists — and the future of research — in a difficult position.

Extrachromosomal DNA (ecDNA) drives oncogene amplification, tumour evolution and therapy resistance across cancers. This Review summarizes advances in ecDNA biology, highlights emerging therapeutic vu...

In the United States and elsewhere, there’s been a major shift in patients treated for lung cancer.

Lung cancer in never smokers (LCINS) is a growing global health challenge. Unlike smoking-related lung cancer, LCINS is characterized by distinct epidemiological patterns and unique molecular pathogen...

Twelve early-career researchers who started their independent research groups in 2025 reflect on their experiences from this first year of the journey, describe the opportunities they have had and the...

In this podcast I speak to Simon about his important research into the causes of bladder cancer, as well as his life and career.Story from Kidney Research UK about Simon's important breakthrough: http...

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

Alexander Raven, an early career researcher from the School of Cancer Sciences, has been awarded one of UK Research and Innovation’s (UKRI) flagship Future Leaders Fellowships.

The upper airway epithelium in humans is maintained in homeostasis by a resident population of basal stem cells. In the presence of tobacco smoke these gain mutations that significantly increase their...

Research into the causes of lung cancer and Alzheimer’s disease are among 77 projects to be funded by UKRI’s Future Leaders Fellowships.

Background Tobacco smoke is a known mutagen. However, its physiological effects on the lung may also influence the somatic selective pressures acting on mutations, further shaping cancer evolution. Th...

The Pre-Cancer Immunology Lab (James Reading Lab) is mapping pre-invasive T cell dynamics during carcinogenesis to detect and intercept cancer development.

Pioneering research in lung cancer to improve diagnosis, treatment and prevention

Analyses of in vivo models, cell lines and patient-derived samples show that apolipoprotein B mRNA-editing catalytic subunit 3B (APOBEC3B) not only restrains lung tumor initiation but also that its up...

Using a natural experiment that avoids common bias concerns, this study finds that the live-attenuated shingles vaccine reduced the probability of a new dementia diagnosis within a follow-up period of...

Genomic instability driven by stress-response-dependent mutagenesis is a key factor in cancer progression. Tyrosine kinase inhibitor therapy, a common…

Genomic instability driven by stress-response-dependent mutagenesis is a key factor in cancer progression. Tyrosine kinase inhibitor therapy, a common…

Double-stranded RNAs (dsRNAs) produced during viral infections are recognized by the innate immune sensor protein kinase R (PKR), triggering a host translation shutoff that inhibits viral replication ...